SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ije'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)		 2ije GUANINE
NUCLEOTIDE-RELEASING
PROTEIN
(Mus
musculus) 		5 / 10 ALA S1117
GLU S1120
LEU S1035
LEU S1038
ILE S1227
 None
 1.46A 1a52B-2ijeS:
undetectable		 1a52B-2ijeS:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 2ije GUANINE
NUCLEOTIDE-RELEASING
PROTEIN
(Mus
musculus) 		3 / 3 GLU S1216
ILE S1213
ARG S1160
 None
 0.59A 1cd2A-2ijeS:
undetectable		 1cd2A-2ijeS:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_A_ESTA600_1
(ESTROGEN RECEPTOR)		 2ije GUANINE
NUCLEOTIDE-RELEASING
PROTEIN
(Mus
musculus) 		5 / 9 ALA S1117
GLU S1120
LEU S1035
LEU S1038
ILE S1227
 None
 1.46A 1ereA-2ijeS:
undetectable		 1ereA-2ijeS:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_B_ESTB600_1
(ESTROGEN RECEPTOR)		 2ije GUANINE
NUCLEOTIDE-RELEASING
PROTEIN
(Mus
musculus) 		5 / 9 ALA S1117
GLU S1120
LEU S1035
LEU S1038
ILE S1227
 None
 1.48A 1ereB-2ijeS:
undetectable		 1ereB-2ijeS:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_C_ESTC600_1
(ESTROGEN RECEPTOR)		 2ije GUANINE
NUCLEOTIDE-RELEASING
PROTEIN
(Mus
musculus) 		5 / 9 ALA S1117
GLU S1120
LEU S1035
LEU S1038
ILE S1227
 None
 1.45A 1ereC-2ijeS:
undetectable		 1ereC-2ijeS:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_D_ESTD600_1
(ESTROGEN RECEPTOR)		 2ije GUANINE
NUCLEOTIDE-RELEASING
PROTEIN
(Mus
musculus) 		5 / 9 ALA S1117
GLU S1120
LEU S1035
LEU S1038
ILE S1227
 None
 1.47A 1ereD-2ijeS:
undetectable		 1ereD-2ijeS:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 2ije GUANINE
NUCLEOTIDE-RELEASING
PROTEIN
(Mus
musculus) 		3 / 3 SER S1124
GLU S1085
ASP S1239
 None
 0.77A 2avdB-2ijeS:
undetectable		 2avdB-2ijeS:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2ije GUANINE
NUCLEOTIDE-RELEASING
PROTEIN
(Mus
musculus) 		4 / 8 SER S1124
ARG S1127
GLU S1085
ILE S1086
 None
 1.00A 4d33A-2ijeS:
undetectable		 4d33A-2ijeS:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2ije GUANINE
NUCLEOTIDE-RELEASING
PROTEIN
(Mus
musculus) 		4 / 7 SER S1124
ARG S1127
GLU S1085
ILE S1086
 None
 0.99A 4d33B-2ijeS:
undetectable		 4d33B-2ijeS:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2ije GUANINE
NUCLEOTIDE-RELEASING
PROTEIN
(Mus
musculus) 		4 / 8 SER S1124
ARG S1127
GLU S1085
ILE S1086
 None
 0.95A 4d39A-2ijeS:
undetectable		 4d39A-2ijeS:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2ije GUANINE
NUCLEOTIDE-RELEASING
PROTEIN
(Mus
musculus) 		4 / 7 SER S1124
ARG S1127
GLU S1085
ILE S1086
 None
 0.93A 4d39B-2ijeS:
undetectable		 4d39B-2ijeS:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2ije GUANINE
NUCLEOTIDE-RELEASING
PROTEIN
(Mus
musculus) 		4 / 8 ASP S1039
ASN S1114
CYH S1175
GLU S1120
 None
 1.21A 4feuF-2ijeS:
undetectable		 4feuF-2ijeS:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2ije GUANINE
NUCLEOTIDE-RELEASING
PROTEIN
(Mus
musculus) 		4 / 8 ASP S1039
ASN S1114
CYH S1175
GLU S1120
 None
 1.16A 4fewD-2ijeS:
undetectable		 4fewD-2ijeS:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2ije GUANINE
NUCLEOTIDE-RELEASING
PROTEIN
(Mus
musculus) 		4 / 8 ASP S1039
ASN S1114
CYH S1175
GLU S1120
 None
 1.15A 4fewF-2ijeS:
undetectable		 4fewF-2ijeS:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2ije GUANINE
NUCLEOTIDE-RELEASING
PROTEIN
(Mus
musculus) 		4 / 8 ASP S1039
ASN S1114
CYH S1175
GLU S1120
 None
 1.15A 4gkhB-2ijeS:
undetectable		 4gkhB-2ijeS:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2ije GUANINE
NUCLEOTIDE-RELEASING
PROTEIN
(Mus
musculus) 		4 / 8 ASP S1039
ASN S1114
CYH S1175
GLU S1120
 None
 1.16A 4gkiA-2ijeS:
undetectable		 4gkiA-2ijeS:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2ije GUANINE
NUCLEOTIDE-RELEASING
PROTEIN
(Mus
musculus) 		4 / 8 ASP S1039
ASN S1114
CYH S1175
GLU S1120
 None
 1.18A 4gkiC-2ijeS:
undetectable		 4gkiC-2ijeS:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA610_0
(SERUM ALBUMIN)		 2ije GUANINE
NUCLEOTIDE-RELEASING
PROTEIN
(Mus
musculus) 		3 / 3 VAL S1140
SER S1141
THR S1144
 None
 0.25A 4luhA-2ijeS:
undetectable		 4luhA-2ijeS:
18.15