SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ihf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 2ihf SINGLE-STRANDED
DNA-BINDING PROTEIN
(Thermus
aquaticus) 		5 / 12 GLY A 135
GLY A   4
LEU A 157
LEU A 174
VAL A 176
 None
 0.91A 2yqzB-2ihfA:
undetectable		 2yqzB-2ihfA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2ihf SINGLE-STRANDED
DNA-BINDING PROTEIN
(Thermus
aquaticus) 		5 / 8 LEU A 189
VAL A 197
LEU A 224
VAL A 176
LEU A 155
 None
 1.32A 3kp6A-2ihfA:
undetectable
3kp6B-2ihfA:
undetectable		 3kp6A-2ihfA:
21.40
3kp6B-2ihfA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2ihf SINGLE-STRANDED
DNA-BINDING PROTEIN
(Thermus
aquaticus) 		5 / 8 LEU A 201
VAL A 197
LEU A 133
VAL A 176
ARG A 218
 None
 1.26A 3kp6A-2ihfA:
undetectable
3kp6B-2ihfA:
undetectable		 3kp6A-2ihfA:
21.40
3kp6B-2ihfA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2ihf SINGLE-STRANDED
DNA-BINDING PROTEIN
(Thermus
aquaticus) 		3 / 3 VAL A 219
HIS A 172
VAL A 159
 None
 0.64A 5jmnC-2ihfA:
undetectable		 5jmnC-2ihfA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2ihf SINGLE-STRANDED
DNA-BINDING PROTEIN
(Thermus
aquaticus) 		4 / 6 LEU A 196
VAL A  78
MET A   1
GLY A   4
 None
 1.05A 6hd4B-2ihfA:
undetectable		 6hd4B-2ihfA:
16.16