SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iir'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 2iir ACETATE KINASE
(Thermotoga
maritima) 		4 / 4 ILE A   6
MET A 134
VAL A 108
GLY A 129
 None
 1.37A 1e06B-2iirA:
undetectable		 1e06B-2iirA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2iir ACETATE KINASE
(Thermotoga
maritima) 		3 / 3 GLN A 152
ILE A 130
HIS A  89
 None
 0.73A 1fm9A-2iirA:
undetectable		 1fm9A-2iirA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC6_0
(GRAMICIDIN A)		 2iir ACETATE KINASE
(Thermotoga
maritima) 		3 / 3 ALA A 291
VAL A 301
TRP A 297
 None
 0.95A 1gmkC-2iirA:
undetectable
1gmkD-2iirA:
undetectable		 1gmkC-2iirA:
4.23
1gmkD-2iirA:
4.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2iir ACETATE KINASE
(Thermotoga
maritima) 		3 / 3 GLN A 152
ILE A 130
HIS A  89
 None
 0.69A 1k74A-2iirA:
undetectable		 1k74A-2iirA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2iir ACETATE KINASE
(Thermotoga
maritima) 		4 / 5 LEU A  56
GLY A 129
ALA A  31
ILE A  34
 None
 0.85A 2aohB-2iirA:
undetectable		 2aohB-2iirA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)		 2iir ACETATE KINASE
(Thermotoga
maritima) 		5 / 11 VAL A  42
LEU A  41
ILE A  34
SER A  12
SER A   8
 None
 1.31A 3bjwB-2iirA:
undetectable		 3bjwB-2iirA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 2iir ACETATE KINASE
(Thermotoga
maritima) 		5 / 11 VAL A  42
LEU A  41
ILE A  34
SER A  12
SER A   8
 None
 1.31A 3bjwH-2iirA:
undetectable		 3bjwH-2iirA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)		 2iir ACETATE KINASE
(Thermotoga
maritima) 		4 / 6 ILE A 390
TYR A 185
MET A  20
ILE A  18
 None
 1.05A 3eteA-2iirA:
2.1
3eteE-2iirA:
2.0		 3eteA-2iirA:
23.20
3eteE-2iirA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)		 2iir ACETATE KINASE
(Thermotoga
maritima) 		4 / 5 ILE A 390
TYR A 185
MET A  20
ILE A  18
 None
 1.07A 3eteB-2iirA:
2.0
3eteC-2iirA:
undetectable		 3eteB-2iirA:
23.20
3eteC-2iirA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)		 2iir ACETATE KINASE
(Thermotoga
maritima) 		4 / 7 MET A  20
ILE A  18
ILE A 390
TYR A 185
 None
 1.04A 3eteD-2iirA:
undetectable
3eteF-2iirA:
2.1		 3eteD-2iirA:
23.20
3eteF-2iirA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 2iir ACETATE KINASE
(Thermotoga
maritima) 		4 / 8 VAL A 214
VAL A 343
TYR A 312
ILE A 313
 None
 1.01A 3remA-2iirA:
undetectable		 3remA-2iirA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 2iir ACETATE KINASE
(Thermotoga
maritima) 		4 / 8 VAL A 214
VAL A 343
TYR A 312
ILE A 313
 None
 1.04A 3remB-2iirA:
undetectable		 3remB-2iirA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2iir ACETATE KINASE
(Thermotoga
maritima) 		6 / 11 ALA A 212
ASN A 335
GLY A 331
ALA A 330
THR A 384
VAL A 186
 None
 1.27A 3rukD-2iirA:
undetectable		 3rukD-2iirA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2iir ACETATE KINASE
(Thermotoga
maritima) 		5 / 11 ALA A 212
ASN A 335
GLY A 331
ALA A 330
VAL A 327
 None
 1.02A 3rukD-2iirA:
undetectable		 3rukD-2iirA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2iir ACETATE KINASE
(Thermotoga
maritima) 		5 / 11 ASN A 335
GLY A 331
ALA A 330
THR A 329
VAL A 327
 None
 1.21A 3rukD-2iirA:
undetectable		 3rukD-2iirA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)		 2iir ACETATE KINASE
(Thermotoga
maritima) 		5 / 11 ILE A 309
ILE A 313
GLY A 314
PHE A 328
VAL A 379
 None
 1.04A 4ac9B-2iirA:
undetectable
4ac9C-2iirA:
2.3		 4ac9B-2iirA:
23.61
4ac9C-2iirA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2iir ACETATE KINASE
(Thermotoga
maritima) 		4 / 5 GLY A  95
GLY A  94
ASN A 123
GLU A  96
 None
 1.15A 4fglC-2iirA:
undetectable		 4fglC-2iirA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2iir ACETATE KINASE
(Thermotoga
maritima) 		4 / 5 THR A 384
THR A 329
THR A 225
HIS A 151
 None
 1.18A 4pgfB-2iirA:
undetectable		 4pgfB-2iirA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 2iir ACETATE KINASE
(Thermotoga
maritima) 		4 / 5 HIS A  59
ILE A  34
SER A   8
ALA A  31
 None
 1.03A 5msdA-2iirA:
undetectable		 5msdA-2iirA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2iir ACETATE KINASE
(Thermotoga
maritima) 		3 / 3 GLN A 152
ILE A 130
HIS A  89
 None
 0.70A 5z12B-2iirA:
undetectable		 5z12B-2iirA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)		 2iir ACETATE KINASE
(Thermotoga
maritima) 		4 / 5 THR A 329
THR A 225
HIS A 151
GLY A 211
 None
 1.12A 6gbnC-2iirA:
2.3		 6gbnC-2iirA:
21.46