SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ihm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 2ihm DNA POLYMERASE MU
(Mus
musculus) 		5 / 12 ILE A 335
LEU A 394
VAL A 360
LEU A 354
ILE A 302
 None
 0.96A 1df7A-2ihmA:
undetectable		 1df7A-2ihmA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_3
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 2ihm DNA POLYMERASE MU
(Mus
musculus) 		4 / 5 LEU A 347
VAL A 350
LEU A 354
GLN A 357
 None
 0.64A 1fbmE-2ihmA:
undetectable		 1fbmE-2ihmA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2ihm DNA POLYMERASE MU
(Mus
musculus) 		4 / 5 SER A 426
THR A 336
GLU A 340
GLY A 341
 None
 1.33A 1icrA-2ihmA:
1.7
1icrB-2ihmA:
undetectable		 1icrA-2ihmA:
21.49
1icrB-2ihmA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2ihm DNA POLYMERASE MU
(Mus
musculus) 		4 / 5 GLU A 340
GLY A 341
SER A 426
THR A 336
 None
 1.34A 1icrA-2ihmA:
1.7
1icrB-2ihmA:
undetectable		 1icrA-2ihmA:
21.49
1icrB-2ihmA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 2ihm DNA POLYMERASE MU
(Mus
musculus) 		4 / 8 TYR A 362
ARG A 418
TYR A 282
HIS A 366
 None
 1.23A 1nx9A-2ihmA:
undetectable		 1nx9A-2ihmA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_B_AICB5002_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 2ihm DNA POLYMERASE MU
(Mus
musculus) 		4 / 8 TYR A 362
ARG A 418
TYR A 282
HIS A 366
 None
 1.23A 1nx9B-2ihmA:
undetectable		 1nx9B-2ihmA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 2ihm DNA POLYMERASE MU
(Mus
musculus) 		4 / 8 TYR A 362
ARG A 418
TYR A 282
HIS A 366
 None
 1.25A 1nx9C-2ihmA:
undetectable		 1nx9C-2ihmA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 2ihm DNA POLYMERASE MU
(Mus
musculus) 		4 / 8 TYR A 362
ARG A 418
TYR A 282
HIS A 366
 None
 1.24A 1nx9D-2ihmA:
undetectable		 1nx9D-2ihmA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ihm DNA POLYMERASE MU
(Mus
musculus) 		5 / 12 LEU A 189
VAL A 185
PHE A 205
ALA A 183
HIS A 151
 None
 1.27A 1q23A-2ihmA:
undetectable
1q23B-2ihmA:
undetectable		 1q23A-2ihmA:
18.80
1q23B-2ihmA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 2ihm DNA POLYMERASE MU
(Mus
musculus) 		4 / 5 SER A 188
GLU A 445
TYR A 141
SER A 178
 None
 1.35A 1vidA-2ihmA:
undetectable		 1vidA-2ihmA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 2ihm DNA POLYMERASE MU
(Mus
musculus) 		4 / 6 SER A 188
GLU A 445
TYR A 141
SER A 178
 None
 1.36A 2cl5B-2ihmA:
undetectable		 2cl5B-2ihmA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 2ihm DNA POLYMERASE MU
(Mus
musculus) 		4 / 6 SER A 188
GLU A 445
TYR A 141
SER A 178
 None
 1.39A 2zvjA-2ihmA:
undetectable		 2zvjA-2ihmA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 2ihm DNA POLYMERASE MU
(Mus
musculus) 		4 / 6 LEU A 176
GLU A 173
SER A 180
PHE A 441
 None
 1.43A 3i9jB-2ihmA:
undetectable		 3i9jB-2ihmA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 2ihm DNA POLYMERASE MU
(Mus
musculus) 		3 / 3 ASP A 330
ARG A 418
ARG A 323
 NA  A 902 (-2.5A)
None
D3T  A 538 (-2.8A)
 0.99A 3k37A-2ihmA:
undetectable		 3k37A-2ihmA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2ihm DNA POLYMERASE MU
(Mus
musculus) 		4 / 6 VAL A 185
ILE A 213
MET A 138
ARG A 175
 None
 1.04A 3ms9A-2ihmA:
undetectable		 3ms9A-2ihmA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2ihm DNA POLYMERASE MU
(Mus
musculus) 		4 / 6 VAL A 185
ILE A 213
MET A 138
ARG A 175
 None
 1.08A 3mssA-2ihmA:
undetectable		 3mssA-2ihmA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 2ihm DNA POLYMERASE MU
(Mus
musculus) 		4 / 7 LEU A 298
VAL A 417
LEU A 347
ASP A 420
 None
None
None
NA  A 902 (-3.8A)
 0.85A 3rgfA-2ihmA:
undetectable		 3rgfA-2ihmA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAX_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 2ihm DNA POLYMERASE MU
(Mus
musculus) 		5 / 10 PHE A 179
VAL A 212
ILE A 213
LYS A 187
PHE A 205
 None
 1.24A 4laxA-2ihmA:
undetectable		 4laxA-2ihmA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NNR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)		 2ihm DNA POLYMERASE MU
(Mus
musculus) 		5 / 10 PHE A 179
VAL A 212
ILE A 213
LYS A 187
PHE A 205
 None
 1.24A 4nnrB-2ihmA:
undetectable		 4nnrB-2ihmA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2ihm DNA POLYMERASE MU
(Mus
musculus) 		4 / 6 GLU A 445
GLY A 324
ARG A 322
GLY A 320
 None
None
None
D3T  A 538 (-3.7A)
 0.83A 5cdnA-2ihmA:
2.1
5cdnB-2ihmA:
undetectable		 5cdnA-2ihmA:
20.95
5cdnB-2ihmA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_B_5OGB804_1
(HDAC6 PROTEIN)		 2ihm DNA POLYMERASE MU
(Mus
musculus) 		5 / 12 HIS A 366
HIS A 329
PHE A 391
ASP A 330
ASP A 332
 None
D3T  A 538 (-3.9A)
None
NA  A 902 (-2.5A)
NA  A 902 (-3.2A)
 1.43A 5eenB-2ihmA:
undetectable		 5eenB-2ihmA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_A_LBHA2004_1
(HDAC6 PROTEIN)		 2ihm DNA POLYMERASE MU
(Mus
musculus) 		5 / 12 HIS A 366
HIS A 329
PHE A 391
ASP A 330
ASP A 332
 None
D3T  A 538 (-3.9A)
None
NA  A 902 (-2.5A)
NA  A 902 (-3.2A)
 1.45A 5ef8A-2ihmA:
undetectable		 5ef8A-2ihmA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 2ihm DNA POLYMERASE MU
(Mus
musculus) 		4 / 5 SER A 188
GLU A 445
TYR A 141
SER A 178
 None
 1.41A 5fhrA-2ihmA:
undetectable		 5fhrA-2ihmA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 2ihm DNA POLYMERASE MU
(Mus
musculus) 		5 / 12 ALA A 474
SER A 476
PHE A 431
GLY A 485
LEU A 484
 None
 1.12A 5m54E-2ihmA:
undetectable		 5m54E-2ihmA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGM_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2ihm DNA POLYMERASE MU
(Mus
musculus) 		3 / 3 VAL A 419
VAL A 331
GLN A 299
 None
 0.67A 5qgmA-2ihmA:
undetectable		 5qgmA-2ihmA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGW_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2ihm DNA POLYMERASE MU
(Mus
musculus) 		3 / 3 VAL A 419
VAL A 331
GLN A 299
 None
 0.72A 5qgwA-2ihmA:
undetectable		 5qgwA-2ihmA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH1_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2ihm DNA POLYMERASE MU
(Mus
musculus) 		3 / 3 VAL A 419
VAL A 331
GLN A 299
 None
 0.72A 5qh1A-2ihmA:
undetectable		 5qh1A-2ihmA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH9_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2ihm DNA POLYMERASE MU
(Mus
musculus) 		3 / 3 VAL A 419
VAL A 331
GLN A 299
 None
 0.70A 5qh9A-2ihmA:
undetectable		 5qh9A-2ihmA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHE_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2ihm DNA POLYMERASE MU
(Mus
musculus) 		3 / 3 VAL A 419
VAL A 331
GLN A 299
 None
 0.72A 5qheA-2ihmA:
undetectable		 5qheA-2ihmA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHF_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2ihm DNA POLYMERASE MU
(Mus
musculus) 		3 / 3 VAL A 419
VAL A 331
GLN A 299
 None
 0.71A 5qhfA-2ihmA:
undetectable		 5qhfA-2ihmA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2ihm DNA POLYMERASE MU
(Mus
musculus) 		3 / 3 VAL A 419
VAL A 331
GLN A 299
 None
 0.70A 5qhgA-2ihmA:
undetectable		 5qhgA-2ihmA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 2ihm DNA POLYMERASE MU
(Mus
musculus) 		4 / 7 GLU A 165
TYR A 234
ALA A 251
GLY A 247
 None
None
None
NA  A 900 ( 4.9A)
 1.07A 5uxdA-2ihmA:
2.7		 5uxdA-2ihmA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 2ihm DNA POLYMERASE MU
(Mus
musculus) 		3 / 3 LEU A 446
LEU A 434
ARG A 494
 None
 0.65A 6fgcA-2ihmA:
undetectable		 6fgcA-2ihmA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 2ihm DNA POLYMERASE MU
(Mus
musculus) 		3 / 3 LEU A 446
LEU A 434
ARG A 494
 None
 0.61A 6fgdA-2ihmA:
undetectable		 6fgdA-2ihmA:
22.43