SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iic'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 2iic ALPHA-11 GIARDIN
(Giardia
intestinalis) 		3 / 3 ARG A 105
VAL A  79
GLY A 257
 None
 0.60A 2avvE-2iicA:
undetectable		 2avvE-2iicA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 2iic ALPHA-11 GIARDIN
(Giardia
intestinalis) 		5 / 12 ASP A  89
ASN A 244
ILE A  99
ASP A  95
ARG A 254
 None
 1.47A 2qmjA-2iicA:
undetectable		 2qmjA-2iicA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 2iic ALPHA-11 GIARDIN
(Giardia
intestinalis) 		4 / 5 ALA A 239
GLN A 251
ILE A 255
ARG A 254
 None
 1.40A 2z0aA-2iicA:
0.5		 2z0aA-2iicA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2iic ALPHA-11 GIARDIN
(Giardia
intestinalis) 		4 / 6 GLU A  18
ILE A  56
GLU A  62
ASN A 290
 None
None
CA  A 401 (-3.8A)
None
 0.96A 3pgyA-2iicA:
undetectable
3pgyB-2iicA:
undetectable		 3pgyA-2iicA:
22.59
3pgyB-2iicA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_A_ACRA701_1
(ALPHA-GLUCOSIDASE)		 2iic ALPHA-11 GIARDIN
(Giardia
intestinalis) 		5 / 12 ASP A  89
ILE A 220
ILE A  99
ASP A  95
ARG A 254
 None
 1.20A 3phaA-2iicA:
undetectable		 3phaA-2iicA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)		 2iic ALPHA-11 GIARDIN
(Giardia
intestinalis) 		5 / 12 ASP A  89
ILE A 220
ILE A  99
ASP A  95
ARG A 254
 None
 1.26A 3phaB-2iicA:
undetectable		 3phaB-2iicA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 2iic ALPHA-11 GIARDIN
(Giardia
intestinalis) 		3 / 3 VAL A  96
ALA A 100
PHE A 259
 None
 0.93A 4olbA-2iicA:
undetectable		 4olbA-2iicA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2iic ALPHA-11 GIARDIN
(Giardia
intestinalis) 		3 / 3 VAL A  96
ALA A 100
PHE A 259
 None
 0.91A 4z4iA-2iicA:
undetectable		 4z4iA-2iicA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 2iic ALPHA-11 GIARDIN
(Giardia
intestinalis) 		3 / 3 ASP A 211
GLU A 168
SER A 238
 None
 0.80A 5bw4B-2iicA:
undetectable		 5bw4B-2iicA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GPG_A_RAPA301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 2iic ALPHA-11 GIARDIN
(Giardia
intestinalis) 		5 / 11 LEU A 258
VAL A  79
ILE A  80
ALA A 141
ILE A 142
 None
 1.15A 5gpgA-2iicA:
undetectable		 5gpgA-2iicA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2iic ALPHA-11 GIARDIN
(Giardia
intestinalis) 		3 / 3 VAL A  96
ALA A 100
PHE A 259
 None
 0.92A 5js1A-2iicA:
undetectable		 5js1A-2iicA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA606_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 2iic ALPHA-11 GIARDIN
(Giardia
intestinalis) 		4 / 5 GLU A 194
PHE A 193
HIS A 222
THR A 197
 None
 1.38A 6b58A-2iicA:
3.0		 6b58A-2iicA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 2iic ALPHA-11 GIARDIN
(Giardia
intestinalis) 		3 / 3 ILE A  93
ASN A 214
CYH A 219
 None
 0.79A 6bp4A-2iicA:
undetectable		 6bp4A-2iicA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9X_A_VOGA701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 2iic ALPHA-11 GIARDIN
(Giardia
intestinalis) 		5 / 12 ASP A  89
ILE A 220
ILE A  99
ASP A  95
ARG A 254
 None
 1.29A 6c9xA-2iicA:
undetectable		 6c9xA-2iicA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9X_B_VOGB701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 2iic ALPHA-11 GIARDIN
(Giardia
intestinalis) 		5 / 12 ASP A  89
ILE A 220
ILE A  99
ASP A  95
ARG A 254
 None
 1.29A 6c9xB-2iicA:
undetectable		 6c9xB-2iicA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_B_VOGB701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 2iic ALPHA-11 GIARDIN
(Giardia
intestinalis) 		5 / 12 ASP A  89
ILE A 220
ILE A  99
ASP A  95
ARG A 254
 None
 1.22A 6c9zB-2iicA:
undetectable		 6c9zB-2iicA:
19.10