SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iii'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OHT_A_1N1A1000_1 (P38A)	2iii	S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME (Aquifex aeolicus)	6 / 12	VAL A 16 ALA A 77 ILE A 27 THR A 70 LEU A 30 ASP A 26	None None None None None MG A 136 (-2.6A)	0.98A	3ohtA-2iiiA: undetectable	3ohtA-2iiiA: 16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QYN_A_RTLA201_0 (RETINOL-BINDING PROTEIN 2)	2iii	S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME (Aquifex aeolicus)	5 / 12	MET A 94 ILE A 98 ALA A 11 THR A 70 LEU A 101	None	1.09A	4qynA-2iiiA: undetectable	4qynA-2iiiA: 21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QZU_A_RTLA201_0 (RETINOL-BINDING PROTEIN 2)	2iii	S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME (Aquifex aeolicus)	5 / 12	ILE A 98 ALA A 11 THR A 70 LEU A 101 LEU A 31	None	1.03A	4qzuA-2iiiA: undetectable	4qzuA-2iiiA: 21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QZU_C_RTLC201_0 (RETINOL-BINDING PROTEIN 2)	2iii	S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME (Aquifex aeolicus)	5 / 12	ALA A 55 VAL A 81 LEU A 31 LEU A 13 LEU A 101	None	0.97A	4qzuC-2iiiA: undetectable	4qzuC-2iiiA: 21.28

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3OHT_A_1N1A1000_1","P38A","2iii","S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME","Aquifex aeolicus",6,"VAL A  16;ALA A  77;ILE A  27;THR A  70;LEU A  30;ASP A  26","None;None;None;None;None; MG A 136 (-2.6A)","0.98A","3ohtA-2iiiA:undetectable","3ohtA-2iiiA:16.04"],["4QYN_A_RTLA201_0","RETINOL-BINDING PROTEIN 2","2iii","S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME","Aquifex aeolicus",5,"MET A  94;ILE A  98;ALA A  11;THR A  70;LEU A 101","None","1.09A","4qynA-2iiiA:undetectable","4qynA-2iiiA:21.28"],["4QZU_A_RTLA201_0","RETINOL-BINDING PROTEIN 2","2iii","S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME","Aquifex aeolicus",5,"ILE A  98;ALA A  11;THR A  70;LEU A 101;LEU A  31","None","1.03A","4qzuA-2iiiA:undetectable","4qzuA-2iiiA:21.28"],["4QZU_C_RTLC201_0","RETINOL-BINDING PROTEIN 2","2iii","S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME","Aquifex aeolicus",5,"ALA A  55;VAL A  81;LEU A  31;LEU A  13;LEU A 101","None","0.97A","4qzuC-2iiiA:undetectable","4qzuC-2iiiA:21.28"]]