SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iiz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 2iiz MELANIN BIOSYNTHESIS
PROTEIN TYRA,
PUTATIVE
(Shewanella
oneidensis) 		4 / 5 GLN A 308
PHE A 305
PHE A 174
TRP A  70
 None
 1.32A 2qmzA-2iizA:
undetectable
2qmzB-2iizA:
undetectable		 2qmzA-2iizA:
21.56
2qmzB-2iizA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 2iiz MELANIN BIOSYNTHESIS
PROTEIN TYRA,
PUTATIVE
(Shewanella
oneidensis) 		3 / 3 SER A 237
GLU A 213
ASP A 218
 None
HEM  A 400 ( 4.7A)
None
 0.82A 2zulA-2iizA:
undetectable		 2zulA-2iizA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2iiz MELANIN BIOSYNTHESIS
PROTEIN TYRA,
PUTATIVE
(Shewanella
oneidensis) 		5 / 12 GLN A 243
PHE A 298
ALA A  64
GLY A  12
LEU A 106
 None
 1.35A 3aodC-2iizA:
2.1		 3aodC-2iizA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 2iiz MELANIN BIOSYNTHESIS
PROTEIN TYRA,
PUTATIVE
(Shewanella
oneidensis) 		3 / 3 SER A 237
GLU A 213
ASP A 218
 None
HEM  A 400 ( 4.7A)
None
 0.83A 3dmhA-2iizA:
undetectable		 3dmhA-2iizA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2iiz MELANIN BIOSYNTHESIS
PROTEIN TYRA,
PUTATIVE
(Shewanella
oneidensis) 		3 / 3 TYR A 179
ASP A 265
ASP A 232
 None
 0.78A 3ou6B-2iizA:
undetectable		 3ou6B-2iizA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 2iiz MELANIN BIOSYNTHESIS
PROTEIN TYRA,
PUTATIVE
(Shewanella
oneidensis) 		4 / 7 ASN A  68
ALA A  67
PRO A  84
ALA A  97
 None
 0.85A 3twpA-2iizA:
undetectable		 3twpA-2iizA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 2iiz MELANIN BIOSYNTHESIS
PROTEIN TYRA,
PUTATIVE
(Shewanella
oneidensis) 		4 / 7 ASN A  68
ALA A  67
PRO A  84
ALA A  97
 None
 0.86A 3twpB-2iizA:
undetectable		 3twpB-2iizA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 2iiz MELANIN BIOSYNTHESIS
PROTEIN TYRA,
PUTATIVE
(Shewanella
oneidensis) 		4 / 7 ASN A  68
ALA A  67
PRO A  84
ALA A  97
 None
 0.86A 3twpC-2iizA:
undetectable		 3twpC-2iizA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 2iiz MELANIN BIOSYNTHESIS
PROTEIN TYRA,
PUTATIVE
(Shewanella
oneidensis) 		4 / 5 ASN A  68
ALA A  67
PRO A  84
ALA A  97
 None
 0.84A 3twpD-2iizA:
undetectable		 3twpD-2iizA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_1
(ADENOSINE KINASE,
PUTATIVE)		 2iiz MELANIN BIOSYNTHESIS
PROTEIN TYRA,
PUTATIVE
(Shewanella
oneidensis) 		5 / 12 ILE A 240
VAL A 228
LEU A 271
GLY A 152
ASP A 151
 None
HEM  A 400 (-4.4A)
HEM  A 400 ( 4.5A)
HEM  A 400 (-3.4A)
HEM  A 400 (-4.1A)
 1.08A 3uq6B-2iizA:
undetectable		 3uq6B-2iizA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2iiz MELANIN BIOSYNTHESIS
PROTEIN TYRA,
PUTATIVE
(Shewanella
oneidensis) 		4 / 5 ILE A  98
ASP A 101
GLU A 133
VAL A 182
 None
 1.17A 4nkxC-2iizA:
undetectable		 4nkxC-2iizA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		 2iiz MELANIN BIOSYNTHESIS
PROTEIN TYRA,
PUTATIVE
(Shewanella
oneidensis) 		4 / 7 TYR A 247
TYR A 111
GLU A 135
PHE A 138
 None
 1.11A 5aclA-2iizA:
undetectable		 5aclA-2iizA:
16.01