SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ijx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2ijx DNA POLYMERASE
SLIDING CLAMP A
(Sulfolobus
solfataricus) 		5 / 12 ILE A  15
ALA A  25
LEU A  21
LEU A 207
ILE A  14
 None
 1.02A 1dhiA-2ijxA:
undetectable		 1dhiA-2ijxA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2ijx DNA POLYMERASE
SLIDING CLAMP A
(Sulfolobus
solfataricus) 		5 / 11 ILE A  15
ALA A  25
LEU A  21
LEU A 207
ILE A  14
 None
 1.05A 1dhiB-2ijxA:
undetectable		 1dhiB-2ijxA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2ijx DNA POLYMERASE
SLIDING CLAMP A
(Sulfolobus
solfataricus) 		5 / 12 ILE A  15
ALA A  25
LEU A  21
LEU A 207
ILE A  14
 None
 1.07A 1draB-2ijxA:
undetectable		 1draB-2ijxA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2ijx DNA POLYMERASE
SLIDING CLAMP A
(Sulfolobus
solfataricus) 		5 / 12 ILE A  15
ALA A  25
LEU A  21
LEU A 207
ILE A  14
 None
 1.05A 1ra3A-2ijxA:
undetectable		 1ra3A-2ijxA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 2ijx DNA POLYMERASE
SLIDING CLAMP A
(Sulfolobus
solfataricus) 		4 / 5 LEU A  18
ILE A  47
LEU A  46
SER A  45
 None
 0.78A 2byoA-2ijxA:
undetectable		 2byoA-2ijxA:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 2ijx DNA POLYMERASE
SLIDING CLAMP A
(Sulfolobus
solfataricus) 		5 / 12 ILE A  15
ALA A  25
LEU A  21
LEU A 207
ILE A  14
 None
 1.07A 2drcB-2ijxA:
undetectable		 2drcB-2ijxA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAX_A_CAMA422_0
(CYTOCHROME P450-CAM)		 2ijx DNA POLYMERASE
SLIDING CLAMP A
(Sulfolobus
solfataricus) 		4 / 7 LEU A 201
VAL A 204
THR A 208
VAL A 214
 None
 0.87A 2zaxA-2ijxA:
undetectable		 2zaxA-2ijxA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 2ijx DNA POLYMERASE
SLIDING CLAMP A
(Sulfolobus
solfataricus) 		3 / 3 PHE A  67
ASN A 113
PHE A  65
 None
 0.94A 2zbuD-2ijxA:
undetectable		 2zbuD-2ijxA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 2ijx DNA POLYMERASE
SLIDING CLAMP A
(Sulfolobus
solfataricus) 		4 / 6 ILE A  89
GLU A  88
ILE A  98
ASP A  60
 None
 0.99A 3a7eA-2ijxA:
undetectable		 3a7eA-2ijxA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2ijx DNA POLYMERASE
SLIDING CLAMP A
(Sulfolobus
solfataricus) 		5 / 12 TYR A 196
ILE A 164
GLY A 219
PHE A 128
LEU A 201
 None
 1.15A 3em0B-2ijxA:
1.1		 3em0B-2ijxA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA702_1
(CARBONIC ANHYDRASE 2)		 2ijx DNA POLYMERASE
SLIDING CLAMP A
(Sulfolobus
solfataricus) 		4 / 7 VAL A  61
TYR A  59
LYS A  28
GLU A  35
 None
 1.25A 3hs4A-2ijxA:
undetectable		 3hs4A-2ijxA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 2ijx DNA POLYMERASE
SLIDING CLAMP A
(Sulfolobus
solfataricus) 		4 / 8 ILE A 134
SER A 195
GLU A 156
VAL A 153
 None
 0.74A 3ua5A-2ijxA:
undetectable		 3ua5A-2ijxA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 2ijx DNA POLYMERASE
SLIDING CLAMP A
(Sulfolobus
solfataricus) 		3 / 3 HIS A  43
VAL A 204
LEU A  21
 None
 0.71A 4m2vA-2ijxA:
undetectable		 4m2vA-2ijxA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2ijx DNA POLYMERASE
SLIDING CLAMP A
(Sulfolobus
solfataricus) 		5 / 11 ILE A  15
ALA A  25
LEU A  21
LEU A 207
ILE A  14
 None
 1.05A 4p66A-2ijxA:
undetectable		 4p66A-2ijxA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 2ijx DNA POLYMERASE
SLIDING CLAMP A
(Sulfolobus
solfataricus) 		3 / 3 GLU A 167
LYS A 165
ASN A 152
 None
 1.03A 4y1dA-2ijxA:
undetectable
4y1dD-2ijxA:
undetectable		 4y1dA-2ijxA:
19.68
4y1dD-2ijxA:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 2ijx DNA POLYMERASE
SLIDING CLAMP A
(Sulfolobus
solfataricus) 		3 / 3 SER A 217
GLU A 123
GLU A  35
 None
EDO  A 609 ( 4.0A)
None
 0.77A 4ymgB-2ijxA:
undetectable		 4ymgB-2ijxA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_B_TESB502_1
(-)		 2ijx DNA POLYMERASE
SLIDING CLAMP A
(Sulfolobus
solfataricus) 		5 / 12 LEU A 224
VAL A 153
ILE A 134
ALA A 142
LEU A 163
 None
 1.09A 5og9B-2ijxA:
undetectable		 5og9B-2ijxA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA303_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2ijx DNA POLYMERASE
SLIDING CLAMP A
(Sulfolobus
solfataricus) 		3 / 3 GLU A  58
TYR A  59
ARG A  53
 None
 0.86A 5uunA-2ijxA:
undetectable		 5uunA-2ijxA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2ijx DNA POLYMERASE
SLIDING CLAMP A
(Sulfolobus
solfataricus) 		3 / 3 GLU A  58
TYR A  59
ARG A  53
 None
 0.79A 5uunB-2ijxA:
undetectable		 5uunB-2ijxA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 2ijx DNA POLYMERASE
SLIDING CLAMP A
(Sulfolobus
solfataricus) 		5 / 12 PHE A  67
LEU A  74
VAL A   8
VAL A   3
SER A  91
 None
 1.28A 5v1tA-2ijxA:
undetectable		 5v1tA-2ijxA:
20.91