SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ijz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4003_1
(SERUM ALBUMIN)		 2ijz PROBABLE M18-FAMILY
AMINOPEPTIDASE 2
(Pseudomonas
aeruginosa) 		4 / 6 PHE A 294
VAL A 388
GLY A 387
LEU A  78
 None
 0.81A 1e7bB-2ijzA:
undetectable		 1e7bB-2ijzA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 2ijz PROBABLE M18-FAMILY
AMINOPEPTIDASE 2
(Pseudomonas
aeruginosa) 		4 / 7 GLU A 246
THR A 390
VAL A 391
ALA A  81
 None
 1.09A 1fo4B-2ijzA:
undetectable		 1fo4B-2ijzA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 2ijz PROBABLE M18-FAMILY
AMINOPEPTIDASE 2
(Pseudomonas
aeruginosa) 		5 / 11 ALA A 421
ARG A  77
VAL A 391
LEU A 395
ALA A 306
 None
 1.21A 1n4hA-2ijzA:
undetectable		 1n4hA-2ijzA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 2ijz PROBABLE M18-FAMILY
AMINOPEPTIDASE 2
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 233
GLY A 408
GLY A 244
LEU A 245
LEU A 248
 None
 0.64A 2hw2A-2ijzA:
undetectable		 2hw2A-2ijzA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 2ijz PROBABLE M18-FAMILY
AMINOPEPTIDASE 2
(Pseudomonas
aeruginosa) 		4 / 8 GLY A 253
SER A 425
ALA A 424
CYH A 257
 None
 0.74A 2vh3B-2ijzA:
undetectable		 2vh3B-2ijzA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 2ijz PROBABLE M18-FAMILY
AMINOPEPTIDASE 2
(Pseudomonas
aeruginosa) 		5 / 12 ILE A  64
VAL A 386
VAL A 388
PRO A 380
PHE A 279
 None
 1.09A 2ygpA-2ijzA:
undetectable		 2ygpA-2ijzA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_A_1FLA502_1
(TRANSTHYRETIN)		 2ijz PROBABLE M18-FAMILY
AMINOPEPTIDASE 2
(Pseudomonas
aeruginosa) 		4 / 7 LEU A 395
ALA A 306
SER A 240
VAL A  79
 None
 0.95A 3d2tA-2ijzA:
undetectable		 3d2tA-2ijzA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 2ijz PROBABLE M18-FAMILY
AMINOPEPTIDASE 2
(Pseudomonas
aeruginosa) 		5 / 12 HIS A  82
GLY A 111
GLY A 110
LEU A  88
ASP A 236
 None
 0.99A 3i5uA-2ijzA:
undetectable		 3i5uA-2ijzA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 2ijz PROBABLE M18-FAMILY
AMINOPEPTIDASE 2
(Pseudomonas
aeruginosa) 		5 / 12 HIS A  82
GLY A 111
GLY A 110
LEU A  88
ASP A 236
 None
 0.97A 3i5uB-2ijzA:
undetectable		 3i5uB-2ijzA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 2ijz PROBABLE M18-FAMILY
AMINOPEPTIDASE 2
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 341
ILE A 378
THR A 262
 None
 0.69A 3ia4D-2ijzA:
undetectable		 3ia4D-2ijzA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2ijz PROBABLE M18-FAMILY
AMINOPEPTIDASE 2
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 230
LEU A  13
ASP A 411
LEU A 328
GLY A 408
 None
 1.13A 3k2hB-2ijzA:
undetectable		 3k2hB-2ijzA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 2ijz PROBABLE M18-FAMILY
AMINOPEPTIDASE 2
(Pseudomonas
aeruginosa) 		3 / 3 GLU A 211
GLU A  95
ASN A  93
 None
 0.83A 3lp9B-2ijzA:
undetectable
3lp9D-2ijzA:
undetectable		 3lp9B-2ijzA:
20.05
3lp9D-2ijzA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)		 2ijz PROBABLE M18-FAMILY
AMINOPEPTIDASE 2
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 238
HIS A 401
MET A 400
THR A 397
 None
 1.33A 3thrB-2ijzA:
undetectable		 3thrB-2ijzA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 2ijz PROBABLE M18-FAMILY
AMINOPEPTIDASE 2
(Pseudomonas
aeruginosa) 		4 / 7 ALA A 383
ARG A 389
ALA A 343
ARG A 341
 None
 1.11A 3twpA-2ijzA:
undetectable		 3twpA-2ijzA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 2ijz PROBABLE M18-FAMILY
AMINOPEPTIDASE 2
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 230
LEU A  13
ASP A 411
LEU A 328
GLY A 408
 None
 1.06A 4foxA-2ijzA:
undetectable		 4foxA-2ijzA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 2ijz PROBABLE M18-FAMILY
AMINOPEPTIDASE 2
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 230
LEU A  13
ASP A 411
LEU A 328
GLY A 408
 None
 1.08A 4foxB-2ijzA:
undetectable		 4foxB-2ijzA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 2ijz PROBABLE M18-FAMILY
AMINOPEPTIDASE 2
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 230
LEU A  13
ASP A 411
LEU A 328
GLY A 408
 None
 1.12A 4foxG-2ijzA:
undetectable		 4foxG-2ijzA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2ijz PROBABLE M18-FAMILY
AMINOPEPTIDASE 2
(Pseudomonas
aeruginosa) 		6 / 12 LEU A 355
GLY A 420
ALA A 306
ILE A 393
VAL A 304
VAL A  79
 None
 1.18A 4nkxB-2ijzA:
undetectable		 4nkxB-2ijzA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 2ijz PROBABLE M18-FAMILY
AMINOPEPTIDASE 2
(Pseudomonas
aeruginosa) 		5 / 11 ILE A 230
LEU A  13
ASP A 411
LEU A 328
GLY A 408
 None
 1.12A 5fctA-2ijzA:
undetectable		 5fctA-2ijzA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 2ijz PROBABLE M18-FAMILY
AMINOPEPTIDASE 2
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 230
LEU A  13
ASP A 411
LEU A 328
GLY A 408
 None
 1.09A 5j7wC-2ijzA:
undetectable		 5j7wC-2ijzA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2ijz PROBABLE M18-FAMILY
AMINOPEPTIDASE 2
(Pseudomonas
aeruginosa) 		4 / 7 VAL A  90
PRO A 175
ILE A 176
THR A 217
 None
 1.06A 5vkqA-2ijzA:
undetectable
5vkqD-2ijzA:
undetectable		 5vkqA-2ijzA:
14.17
5vkqD-2ijzA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 2ijz PROBABLE M18-FAMILY
AMINOPEPTIDASE 2
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 306
PHE A 352
LEU A 415
GLY A 420
ALA A 421
 None
 0.91A 5x23A-2ijzA:
undetectable		 5x23A-2ijzA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2ijz PROBABLE M18-FAMILY
AMINOPEPTIDASE 2
(Pseudomonas
aeruginosa) 		5 / 9 PRO A 175
GLY A 105
SER A 123
LEU A 102
LEU A 208
 None
 1.42A 6dm0A-2ijzA:
1.3
6dm0D-2ijzA:
undetectable		 6dm0A-2ijzA:
11.85
6dm0D-2ijzA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 2ijz PROBABLE M18-FAMILY
AMINOPEPTIDASE 2
(Pseudomonas
aeruginosa) 		5 / 10 ILE A 230
LEU A  13
ASP A 411
LEU A 328
GLY A 408
 None
 1.18A 6r2eB-2ijzA:
undetectable		 6r2eB-2ijzA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 2ijz PROBABLE M18-FAMILY
AMINOPEPTIDASE 2
(Pseudomonas
aeruginosa) 		5 / 10 PHE A 229
ILE A 230
LEU A  13
ASP A 411
GLY A 408
 None
 1.45A 6r2eB-2ijzA:
undetectable		 6r2eB-2ijzA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 2ijz PROBABLE M18-FAMILY
AMINOPEPTIDASE 2
(Pseudomonas
aeruginosa) 		5 / 10 ILE A 230
LEU A  13
ASP A 411
LEU A 328
GLY A 408
 None
 1.14A 6r2eC-2ijzA:
undetectable		 6r2eC-2ijzA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 2ijz PROBABLE M18-FAMILY
AMINOPEPTIDASE 2
(Pseudomonas
aeruginosa) 		5 / 10 PHE A 229
ILE A 230
LEU A  13
ASP A 411
GLY A 408
 None
 1.43A 6r2eC-2ijzA:
undetectable		 6r2eC-2ijzA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 2ijz PROBABLE M18-FAMILY
AMINOPEPTIDASE 2
(Pseudomonas
aeruginosa) 		5 / 10 ILE A 230
LEU A  13
ASP A 411
LEU A 328
GLY A 408
 None
 1.12A 6r2eD-2ijzA:
undetectable		 6r2eD-2ijzA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 2ijz PROBABLE M18-FAMILY
AMINOPEPTIDASE 2
(Pseudomonas
aeruginosa) 		5 / 10 PHE A 229
ILE A 230
LEU A  13
ASP A 411
GLY A 408
 None
 1.42A 6r2eD-2ijzA:
undetectable		 6r2eD-2ijzA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 2ijz PROBABLE M18-FAMILY
AMINOPEPTIDASE 2
(Pseudomonas
aeruginosa) 		5 / 11 ILE A 230
LEU A  13
ASP A 411
LEU A 328
GLY A 408
 None
 1.13A 6r2eF-2ijzA:
undetectable		 6r2eF-2ijzA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 2ijz PROBABLE M18-FAMILY
AMINOPEPTIDASE 2
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 230
LEU A  13
ASP A 411
LEU A 328
GLY A 408
 None
 1.23A 6r2eH-2ijzA:
undetectable		 6r2eH-2ijzA:
21.28