SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2igp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2DYS_W_CHDW101_0 (CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART CYTOCHROME C OXIDASE SUBUNIT 1)	2igp	RETINOBLASTOMA-ASSOC IATED PROTEIN HEC (Homo sapiens)	4 / 6	LEU A 185 ARG A 97 THR A 104 LEU A 103	None BME A 269 (-3.2A) None None	0.96A	2dysN-2igpA: undetectable 2dysW-2igpA: undetectable	2dysN-2igpA: 12.50 2dysW-2igpA: 15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZXW_J_CHDJ60_0 (CYTOCHROME C OXIDASE POLYPEPTIDE 7A1 CYTOCHROME C OXIDASE SUBUNIT 1)	2igp	RETINOBLASTOMA-ASSOC IATED PROTEIN HEC (Homo sapiens)	4 / 6	LEU A 185 ARG A 97 THR A 104 LEU A 103	None BME A 269 (-3.2A) None None	0.99A	2zxwA-2igpA: undetectable 2zxwJ-2igpA: undetectable	2zxwA-2igpA: 12.50 2zxwJ-2igpA: 15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X1F_J_CHDJ101_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	2igp	RETINOBLASTOMA-ASSOC IATED PROTEIN HEC (Homo sapiens)	4 / 6	LEU A 185 ARG A 97 THR A 104 LEU A 103	None BME A 269 (-3.2A) None None	1.09A	5x1fA-2igpA: undetectable 5x1fJ-2igpA: undetectable	5x1fA-2igpA: 12.50 5x1fJ-2igpA: 15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ZCP_W_CHDW101_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	2igp	RETINOBLASTOMA-ASSOC IATED PROTEIN HEC (Homo sapiens)	4 / 8	LEU A 185 ARG A 97 THR A 104 LEU A 103	None BME A 269 (-3.2A) None None	0.91A	5zcpN-2igpA: undetectable 5zcpW-2igpA: undetectable	5zcpN-2igpA: 12.50 5zcpW-2igpA: 15.38

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2DYS_W_CHDW101_0","CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART;CYTOCHROME C OXIDASE SUBUNIT 1","2igp","RETINOBLASTOMA-ASSOCIATED PROTEIN HEC","Homo sapiens",4,"LEU A 185;ARG A  97;THR A 104;LEU A 103","None;BME A 269 (-3.2A);None;None","0.96A","2dysN-2igpA:undetectable;2dysW-2igpA:undetectable","2dysN-2igpA:12.50;2dysW-2igpA:15.38"],["2ZXW_J_CHDJ60_0","CYTOCHROME C OXIDASE POLYPEPTIDE 7A1;CYTOCHROME C OXIDASE SUBUNIT 1","2igp","RETINOBLASTOMA-ASSOCIATED PROTEIN HEC","Homo sapiens",4,"LEU A 185;ARG A  97;THR A 104;LEU A 103","None;BME A 269 (-3.2A);None;None","0.99A","2zxwA-2igpA:undetectable;2zxwJ-2igpA:undetectable","2zxwA-2igpA:12.50;2zxwJ-2igpA:15.38"],["5X1F_J_CHDJ101_0","CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","2igp","RETINOBLASTOMA-ASSOCIATED PROTEIN HEC","Homo sapiens",4,"LEU A 185;ARG A  97;THR A 104;LEU A 103","None;BME A 269 (-3.2A);None;None","1.09A","5x1fA-2igpA:undetectable;5x1fJ-2igpA:undetectable","5x1fA-2igpA:12.50;5x1fJ-2igpA:15.38"],["5ZCP_W_CHDW101_0","CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","2igp","RETINOBLASTOMA-ASSOCIATED PROTEIN HEC","Homo sapiens",4,"LEU A 185;ARG A  97;THR A 104;LEU A 103","None;BME A 269 (-3.2A);None;None","0.91A","5zcpN-2igpA:undetectable;5zcpW-2igpA:undetectable","5zcpN-2igpA:12.50;5zcpW-2igpA:15.38"]]