SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iik'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1002_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL
(Homo
sapiens) 		5 / 12 VAL A 406
VAL A  38
TYR A 142
SER A 132
LEU A 127
 None
 1.20A 1fm4A-2iikA:
undetectable		 1fm4A-2iikA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL
(Homo
sapiens) 		4 / 7 ALA A 129
SER A 132
ILE A 133
ILE A  86
 None
 0.70A 1yc5A-2iikA:
undetectable		 1yc5A-2iikA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL
(Homo
sapiens) 		5 / 12 GLY A 149
GLY A 384
GLY A 126
ALA A 129
ASN A 346
 None
 1.06A 2dpmA-2iikA:
undetectable		 2dpmA-2iikA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL
(Homo
sapiens) 		4 / 7 ALA A 402
ARG A 401
ASP A 339
TYR A 403
 None
 1.24A 2e5dA-2iikA:
undetectable
2e5dB-2iikA:
undetectable		 2e5dA-2iikA:
23.67
2e5dB-2iikA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL
(Homo
sapiens) 		4 / 5 ALA A 129
ALA A 101
ALA A 104
VAL A  68
 None
 0.89A 2nyrB-2iikA:
undetectable		 2nyrB-2iikA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL
(Homo
sapiens) 		5 / 12 GLY A 377
SER A 277
ALA A 373
ASN A 346
GLY A 126
 None
 1.16A 2vmyB-2iikA:
undetectable		 2vmyB-2iikA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1467_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL
(Homo
sapiens) 		4 / 5 ARG A  45
ASP A 246
ILE A 249
GLU A 223
 None
 0.88A 2xrzA-2iikA:
undetectable
2xrzB-2iikA:
undetectable		 2xrzA-2iikA:
22.44
2xrzB-2iikA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL
(Homo
sapiens) 		5 / 12 ILE A 410
GLY A 384
LEU A  64
PRO A 379
THR A  46
 None
 1.05A 2y7hC-2iikA:
undetectable		 2y7hC-2iikA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL
(Homo
sapiens) 		5 / 11 LEU A 127
ALA A 325
ALA A 417
VAL A 130
LEU A 305
 None
 1.30A 3bszE-2iikA:
undetectable		 3bszE-2iikA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		 2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL
(Homo
sapiens) 		5 / 12 GLY A 248
SER A 280
LEU A 376
SER A 276
ALA A 373
 None
 1.28A 3d91A-2iikA:
undetectable		 3d91A-2iikA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL
(Homo
sapiens) 		4 / 8 ILE A 389
LEU A 392
VAL A  40
GLY A  43
 None
 0.76A 3dcjB-2iikA:
undetectable		 3dcjB-2iikA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL
(Homo
sapiens) 		5 / 10 GLY A 126
GLN A 128
ILE A 286
VAL A 388
VAL A 406
 None
 1.33A 3fhjA-2iikA:
undetectable		 3fhjA-2iikA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL
(Homo
sapiens) 		5 / 10 GLY A 126
GLN A 128
ILE A 286
VAL A 388
VAL A 406
 None
 1.37A 3fhjB-2iikA:
undetectable		 3fhjB-2iikA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL
(Homo
sapiens) 		5 / 10 GLY A 126
GLN A 128
ILE A 286
VAL A 388
VAL A 406
 None
 1.36A 3fhjC-2iikA:
undetectable		 3fhjC-2iikA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL
(Homo
sapiens) 		5 / 10 GLY A 126
GLN A 128
ILE A 286
VAL A 388
VAL A 406
 None
 1.38A 3fhjE-2iikA:
undetectable		 3fhjE-2iikA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL
(Homo
sapiens) 		5 / 9 GLY A 126
GLN A 128
ILE A 286
VAL A 388
VAL A 406
 None
 1.38A 3fi0A-2iikA:
undetectable		 3fi0A-2iikA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL
(Homo
sapiens) 		5 / 9 GLY A 126
GLN A 128
ILE A 286
VAL A 388
VAL A 406
 None
 1.41A 3fi0C-2iikA:
undetectable		 3fi0C-2iikA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_H_TRPH1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL
(Homo
sapiens) 		5 / 9 GLY A 126
GLN A 128
ILE A 286
VAL A 388
VAL A 406
 None
 1.32A 3fi0H-2iikA:
undetectable		 3fi0H-2iikA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_N_TRPN1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL
(Homo
sapiens) 		5 / 9 GLY A 126
GLN A 128
ILE A 286
VAL A 388
VAL A 406
 None
 1.38A 3fi0N-2iikA:
undetectable		 3fi0N-2iikA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA309_1
(BETA-LACTAMASE)		 2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL
(Homo
sapiens) 		4 / 5 ILE A 249
ARG A 397
GLU A 344
GLU A 394
 None
 1.01A 3ny4A-2iikA:
undetectable		 3ny4A-2iikA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_2
(PROTEASE)		 2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL
(Homo
sapiens) 		4 / 7 LEU A 376
ASP A 246
ALA A  47
VAL A  68
 None
 0.95A 3wsjB-2iikA:
undetectable		 3wsjB-2iikA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL
(Homo
sapiens) 		4 / 7 GLU A 223
ILE A 389
PHE A 220
HIS A 378
 None
 1.10A 4a97A-2iikA:
undetectable		 4a97A-2iikA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL
(Homo
sapiens) 		4 / 6 GLU A 223
ILE A 389
PHE A 220
HIS A 378
 None
 1.16A 4a97I-2iikA:
undetectable		 4a97I-2iikA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EVY_B_TOYB201_1
(AMINOGLYCOSIDE
N(6')-ACETYLTRANSFER
ASE TYPE 1)		 2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL
(Homo
sapiens) 		5 / 10 ASN A 368
GLU A 347
ASP A 246
GLU A 223
GLY A 384
 None
 1.35A 4evyA-2iikA:
0.0
4evyB-2iikA:
0.0		 4evyA-2iikA:
21.33
4evyB-2iikA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		 2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL
(Homo
sapiens) 		5 / 11 VAL A 130
ALA A 129
SER A 124
SER A 125
GLY A 384
 None
 1.32A 4mmaA-2iikA:
undetectable		 4mmaA-2iikA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_A_ASCA502_0
(OS09G0567300 PROTEIN)		 2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL
(Homo
sapiens) 		4 / 5 GLU A 394
ARG A 397
PHE A 220
ARG A 386
 None
 1.40A 5jcnA-2iikA:
0.0		 5jcnA-2iikA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL
(Homo
sapiens) 		4 / 6 GLU A 394
ARG A 397
PHE A 220
ARG A 386
 None
 1.42A 5jcnB-2iikA:
undetectable		 5jcnB-2iikA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL
(Homo
sapiens) 		3 / 3 ASP A 281
ASN A  90
GLN A  93
 None
 0.63A 5k7uA-2iikA:
undetectable		 5k7uA-2iikA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL
(Homo
sapiens) 		4 / 6 LEU A 179
ILE A 410
THR A 412
MET A 414
 None
 1.44A 5ljeA-2iikA:
undetectable		 5ljeA-2iikA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL
(Homo
sapiens) 		5 / 12 SER A 207
PHE A 220
ALA A 373
THR A 383
GLU A 394
 None
 1.17A 5vcgA-2iikA:
undetectable		 5vcgA-2iikA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL
(Homo
sapiens) 		4 / 6 GLY A  97
ASP A  62
GLY A  89
GLY A 149
 None
 0.74A 6ag0C-2iikA:
undetectable		 6ag0C-2iikA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL
(Homo
sapiens) 		5 / 12 VAL A 367
PHE A 203
ILE A 195
VAL A 189
VAL A 357
 None
 1.33A 6ap6A-2iikA:
undetectable		 6ap6A-2iikA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL
(Homo
sapiens) 		5 / 12 VAL A 367
PHE A 203
ILE A 195
VAL A 189
VAL A 357
 None
 1.34A 6ap6B-2iikA:
undetectable		 6ap6B-2iikA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL
(Homo
sapiens) 		5 / 10 MET A 153
GLY A 126
SER A 124
ALA A 416
VAL A  91
 None
 1.47A 6hu9L-2iikA:
undetectable
6hu9P-2iikA:
undetectable
6hu9T-2iikA:
undetectable		 6hu9L-2iikA:
22.48
6hu9P-2iikA:
18.94
6hu9T-2iikA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL
(Homo
sapiens) 		4 / 7 ASP A 246
ARG A 386
GLU A 223
GLU A 344
 None
 1.20A 6mn5E-2iikA:
undetectable		 6mn5E-2iikA:
10.51