SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2igs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2igs HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 TYR A  63
ILE A  42
VAL A 205
ALA A  68
GLY A  11
 None
 1.18A 1kiaB-2igsA:
undetectable		 1kiaB-2igsA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2igs HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		4 / 8 PHE A 119
SER A 149
ALA A 210
LEU A 209
 None
 1.03A 2o01A-2igsA:
undetectable		 2o01A-2igsA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2igs HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 ILE A  37
ILE A   4
LEU A 116
 None
 0.41A 2prgA-2igsA:
undetectable		 2prgA-2igsA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 2igs HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 SER A 133
GLY A 145
SER A 141
 None
 0.68A 3loqA-2igsA:
undetectable		 3loqA-2igsA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2igs HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		4 / 6 TYR A   7
GLN A   8
ILE A  56
SER A  13
 None
None
None
SO4  A2006 ( 3.8A)
 1.08A 3pmzD-2igsA:
undetectable		 3pmzD-2igsA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		 2igs HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 209
PHE A 119
TYR A 211
ASP A 117
GLY A 112
 None
None
None
None
ACY  A2018 (-3.5A)
 1.39A 4j7xF-2igsA:
undetectable		 4j7xF-2igsA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 2igs HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		5 / 8 ALA A  39
ILE A  42
ALA A 213
PHE A 212
LEU A 208
 None
 0.91A 4v1fA-2igsA:
undetectable
4v1fB-2igsA:
undetectable		 4v1fA-2igsA:
17.05
4v1fB-2igsA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 2igs HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		4 / 6 PHE A 119
TYR A 150
TYR A 201
PHE A  50
 None
 1.34A 5lrbA-2igsA:
undetectable		 5lrbA-2igsA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 2igs HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		4 / 6 VAL A 205
TYR A 115
ILE A  42
GLU A  38
 None
 0.93A 5z3jA-2igsA:
undetectable		 5z3jA-2igsA:
21.86