SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ihy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 2ihy ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Staphylococcus
aureus) 		5 / 12 ILE A   8
GLN A 225
VAL A 200
LEU A  44
ILE A  25
 None
 1.22A 1kqwA-2ihyA:
undetectable		 1kqwA-2ihyA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA156_1
(CALMODULIN)		 2ihy ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Staphylococcus
aureus) 		5 / 8 ILE A 214
LEU A 232
ILE A 207
GLU A 205
ILE A  32
 None
 0.99A 1linA-2ihyA:
undetectable		 1linA-2ihyA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 2ihy ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Staphylococcus
aureus) 		4 / 6 LEU A 185
LEU A 182
ILE A 153
ARG A 150
 None
 0.71A 2rlfA-2ihyA:
undetectable
2rlfB-2ihyA:
undetectable		 2rlfA-2ihyA:
10.39
2rlfB-2ihyA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 2ihy ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Staphylococcus
aureus) 		4 / 6 LEU A 185
LEU A 182
ILE A 153
ARG A 150
 None
 0.68A 2rlfC-2ihyA:
undetectable
2rlfD-2ihyA:
undetectable		 2rlfC-2ihyA:
10.39
2rlfD-2ihyA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_B_J01B500_1
(ORF12)		 2ihy ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Staphylococcus
aureus) 		5 / 9 VAL A 200
ILE A 198
LEU A 157
GLY A  81
ALA A 156
 None
 1.44A 2xf3B-2ihyA:
undetectable		 2xf3B-2ihyA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_B_J01B500_1
(ORF12)		 2ihy ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Staphylococcus
aureus) 		5 / 9 VAL A 200
ILE A 198
LEU A 157
GLY A  81
ALA A 156
 None
 1.47A 2xfsB-2ihyA:
undetectable		 2xfsB-2ihyA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1436_1
(ORF12)		 2ihy ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Staphylococcus
aureus) 		5 / 9 VAL A 200
ILE A 198
LEU A 157
GLY A  81
ALA A 156
 None
 1.46A 2xh9B-2ihyA:
undetectable		 2xh9B-2ihyA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2ihy ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Staphylococcus
aureus) 		5 / 12 ILE A 165
ARG A  10
LEU A  44
ILE A   3
LEU A   5
 None
 0.91A 3k2hB-2ihyA:
undetectable		 3k2hB-2ihyA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2ihy ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Staphylococcus
aureus) 		3 / 3 GLY A  38
GLY A  40
THR A  42
 SO4  A 301 (-3.4A)
SO4  A 301 (-3.5A)
SO4  A 301 (-3.9A)
 0.44A 3si7B-2ihyA:
15.7		 3si7B-2ihyA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 2ihy ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Staphylococcus
aureus) 		5 / 10 ALA A  50
ARG A  77
LEU A   5
LEU A  61
ILE A   3
 None
 1.17A 3wdmD-2ihyA:
undetectable		 3wdmD-2ihyA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2ihy ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Staphylococcus
aureus) 		4 / 7 GLU A  95
PHE A  91
HIS A 124
VAL A 130
 None
 1.04A 4a97A-2ihyA:
undetectable		 4a97A-2ihyA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2ihy ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Staphylococcus
aureus) 		4 / 6 GLU A  95
PHE A  91
HIS A 124
VAL A 130
 None
 1.09A 4a97I-2ihyA:
undetectable		 4a97I-2ihyA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_1
(WBDD)		 2ihy ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Staphylococcus
aureus) 		4 / 6 ARG A 253
ASP A 174
GLU A 147
LEU A 182
 None
 1.24A 4ax8A-2ihyA:
undetectable		 4ax8A-2ihyA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 2ihy ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Staphylococcus
aureus) 		5 / 12 LEU A  36
PHE A 203
ILE A 204
GLU A 205
ASN A 236
 None
 0.83A 4fr0A-2ihyA:
undetectable		 4fr0A-2ihyA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 2ihy ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Staphylococcus
aureus) 		4 / 5 VAL A 200
LEU A  45
ILE A 165
LEU A 166
 None
 0.83A 4mghA-2ihyA:
undetectable		 4mghA-2ihyA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 2ihy ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Staphylococcus
aureus) 		3 / 3 LEU A 185
ASP A 190
ILE A 207
 None
 0.70A 4xi3D-2ihyA:
undetectable		 4xi3D-2ihyA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2ihy ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Staphylococcus
aureus) 		4 / 7 MET A 237
PHE A 241
ALA A  39
LEU A  36
 None
None
SO4  A 301 (-3.7A)
None
 1.10A 4xk8A-2ihyA:
undetectable		 4xk8A-2ihyA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2ihy ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Staphylococcus
aureus) 		4 / 7 ILE A 184
LEU A 188
ARG A 178
LEU A 166
 None
 0.91A 5b1aA-2ihyA:
undetectable
5b1aJ-2ihyA:
undetectable		 5b1aA-2ihyA:
19.92
5b1aJ-2ihyA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2ihy ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Staphylococcus
aureus) 		4 / 7 ILE A 184
LEU A 188
ARG A 178
LEU A 166
 None
 0.92A 5b3sA-2ihyA:
undetectable
5b3sJ-2ihyA:
undetectable		 5b3sA-2ihyA:
19.92
5b3sJ-2ihyA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ihy ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Staphylococcus
aureus) 		4 / 4 LEU A  45
ARG A  77
ILE A 165
PHE A  82
 None
 1.14A 5kirB-2ihyA:
undetectable		 5kirB-2ihyA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 2ihy ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Staphylococcus
aureus) 		4 / 5 GLU A  95
SER A 103
ARG A 155
GLY A 104
 None
 1.11A 5kprA-2ihyA:
undetectable		 5kprA-2ihyA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2ihy ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Staphylococcus
aureus) 		4 / 7 ILE A 184
LEU A 188
ARG A 178
LEU A 166
 None
 0.95A 5zcpA-2ihyA:
undetectable
5zcpJ-2ihyA:
undetectable		 5zcpA-2ihyA:
19.92
5zcpJ-2ihyA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2ihy ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Staphylococcus
aureus) 		4 / 7 ILE A 184
LEU A 188
ARG A 178
LEU A 166
 None
 0.91A 5zcqA-2ihyA:
undetectable
5zcqJ-2ihyA:
undetectable		 5zcqA-2ihyA:
19.92
5zcqJ-2ihyA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 2ihy ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Staphylococcus
aureus) 		4 / 9 VAL A  76
LEU A  45
VAL A  83
SER A  84
 None
 0.91A 6c2mD-2ihyA:
undetectable		 6c2mD-2ihyA:
16.67