SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iih'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 2iih MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
C
(Thermus
thermophilus) 		5 / 10 ALA A  99
THR A 100
ALA A  26
ALA A  28
ALA A  64
 None
 1.05A 2f16K-2iihA:
2.2
2f16L-2iihA:
undetectable		 2f16K-2iihA:
23.08
2f16L-2iihA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 2iih MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
C
(Thermus
thermophilus) 		5 / 10 ALA A  99
THR A 100
ALA A  26
ALA A  28
ALA A  64
 None
 1.05A 2f16Y-2iihA:
undetectable
2f16Z-2iihA:
undetectable		 2f16Y-2iihA:
23.08
2f16Z-2iihA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)		 2iih MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
C
(Thermus
thermophilus) 		4 / 4 LEU A  34
ALA A  41
VAL A  47
PRO A  52
 None
 1.24A 3gv1B-2iihA:
undetectable		 3gv1B-2iihA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2iih MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
C
(Thermus
thermophilus) 		5 / 9 ALA A  30
ILE A 137
ALA A  56
CYH A 117
ALA A 120
 None
 0.95A 4lbgB-2iihA:
undetectable		 4lbgB-2iihA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2iih MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
C
(Thermus
thermophilus) 		4 / 8 LEU A 135
LEU A  42
THR A  35
LEU A  34
 None
 0.74A 4z90F-2iihA:
undetectable
4z90G-2iihA:
undetectable
4z90H-2iihA:
undetectable
4z90I-2iihA:
undetectable
4z90J-2iihA:
undetectable		 4z90F-2iihA:
18.38
4z90G-2iihA:
18.38
4z90H-2iihA:
18.38
4z90I-2iihA:
18.38
4z90J-2iihA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 2iih MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
C
(Thermus
thermophilus) 		5 / 11 GLY A  60
ALA A  59
ALA A 120
ILE A  97
VAL A  84
 None
 1.06A 5yk2A-2iihA:
undetectable		 5yk2A-2iihA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_2
(RIFAMPIN
MONOOXYGENASE)		 2iih MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
C
(Thermus
thermophilus) 		4 / 4 GLN A 139
VAL A 136
ARG A  85
ARG A 141
 None
 1.25A 6brdA-2iihA:
undetectable		 6brdA-2iihA:
20.38