SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ihs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)		 2ihs CG2944-PF, ISOFORM F
(Drosophila
melanogaster) 		5 / 12 LEU A 208
LEU A 185
ALA A 184
SER A 193
ALA A 204
 None
 1.23A 2bxpA-2ihsA:
undetectable		 2bxpA-2ihsA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 2ihs CG2944-PF, ISOFORM F
(Drosophila
melanogaster) 		5 / 10 ILE A 203
ALA A 204
ILE A 195
ILE A  41
TYR A 200
 None
 1.36A 2dm6A-2ihsA:
undetectable
2dm6B-2ihsA:
undetectable		 2dm6A-2ihsA:
22.94
2dm6B-2ihsA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2REZ_A_ACTA156_0
(MULTIFUNCTIONAL
CYCLASE-DEHYDRATASE-
3-O-METHYL
TRANSFERASE TCMN)		 2ihs CG2944-PF, ISOFORM F
(Drosophila
melanogaster) 		4 / 7 THR A 123
TRP A 144
MET A 187
LEU A 185
 None
 1.35A 2rezA-2ihsA:
0.0		 2rezA-2ihsA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2ihs CG2944-PF, ISOFORM F
(Drosophila
melanogaster) 		4 / 5 TYR A 154
VAL A 118
SER A 135
GLY A 149
 None
 1.27A 3v4tA-2ihsA:
undetectable
3v4tD-2ihsA:
undetectable		 3v4tA-2ihsA:
20.49
3v4tD-2ihsA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 2ihs CG2944-PF, ISOFORM F
(Drosophila
melanogaster) 		6 / 12 VAL A 183
LEU A 192
VAL A 217
ILE A 106
GLY A 138
LEU A 208
 None
 1.43A 4y8wC-2ihsA:
undetectable		 4y8wC-2ihsA:
18.06