SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ija'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 2ija ARYLAMINE
N-ACETYLTRANSFERASE
1
(Homo
sapiens) 		4 / 6 GLN A 130
ASP A 122
HIS A 107
CYH A  68
 None
None
ACM  A 301 (-4.0A)
ACM  A 301 (-1.7A)
 1.47A 1ekjG-2ijaA:
undetectable
1ekjH-2ijaA:
undetectable		 1ekjG-2ijaA:
20.13
1ekjH-2ijaA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 2ija ARYLAMINE
N-ACETYLTRANSFERASE
1
(Homo
sapiens) 		4 / 6 GLN A 130
ASP A 122
VAL A  71
HIS A 107
 None
None
None
ACM  A 301 (-4.0A)
 1.23A 1ekjG-2ijaA:
undetectable
1ekjH-2ijaA:
undetectable		 1ekjG-2ijaA:
20.13
1ekjH-2ijaA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2ija ARYLAMINE
N-ACETYLTRANSFERASE
1
(Homo
sapiens) 		5 / 12 TYR A 190
LEU A 135
ILE A 189
SER A 184
SER A 128
 None
 1.45A 1xotB-2ijaA:
undetectable		 1xotB-2ijaA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 2ija ARYLAMINE
N-ACETYLTRANSFERASE
1
(Homo
sapiens) 		5 / 11 LEU A 275
LEU A 279
LEU A 234
LEU A 267
ARG A  64
 None
 0.99A 2ceoA-2ijaA:
undetectable		 2ceoA-2ijaA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 2ija ARYLAMINE
N-ACETYLTRANSFERASE
1
(Homo
sapiens) 		5 / 10 LEU A 275
LEU A 279
LEU A 234
LEU A 267
ARG A  64
 None
 1.10A 2xn6A-2ijaA:
undetectable
2xn6B-2ijaA:
undetectable		 2xn6A-2ijaA:
21.07
2xn6B-2ijaA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 2ija ARYLAMINE
N-ACETYLTRANSFERASE
1
(Homo
sapiens) 		4 / 6 ASP A 251
ILE A 253
LEU A 181
TYR A 129
 None
 1.07A 2ya7A-2ijaA:
undetectable		 2ya7A-2ijaA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 2ija ARYLAMINE
N-ACETYLTRANSFERASE
1
(Homo
sapiens) 		4 / 6 ASP A 251
ILE A 253
LEU A 181
TYR A 129
 None
 1.06A 2ya7B-2ijaA:
undetectable		 2ya7B-2ijaA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 2ija ARYLAMINE
N-ACETYLTRANSFERASE
1
(Homo
sapiens) 		4 / 6 ASP A 251
ILE A 253
LEU A 181
TYR A 129
 None
 1.06A 2ya7D-2ijaA:
undetectable		 2ya7D-2ijaA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ija ARYLAMINE
N-ACETYLTRANSFERASE
1
(Homo
sapiens) 		4 / 7 LEU A  69
ARG A 197
SER A 215
GLY A 104
 ACM  A 301 ( 4.8A)
None
None
None
 0.98A 3hcrB-2ijaA:
undetectable		 3hcrB-2ijaA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_A_ACRA730_1
(ALPHA-AMYLASE, SUSG)		 2ija ARYLAMINE
N-ACETYLTRANSFERASE
1
(Homo
sapiens) 		4 / 5 ARG A 151
TYR A 160
LYS A 188
ASP A 162
 None
 1.03A 3k8mA-2ijaA:
0.0		 3k8mA-2ijaA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB830_1
(ALPHA-AMYLASE, SUSG)		 2ija ARYLAMINE
N-ACETYLTRANSFERASE
1
(Homo
sapiens) 		4 / 5 ARG A 151
TYR A 160
LYS A 188
ASP A 162
 None
 0.96A 3k8mB-2ijaA:
0.0		 3k8mB-2ijaA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 2ija ARYLAMINE
N-ACETYLTRANSFERASE
1
(Homo
sapiens) 		4 / 6 PHE A  37
CYH A  68
VAL A  93
PHE A 217
 None
ACM  A 301 (-1.7A)
None
ACM  A 301 (-4.2A)
 0.70A 3ltwA-2ijaA:
32.5		 3ltwA-2ijaA:
29.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 2ija ARYLAMINE
N-ACETYLTRANSFERASE
1
(Homo
sapiens) 		4 / 8 HIS A  43
SER A 219
ASP A 179
LEU A 180
 None
 1.05A 3n2oC-2ijaA:
undetectable
3n2oD-2ijaA:
undetectable		 3n2oC-2ijaA:
19.44
3n2oD-2ijaA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 2ija ARYLAMINE
N-ACETYLTRANSFERASE
1
(Homo
sapiens) 		4 / 7 ILE A  32
GLN A 130
GLY A 124
VAL A  71
 None
 1.01A 4a3uB-2ijaA:
undetectable		 4a3uB-2ijaA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2ija ARYLAMINE
N-ACETYLTRANSFERASE
1
(Homo
sapiens) 		4 / 7 TYR A  94
VAL A  93
ILE A 106
GLU A 182
 UNX  A 502 (-4.3A)
None
None
None
 1.07A 4a97E-2ijaA:
undetectable		 4a97E-2ijaA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2ija ARYLAMINE
N-ACETYLTRANSFERASE
1
(Homo
sapiens) 		4 / 7 TYR A  94
VAL A  93
ILE A 106
GLU A 182
 UNX  A 502 (-4.3A)
None
None
None
 1.08A 4a97H-2ijaA:
undetectable		 4a97H-2ijaA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2ija ARYLAMINE
N-ACETYLTRANSFERASE
1
(Homo
sapiens) 		4 / 8 TYR A  94
VAL A  93
ILE A 106
GLU A 182
 UNX  A 502 (-4.3A)
None
None
None
 1.04A 4a97I-2ijaA:
undetectable		 4a97I-2ijaA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2ija ARYLAMINE
N-ACETYLTRANSFERASE
1
(Homo
sapiens) 		5 / 12 LEU A 234
LEU A  40
LEU A 258
SER A 259
VAL A 266
 None
 1.16A 5twjC-2ijaA:
undetectable		 5twjC-2ijaA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 2ija ARYLAMINE
N-ACETYLTRANSFERASE
1
(Homo
sapiens) 		4 / 8 LEU A 152
LEU A 137
GLY A  90
ARG A 197
 None
 0.93A 6ce2A-2ijaA:
undetectable		 6ce2A-2ijaA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 2ija ARYLAMINE
N-ACETYLTRANSFERASE
1
(Homo
sapiens) 		4 / 8 VAL A  59
TRP A  67
HIS A  73
ASN A  72
 None
ACM  A 301 (-4.7A)
None
None
 1.17A 6gneB-2ijaA:
undetectable		 6gneB-2ijaA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2ija ARYLAMINE
N-ACETYLTRANSFERASE
1
(Homo
sapiens) 		4 / 5 ARG A 197
MET A  88
THR A  87
LEU A 110
 None
 1.36A 6nknW-2ijaA:
undetectable		 6nknW-2ijaA:
12.28