SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iip'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 2iip NICOTINAMIDE
N-METHYLTRANSFERASE
(Homo
sapiens) 		3 / 3 TRP A 234
ALA A 257
VAL A 194
 None
 0.97A 1bdwA-2iipA:
undetectable
1bdwB-2iipA:
undetectable		 1bdwA-2iipA:
3.94
1bdwB-2iipA:
3.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_A_CHDA459_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2iip NICOTINAMIDE
N-METHYLTRANSFERASE
(Homo
sapiens) 		4 / 6 ASP A  61
LEU A 161
VAL A 160
TYR A  25
 None
None
None
SAH  A4001 (-4.4A)
 0.91A 1s9qA-2iipA:
undetectable		 1s9qA-2iipA:
26.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2G70_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2iip NICOTINAMIDE
N-METHYLTRANSFERASE
(Homo
sapiens) 		6 / 12 TYR A  11
GLN A  70
ASP A 142
VAL A 143
CYH A 165
TYR A 204
 SAH  A4001 (-3.7A)
SAH  A4001 (-4.1A)
SAH  A4001 (-3.7A)
SAH  A4001 (-3.7A)
SAH  A4001 ( 3.8A)
None
 0.46A 2g70A-2iipA:
36.2		 2g70A-2iipA:
36.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2iip NICOTINAMIDE
N-METHYLTRANSFERASE
(Homo
sapiens) 		7 / 7 TYR A  20
TYR A  25
GLY A  65
THR A  67
TYR A  69
ASP A  85
ASN A  90
 SAH  A4001 (-4.6A)
SAH  A4001 (-4.4A)
SAH  A4001 (-3.0A)
SAH  A4001 (-3.5A)
SAH  A4001 (-4.6A)
SAH  A4001 (-2.6A)
SAH  A4001 (-4.0A)
 0.34A 2g70A-2iipA:
36.2		 2g70A-2iipA:
36.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2iip NICOTINAMIDE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 7 TYR A  69
GLY A  65
THR A  67
ASP A  85
ASN A  90
 SAH  A4001 (-4.6A)
SAH  A4001 (-3.0A)
SAH  A4001 (-3.5A)
SAH  A4001 (-2.6A)
SAH  A4001 (-4.0A)
 1.30A 2g70A-2iipA:
36.2		 2g70A-2iipA:
36.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2iip NICOTINAMIDE
N-METHYLTRANSFERASE
(Homo
sapiens) 		6 / 12 TYR A  11
GLN A  70
ASP A 142
VAL A 143
CYH A 165
TYR A 204
 SAH  A4001 (-3.7A)
SAH  A4001 (-4.1A)
SAH  A4001 (-3.7A)
SAH  A4001 (-3.7A)
SAH  A4001 ( 3.8A)
None
 0.46A 2g70B-2iipA:
36.6		 2g70B-2iipA:
36.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2iip NICOTINAMIDE
N-METHYLTRANSFERASE
(Homo
sapiens) 		7 / 7 TYR A  20
TYR A  25
GLY A  65
THR A  67
TYR A  69
ASP A  85
ASN A  90
 SAH  A4001 (-4.6A)
SAH  A4001 (-4.4A)
SAH  A4001 (-3.0A)
SAH  A4001 (-3.5A)
SAH  A4001 (-4.6A)
SAH  A4001 (-2.6A)
SAH  A4001 (-4.0A)
 0.34A 2g70B-2iipA:
36.6		 2g70B-2iipA:
36.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2G72_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2iip NICOTINAMIDE
N-METHYLTRANSFERASE
(Homo
sapiens) 		6 / 12 TYR A  11
THR A  67
ASP A 142
VAL A 143
CYH A 165
TYR A 204
 SAH  A4001 (-3.7A)
SAH  A4001 (-3.5A)
SAH  A4001 (-3.7A)
SAH  A4001 (-3.7A)
SAH  A4001 ( 3.8A)
None
 0.50A 2g72A-2iipA:
36.3		 2g72A-2iipA:
36.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2iip NICOTINAMIDE
N-METHYLTRANSFERASE
(Homo
sapiens) 		6 / 6 TYR A  20
TYR A  25
GLY A  65
TYR A  69
ASP A  85
ASN A  90
 SAH  A4001 (-4.6A)
SAH  A4001 (-4.4A)
SAH  A4001 (-3.0A)
SAH  A4001 (-4.6A)
SAH  A4001 (-2.6A)
SAH  A4001 (-4.0A)
 0.29A 2g72A-2iipA:
36.3		 2g72A-2iipA:
36.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2iip NICOTINAMIDE
N-METHYLTRANSFERASE
(Homo
sapiens) 		6 / 12 TYR A  11
THR A  67
GLN A  70
VAL A 143
CYH A 165
TYR A 204
 SAH  A4001 (-3.7A)
SAH  A4001 (-3.5A)
SAH  A4001 (-4.1A)
SAH  A4001 (-3.7A)
SAH  A4001 ( 3.8A)
None
 0.52A 2g72B-2iipA:
36.7		 2g72B-2iipA:
36.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2iip NICOTINAMIDE
N-METHYLTRANSFERASE
(Homo
sapiens) 		7 / 7 TYR A  20
TYR A  25
GLY A  65
TYR A  69
ASP A  85
ASN A  90
ASP A 142
 SAH  A4001 (-4.6A)
SAH  A4001 (-4.4A)
SAH  A4001 (-3.0A)
SAH  A4001 (-4.6A)
SAH  A4001 (-2.6A)
SAH  A4001 (-4.0A)
SAH  A4001 (-3.7A)
 0.36A 2g72B-2iipA:
36.7		 2g72B-2iipA:
36.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2iip NICOTINAMIDE
N-METHYLTRANSFERASE
(Homo
sapiens) 		4 / 7 TYR A  24
ASP A  85
ASN A  90
ASP A 142
 None
SAH  A4001 (-2.6A)
SAH  A4001 (-4.0A)
SAH  A4001 (-3.7A)
 1.06A 2g72B-2iipA:
36.7		 2g72B-2iipA:
36.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 2iip NICOTINAMIDE
N-METHYLTRANSFERASE
(Homo
sapiens) 		6 / 12 TYR A  20
GLY A  63
GLY A  65
ASP A 142
VAL A 143
TYR A  11
 SAH  A4001 (-4.6A)
SAH  A4001 (-4.0A)
SAH  A4001 (-3.0A)
SAH  A4001 (-3.7A)
SAH  A4001 (-3.7A)
SAH  A4001 (-3.7A)
 1.28A 2qe6A-2iipA:
14.4		 2qe6A-2iipA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 2iip NICOTINAMIDE
N-METHYLTRANSFERASE
(Homo
sapiens) 		4 / 6 GLU A  76
LYS A  55
PHE A  78
ILE A  81
 None
 1.14A 2w98B-2iipA:
5.9		 2w98B-2iipA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 2iip NICOTINAMIDE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 GLY A  63
GLY A  65
SER A  87
ASP A 142
VAL A 143
 SAH  A4001 (-4.0A)
SAH  A4001 (-3.0A)
SAH  A4001 (-4.7A)
SAH  A4001 (-3.7A)
SAH  A4001 (-3.7A)
 0.63A 3dlcA-2iipA:
13.9		 3dlcA-2iipA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 2iip NICOTINAMIDE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 TYR A  25
GLY A  63
GLY A  65
ASP A 142
VAL A 143
 SAH  A4001 (-4.4A)
SAH  A4001 (-4.0A)
SAH  A4001 (-3.0A)
SAH  A4001 (-3.7A)
SAH  A4001 (-3.7A)
 1.36A 3dlcA-2iipA:
13.9		 3dlcA-2iipA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 2iip NICOTINAMIDE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 TYR A  69
GLY A  63
GLY A  65
SER A  87
ASP A 142
 SAH  A4001 (-4.6A)
SAH  A4001 (-4.0A)
SAH  A4001 (-3.0A)
SAH  A4001 (-4.7A)
SAH  A4001 (-3.7A)
 0.76A 3dlcA-2iipA:
13.9		 3dlcA-2iipA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA314_0
(UNCHARACTERIZED
PROTEIN)		 2iip NICOTINAMIDE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 THR A 163
LEU A  45
VAL A  54
GLY A  53
ILE A  81
 SAH  A4001 (-4.1A)
None
None
None
None
 1.09A 3ijdA-2iipA:
undetectable		 3ijdA-2iipA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 2iip NICOTINAMIDE
N-METHYLTRANSFERASE
(Homo
sapiens) 		3 / 3 SER A   7
GLY A  -1
SER A  13
 None
 0.62A 3loqA-2iipA:
3.2		 3loqA-2iipA:
26.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2iip NICOTINAMIDE
N-METHYLTRANSFERASE
(Homo
sapiens) 		3 / 3 TYR A  20
ASP A  85
ASP A 142
 SAH  A4001 (-4.6A)
SAH  A4001 (-2.6A)
SAH  A4001 (-3.7A)
 0.28A 3ou6B-2iipA:
17.3		 3ou6B-2iipA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2iip NICOTINAMIDE
N-METHYLTRANSFERASE
(Homo
sapiens) 		3 / 3 TYR A  20
GLY A  65
ASP A  85
 SAH  A4001 (-4.6A)
SAH  A4001 (-3.0A)
SAH  A4001 (-2.6A)
 0.28A 3ou6C-2iipA:
17.2		 3ou6C-2iipA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2iip NICOTINAMIDE
N-METHYLTRANSFERASE
(Homo
sapiens) 		3 / 3 GLY A  65
ASP A  85
ASP A 142
 SAH  A4001 (-3.0A)
SAH  A4001 (-2.6A)
SAH  A4001 (-3.7A)
 0.35A 3ou7C-2iipA:
17.3		 3ou7C-2iipA:
21.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 2iip NICOTINAMIDE
N-METHYLTRANSFERASE
(Homo
sapiens) 		8 / 8 TYR A  20
LEU A 164
ASP A 197
ALA A 198
SER A 201
TYR A 204
SER A 213
TYR A 242
 SAH  A4001 (-4.6A)
SAH  A4001 (-4.1A)
None
None
None
None
None
None
 0.37A 3rodA-2iipA:
44.3		 3rodA-2iipA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 2iip NICOTINAMIDE
N-METHYLTRANSFERASE
(Homo
sapiens) 		4 / 8 TYR A  20
LEU A 164
ASP A 197
SER A 201
 SAH  A4001 (-4.6A)
SAH  A4001 (-4.1A)
None
None
 0.94A 3rodA-2iipA:
44.3		 3rodA-2iipA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 2iip NICOTINAMIDE
N-METHYLTRANSFERASE
(Homo
sapiens) 		6 / 8 TYR A  25
LEU A 164
ASP A 197
ALA A 198
SER A 201
TYR A 242
 SAH  A4001 (-4.4A)
SAH  A4001 (-4.1A)
None
None
None
None
 1.35A 3rodA-2iipA:
44.3		 3rodA-2iipA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ROD_B_NCAB302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 2iip NICOTINAMIDE
N-METHYLTRANSFERASE
(Homo
sapiens) 		9 / 9 TYR A  20
TYR A  24
LEU A 164
ASP A 197
ALA A 198
SER A 201
TYR A 204
SER A 213
TYR A 242
 SAH  A4001 (-4.6A)
None
SAH  A4001 (-4.1A)
None
None
None
None
None
None
 0.35A 3rodB-2iipA:
44.6		 3rodB-2iipA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ROD_B_NCAB302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 2iip NICOTINAMIDE
N-METHYLTRANSFERASE
(Homo
sapiens) 		7 / 9 TYR A  25
TYR A  24
LEU A 164
ASP A 197
ALA A 198
SER A 201
TYR A 242
 SAH  A4001 (-4.4A)
None
SAH  A4001 (-4.1A)
None
None
None
None
 1.50A 3rodB-2iipA:
44.6		 3rodB-2iipA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ROD_C_NCAC302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 2iip NICOTINAMIDE
N-METHYLTRANSFERASE
(Homo
sapiens) 		10 / 10 TYR A  20
TYR A  24
LEU A 164
ASP A 167
ALA A 168
ASP A 197
ALA A 198
TYR A 204
SER A 213
TYR A 242
 SAH  A4001 (-4.6A)
None
SAH  A4001 (-4.1A)
None
SAH  A4001 ( 3.9A)
None
None
None
None
None
 0.42A 3rodC-2iipA:
43.6		 3rodC-2iipA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ROD_C_NCAC302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 2iip NICOTINAMIDE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 10 TYR A  20
TYR A  24
LEU A 164
ASP A 197
SER A 201
 SAH  A4001 (-4.6A)
None
SAH  A4001 (-4.1A)
None
None
 1.00A 3rodC-2iipA:
43.6		 3rodC-2iipA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ROD_C_NCAC302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 2iip NICOTINAMIDE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 10 TYR A  24
ASP A 197
ALA A 198
TYR A 204
TYR A 242
 None
 1.36A 3rodC-2iipA:
43.6		 3rodC-2iipA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ROD_C_NCAC302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 2iip NICOTINAMIDE
N-METHYLTRANSFERASE
(Homo
sapiens) 		7 / 10 TYR A  25
TYR A  24
LEU A 164
ASP A 167
ASP A 197
ALA A 198
TYR A 242
 SAH  A4001 (-4.4A)
None
SAH  A4001 (-4.1A)
None
None
None
None
 1.42A 3rodC-2iipA:
43.6		 3rodC-2iipA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 2iip NICOTINAMIDE
N-METHYLTRANSFERASE
(Homo
sapiens) 		7 / 7 TYR A  20
LEU A 164
ASP A 167
ALA A 168
ASP A 197
TYR A 204
TYR A 242
 SAH  A4001 (-4.6A)
SAH  A4001 (-4.1A)
None
SAH  A4001 ( 3.9A)
None
None
None
 0.40A 3rodD-2iipA:
43.3		 3rodD-2iipA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 2iip NICOTINAMIDE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 7 TYR A  25
LEU A 164
ASP A 167
ASP A 197
TYR A 242
 SAH  A4001 (-4.4A)
SAH  A4001 (-4.1A)
None
None
None
 1.27A 3rodD-2iipA:
43.3		 3rodD-2iipA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 2iip NICOTINAMIDE
N-METHYLTRANSFERASE
(Homo
sapiens) 		6 / 10 ALA A 228
ARG A 181
LEU A 255
LEU A 183
ASN A 182
ILE A 195
 None
 1.33A 3wdmD-2iipA:
undetectable		 3wdmD-2iipA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2iip NICOTINAMIDE
N-METHYLTRANSFERASE
(Homo
sapiens) 		4 / 6 SER A 162
ASP A  61
ILE A 195
THR A  84
 None
 0.89A 4acbC-2iipA:
2.1		 4acbC-2iipA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 2iip NICOTINAMIDE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 GLY A  63
GLY A  65
SER A  87
ASP A 142
CYH A 165
 SAH  A4001 (-4.0A)
SAH  A4001 (-3.0A)
SAH  A4001 (-4.7A)
SAH  A4001 (-3.7A)
SAH  A4001 ( 3.8A)
 0.51A 4krhA-2iipA:
16.0		 4krhA-2iipA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 2iip NICOTINAMIDE
N-METHYLTRANSFERASE
(Homo
sapiens) 		4 / 5 GLY A 217
ARG A 218
GLU A 222
PHE A 235
 None
 1.24A 4r82A-2iipA:
undetectable
4r82B-2iipA:
undetectable		 4r82A-2iipA:
20.27
4r82B-2iipA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 2iip NICOTINAMIDE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 TYR A 176
LEU A 252
LEU A 216
LEU A 173
PHE A   5
 None
 1.37A 4rtbA-2iipA:
undetectable		 4rtbA-2iipA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 2iip NICOTINAMIDE
N-METHYLTRANSFERASE
(Homo
sapiens) 		4 / 4 ASP A  61
GLY A  65
ASP A  85
ASP A 142
 None
SAH  A4001 (-3.0A)
SAH  A4001 (-2.6A)
SAH  A4001 (-3.7A)
 0.75A 5e72A-2iipA:
13.1		 5e72A-2iipA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_H_DVAH9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2iip NICOTINAMIDE
N-METHYLTRANSFERASE
(Homo
sapiens) 		3 / 3 ALA A 179
ASN A 182
LEU A 183
 None
 0.48A 5i1oA-2iipA:
undetectable		 5i1oA-2iipA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 2iip NICOTINAMIDE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 GLY A  63
GLY A  65
ASP A 142
VAL A 143
THR A 144
 SAH  A4001 (-4.0A)
SAH  A4001 (-3.0A)
SAH  A4001 (-3.7A)
SAH  A4001 (-3.7A)
SAH  A4001 ( 4.2A)
 0.80A 5kpcB-2iipA:
11.7		 5kpcB-2iipA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 2iip NICOTINAMIDE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 GLY A  63
GLY A  65
SER A  87
ASP A 142
THR A 144
 SAH  A4001 (-4.0A)
SAH  A4001 (-3.0A)
SAH  A4001 (-4.7A)
SAH  A4001 (-3.7A)
SAH  A4001 ( 4.2A)
 0.97A 5kpcB-2iipA:
11.7		 5kpcB-2iipA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2iip NICOTINAMIDE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 10 ILE A  62
GLY A  63
GLY A  65
VAL A 138
LEU A 139
 None
SAH  A4001 (-4.0A)
SAH  A4001 (-3.0A)
None
None
 1.01A 5o96C-2iipA:
undetectable
5o96D-2iipA:
2.0		 5o96C-2iipA:
21.97
5o96D-2iipA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2iip NICOTINAMIDE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 6 LEU A 131
ARG A 132
VAL A 135
LEU A  98
VAL A  83
 None
 1.29A 5x7zA-2iipA:
undetectable		 5x7zA-2iipA:
27.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2iip NICOTINAMIDE
N-METHYLTRANSFERASE
(Homo
sapiens) 		4 / 6 ARG A 181
ALA A 228
LEU A 180
ALA A 179
 None
 1.21A 6fosB-2iipA:
undetectable		 6fosB-2iipA:
13.79