SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ihd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 2ihd REGULATOR OF
G-PROTEIN SIGNALING
8
(Homo
sapiens) 		3 / 3 ARG A  71
VAL A 121
GLY A 148
 None
None
CL  A   1 ( 4.2A)
 0.43A 2avvE-2ihdA:
undetectable		 2avvE-2ihdA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 2ihd REGULATOR OF
G-PROTEIN SIGNALING
8
(Homo
sapiens) 		4 / 6 SER A  79
ARG A  71
PHE A  70
PHE A  57
 None
 1.12A 2qeiA-2ihdA:
2.9		 2qeiA-2ihdA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 2ihd REGULATOR OF
G-PROTEIN SIGNALING
8
(Homo
sapiens) 		5 / 11 ILE A 123
VAL A 113
PHE A 112
VAL A 121
ILE A 108
 None
 1.24A 3rf4A-2ihdA:
undetectable
3rf4C-2ihdA:
undetectable		 3rf4A-2ihdA:
19.75
3rf4C-2ihdA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2ihd REGULATOR OF
G-PROTEIN SIGNALING
8
(Homo
sapiens) 		3 / 3 PHE A 112
ILE A 108
ASP A 144
 None
 0.74A 5cswB-2ihdA:
2.9		 5cswB-2ihdA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 2ihd REGULATOR OF
G-PROTEIN SIGNALING
8
(Homo
sapiens) 		5 / 12 PHE A  57
LEU A  61
LEU A  87
ARG A  71
LEU A 163
 None
 1.11A 5ljeA-2ihdA:
undetectable		 5ljeA-2ihdA:
22.02