SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2igt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)		 2igt SAM DEPENDENT
METHYLTRANSFERASE
(Agrobacterium
fabrum) 		3 / 3 ALA A  64
VAL A  60
TRP A  61
 None
 0.76A 1bdwA-2igtA:
undetectable
1bdwB-2igtA:
undetectable		 1bdwA-2igtA:
3.66
1bdwB-2igtA:
3.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 2igt SAM DEPENDENT
METHYLTRANSFERASE
(Agrobacterium
fabrum) 		4 / 8 GLY A 144
ASN A 138
GLY A 141
VAL A 249
 None
 0.83A 1dbbH-2igtA:
undetectable
1dbbL-2igtA:
undetectable		 1dbbH-2igtA:
22.84
1dbbL-2igtA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		 2igt SAM DEPENDENT
METHYLTRANSFERASE
(Agrobacterium
fabrum) 		4 / 6 ASP A 290
GLY A 291
THR A 293
PRO A 294
 None
 0.73A 1n4fA-2igtA:
undetectable		 1n4fA-2igtA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 2igt SAM DEPENDENT
METHYLTRANSFERASE
(Agrobacterium
fabrum) 		4 / 6 LEU A 176
GLU A 172
TRP A 169
THR A 105
 None
 1.47A 1qvuA-2igtA:
undetectable		 1qvuA-2igtA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 2igt SAM DEPENDENT
METHYLTRANSFERASE
(Agrobacterium
fabrum) 		4 / 4 THR A 251
GLY A 141
ASP A 161
ALA A 191
 None
None
SAM  A1001 (-2.9A)
SAM  A1001 (-3.6A)
 1.27A 1sg9A-2igtA:
13.2		 1sg9A-2igtA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		 2igt SAM DEPENDENT
METHYLTRANSFERASE
(Agrobacterium
fabrum) 		3 / 3 LEU A  16
LEU A 282
SER A 301
 ACY  A1010 (-4.9A)
None
None
 0.26A 1tlmA-2igtA:
undetectable		 1tlmA-2igtA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 2igt SAM DEPENDENT
METHYLTRANSFERASE
(Agrobacterium
fabrum) 		5 / 6 LEU A 148
GLY A 144
HIS A 159
ASN A 138
ILE A 184
 None
 1.18A 1xf1B-2igtA:
undetectable		 1xf1B-2igtA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 2igt SAM DEPENDENT
METHYLTRANSFERASE
(Agrobacterium
fabrum) 		5 / 12 CYH A 237
MET A 233
PHE A 140
ALA A 191
ILE A 167
 None
None
SAM  A1001 (-4.4A)
SAM  A1001 (-3.6A)
ACY  A1009 (-4.5A)
 1.31A 2bjfA-2igtA:
undetectable		 2bjfA-2igtA:
21.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2igt SAM DEPENDENT
METHYLTRANSFERASE
(Agrobacterium
fabrum) 		12 / 12 PHE A 113
PHE A 140
TYR A 142
ALA A 162
SER A 163
ALA A 166
ALA A 191
PRO A 213
GLY A 216
GLY A 218
TRP A 224
TYR A 253
 FMT  A1013 ( 3.5A)
SAM  A1001 (-4.4A)
FMT  A1013 ( 4.7A)
SAM  A1001 (-3.5A)
ACY  A1008 ( 2.6A)
SAM  A1001 ( 3.9A)
SAM  A1001 (-3.6A)
SAM  A1001 (-3.2A)
SAM  A1001 (-3.5A)
SAM  A1001 (-3.7A)
None
SAM  A1001 (-4.7A)
 0.11A 2igtA-2igtA:
55.4		 2igtA-2igtA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 2igt SAM DEPENDENT
METHYLTRANSFERASE
(Agrobacterium
fabrum) 		3 / 3 ASP A 161
ASP A 190
ASP A 211
 SAM  A1001 (-2.9A)
SAM  A1001 (-3.7A)
SAM  A1001 (-2.8A)
 0.04A 2igtA-2igtA:
55.4		 2igtA-2igtA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2igt SAM DEPENDENT
METHYLTRANSFERASE
(Agrobacterium
fabrum) 		12 / 12 PHE A 113
PHE A 140
TYR A 142
ALA A 162
SER A 163
ALA A 166
ALA A 191
PRO A 213
GLY A 216
GLY A 218
TRP A 224
TYR A 253
 FMT  A1013 ( 3.5A)
SAM  A1001 (-4.4A)
FMT  A1013 ( 4.7A)
SAM  A1001 (-3.5A)
ACY  A1008 ( 2.6A)
SAM  A1001 ( 3.9A)
SAM  A1001 (-3.6A)
SAM  A1001 (-3.2A)
SAM  A1001 (-3.5A)
SAM  A1001 (-3.7A)
None
SAM  A1001 (-4.7A)
 0.13A 2igtB-2igtA:
52.2		 2igtB-2igtA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 2igt SAM DEPENDENT
METHYLTRANSFERASE
(Agrobacterium
fabrum) 		3 / 3 ASP A 161
ASP A 190
ASP A 211
 SAM  A1001 (-2.9A)
SAM  A1001 (-3.7A)
SAM  A1001 (-2.8A)
 0.07A 2igtB-2igtA:
52.2		 2igtB-2igtA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2igt SAM DEPENDENT
METHYLTRANSFERASE
(Agrobacterium
fabrum) 		6 / 12 HIS A 109
PHE A 140
TYR A 142
ALA A 162
ALA A 191
GLY A 218
 FMT  A1013 (-4.1A)
SAM  A1001 (-4.4A)
FMT  A1013 ( 4.7A)
SAM  A1001 (-3.5A)
SAM  A1001 (-3.6A)
SAM  A1001 (-3.7A)
 1.39A 2igtC-2igtA:
51.6		 2igtC-2igtA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2igt SAM DEPENDENT
METHYLTRANSFERASE
(Agrobacterium
fabrum) 		11 / 12 PHE A 113
PHE A 140
TYR A 142
ALA A 162
SER A 163
ALA A 166
ALA A 191
PRO A 213
GLY A 218
TRP A 224
TYR A 253
 FMT  A1013 ( 3.5A)
SAM  A1001 (-4.4A)
FMT  A1013 ( 4.7A)
SAM  A1001 (-3.5A)
ACY  A1008 ( 2.6A)
SAM  A1001 ( 3.9A)
SAM  A1001 (-3.6A)
SAM  A1001 (-3.2A)
SAM  A1001 (-3.7A)
None
SAM  A1001 (-4.7A)
 0.08A 2igtC-2igtA:
51.6		 2igtC-2igtA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IGT_C_SAMC1003_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 2igt SAM DEPENDENT
METHYLTRANSFERASE
(Agrobacterium
fabrum) 		4 / 4 ASP A 161
ASP A 190
ASP A 211
GLY A 216
 SAM  A1001 (-2.9A)
SAM  A1001 (-3.7A)
SAM  A1001 (-2.8A)
SAM  A1001 (-3.5A)
 0.07A 2igtC-2igtA:
51.6		 2igtC-2igtA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2igt SAM DEPENDENT
METHYLTRANSFERASE
(Agrobacterium
fabrum) 		5 / 12 GLY A 247
SER A 304
ILE A 208
LEU A 241
ARG A 238
 None
 1.21A 3iv6D-2igtA:
12.1		 3iv6D-2igtA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2igt SAM DEPENDENT
METHYLTRANSFERASE
(Agrobacterium
fabrum) 		5 / 12 ALA A 130
SER A 242
LEU A 241
ILE A 207
THR A 129
 None
 1.20A 3qfxA-2igtA:
2.5		 3qfxA-2igtA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROZ_A_NCAA266_0
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 2igt SAM DEPENDENT
METHYLTRANSFERASE
(Agrobacterium
fabrum) 		4 / 6 LEU A 230
ALA A 191
LEU A 139
THR A 210
 None
SAM  A1001 (-3.6A)
None
None
 1.01A 3rozA-2igtA:
5.7		 3rozA-2igtA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA802_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 2igt SAM DEPENDENT
METHYLTRANSFERASE
(Agrobacterium
fabrum) 		6 / 9 PHE A 140
TYR A 142
ASP A 161
SER A 163
ASP A 190
PRO A 213
 SAM  A1001 (-4.4A)
FMT  A1013 ( 4.7A)
SAM  A1001 (-2.9A)
ACY  A1008 ( 2.6A)
SAM  A1001 (-3.7A)
SAM  A1001 (-3.2A)
 0.63A 3v8vA-2igtA:
20.1		 3v8vA-2igtA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB802_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 2igt SAM DEPENDENT
METHYLTRANSFERASE
(Agrobacterium
fabrum) 		6 / 12 PHE A 140
TYR A 142
SER A 163
ASP A 190
ASP A 211
PRO A 213
 SAM  A1001 (-4.4A)
FMT  A1013 ( 4.7A)
ACY  A1008 ( 2.6A)
SAM  A1001 (-3.7A)
SAM  A1001 (-2.8A)
SAM  A1001 (-3.2A)
 0.76A 3v8vB-2igtA:
20.6		 3v8vB-2igtA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 2igt SAM DEPENDENT
METHYLTRANSFERASE
(Agrobacterium
fabrum) 		4 / 6 GLY A  32
TRP A  52
GLU A 286
ARG A 296
 None
 1.29A 4bqfA-2igtA:
undetectable		 4bqfA-2igtA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 2igt SAM DEPENDENT
METHYLTRANSFERASE
(Agrobacterium
fabrum) 		4 / 6 LEU A  16
LEU A 282
SER A 301
THR A 251
 ACY  A1010 (-4.9A)
None
None
None
 0.74A 4ikiB-2igtA:
undetectable		 4ikiB-2igtA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 2igt SAM DEPENDENT
METHYLTRANSFERASE
(Agrobacterium
fabrum) 		4 / 7 LEU A  16
LEU A 282
SER A 301
THR A 251
 ACY  A1010 (-4.9A)
None
None
None
 0.80A 4ikjA-2igtA:
undetectable
4ikjB-2igtA:
undetectable		 4ikjA-2igtA:
17.95
4ikjB-2igtA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 2igt SAM DEPENDENT
METHYLTRANSFERASE
(Agrobacterium
fabrum) 		4 / 8 LEU A  16
LEU A 282
SER A 301
THR A 251
 ACY  A1010 (-4.9A)
None
None
None
 0.78A 4ikjA-2igtA:
undetectable
4ikjB-2igtA:
undetectable		 4ikjA-2igtA:
17.95
4ikjB-2igtA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 2igt SAM DEPENDENT
METHYLTRANSFERASE
(Agrobacterium
fabrum) 		3 / 3 GLU A  10
ARG A 267
HIS A 263
 None
 0.80A 4kf9A-2igtA:
undetectable		 4kf9A-2igtA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 2igt SAM DEPENDENT
METHYLTRANSFERASE
(Agrobacterium
fabrum) 		5 / 12 PHE A 140
GLY A 141
ASP A 161
ASP A 211
PRO A 213
 SAM  A1001 (-4.4A)
None
SAM  A1001 (-2.9A)
SAM  A1001 (-2.8A)
SAM  A1001 (-3.2A)
 1.14A 4rtsA-2igtA:
9.7		 4rtsA-2igtA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 2igt SAM DEPENDENT
METHYLTRANSFERASE
(Agrobacterium
fabrum) 		5 / 12 PHE A 140
GLY A 141
ASP A 161
ASP A 211
TYR A 253
 SAM  A1001 (-4.4A)
None
SAM  A1001 (-2.9A)
SAM  A1001 (-2.8A)
SAM  A1001 (-4.7A)
 1.26A 4rtsA-2igtA:
9.7		 4rtsA-2igtA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 2igt SAM DEPENDENT
METHYLTRANSFERASE
(Agrobacterium
fabrum) 		5 / 12 GLY A 141
TYR A 142
SER A 163
ALA A 191
ASP A 211
 None
FMT  A1013 ( 4.7A)
ACY  A1008 ( 2.6A)
SAM  A1001 (-3.6A)
SAM  A1001 (-2.8A)
 1.29A 4ymgB-2igtA:
13.9		 4ymgB-2igtA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 2igt SAM DEPENDENT
METHYLTRANSFERASE
(Agrobacterium
fabrum) 		5 / 12 LEU A 248
THR A 269
PRO A 243
SER A 242
ALA A 245
 None
 1.16A 4ypmA-2igtA:
undetectable		 4ypmA-2igtA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_1
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 2igt SAM DEPENDENT
METHYLTRANSFERASE
(Agrobacterium
fabrum) 		4 / 7 TYR A 253
HIS A 119
TRP A 120
TYR A  38
 SAM  A1001 (-4.7A)
None
None
None
 0.80A 5dlvB-2igtA:
undetectable		 5dlvB-2igtA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_1
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 2igt SAM DEPENDENT
METHYLTRANSFERASE
(Agrobacterium
fabrum) 		4 / 7 TYR A 253
PHE A 113
HIS A 119
TRP A 120
 SAM  A1001 (-4.7A)
FMT  A1013 ( 3.5A)
None
None
 1.24A 5dlvB-2igtA:
undetectable		 5dlvB-2igtA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2igt SAM DEPENDENT
METHYLTRANSFERASE
(Agrobacterium
fabrum) 		5 / 12 ASP A 190
ASP A 211
PRO A 213
PHE A 140
GLY A 141
 SAM  A1001 (-3.7A)
SAM  A1001 (-2.8A)
SAM  A1001 (-3.2A)
SAM  A1001 (-4.4A)
None
 1.13A 5hfjA-2igtA:
3.3		 5hfjA-2igtA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 2igt SAM DEPENDENT
METHYLTRANSFERASE
(Agrobacterium
fabrum) 		4 / 7 VAL A 160
ARG A 197
GLU A 189
ARG A 185
 None
GOL  A1005 (-3.9A)
GOL  A1005 ( 3.1A)
GOL  A1005 ( 4.3A)
 0.97A 5umwB-2igtA:
undetectable
5umwE-2igtA:
undetectable		 5umwB-2igtA:
14.77
5umwE-2igtA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 2igt SAM DEPENDENT
METHYLTRANSFERASE
(Agrobacterium
fabrum) 		4 / 4 ILE A 208
LEU A 123
HIS A 159
ALA A 146
 None
 0.99A 6ck2C-2igtA:
undetectable
6ck2D-2igtA:
undetectable		 6ck2C-2igtA:
3.63
6ck2D-2igtA:
7.03