SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ik8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2ik8 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(I),
ALPHA-1 SUBUNIT
(Homo
sapiens) 		4 / 8 SER A  44
SER A  47
GLY A 203
GLY A  40
 GDP  A 401 (-3.6A)
MG  A 356 ( 1.9A)
ALF  A 355 (-3.3A)
None
 0.72A 1f5lA-2ik8A:
undetectable		 1f5lA-2ik8A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 2ik8 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(I),
ALPHA-1 SUBUNIT
(Homo
sapiens) 		4 / 7 GLN A 172
ASP A 173
LEU A 159
SER A 151
 None
None
None
GDP  A 401 (-3.6A)
 0.95A 1ig3A-2ik8A:
undetectable
1ig3B-2ik8A:
2.8		 1ig3A-2ik8A:
20.72
1ig3B-2ik8A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2ik8 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(I),
ALPHA-1 SUBUNIT
(Homo
sapiens) 		4 / 7 PHE A 336
PHE A 267
VAL A 225
SER A  44
 None
None
None
GDP  A 401 (-3.6A)
 1.05A 1wrlA-2ik8A:
undetectable
1wrlB-2ik8A:
undetectable		 1wrlA-2ik8A:
14.72
1wrlB-2ik8A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1
(SERUM ALBUMIN)		 2ik8 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(I),
ALPHA-1 SUBUNIT
(Homo
sapiens) 		4 / 5 LEU A 107
LEU A 156
ILE A  84
ALA A  83
 None
 0.71A 2i2zA-2ik8A:
undetectable		 2i2zA-2ik8A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 2ik8 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(I),
ALPHA-1 SUBUNIT
(Homo
sapiens) 		4 / 8 SER A  44
SER A  47
GLY A 203
GLY A  40
 GDP  A 401 (-3.6A)
MG  A 356 ( 1.9A)
ALF  A 355 (-3.3A)
None
 0.76A 2vinA-2ik8A:
undetectable		 2vinA-2ik8A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 2ik8 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(I),
ALPHA-1 SUBUNIT
(Homo
sapiens) 		4 / 6 HIS A 322
THR A 324
PHE A 323
LEU A 266
 None
 1.07A 3bgdA-2ik8A:
2.4		 3bgdA-2ik8A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ik8 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(I),
ALPHA-1 SUBUNIT
(Homo
sapiens) 		4 / 8 LEU A 283
LEU A 268
ILE A 278
PHE A 274
 None
 0.91A 3ln1A-2ik8A:
undetectable		 3ln1A-2ik8A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ik8 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(I),
ALPHA-1 SUBUNIT
(Homo
sapiens) 		4 / 7 LEU A 283
LEU A 268
ILE A 278
PHE A 274
 None
 0.90A 3ln1B-2ik8A:
undetectable		 3ln1B-2ik8A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 2ik8 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(I),
ALPHA-1 SUBUNIT
(Homo
sapiens) 		4 / 6 SER A  44
SER A  47
GLY A 203
GLY A  40
 GDP  A 401 (-3.6A)
MG  A 356 ( 1.9A)
ALF  A 355 (-3.3A)
None
 0.71A 3rxfA-2ik8A:
undetectable		 3rxfA-2ik8A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UF8_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 2ik8 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(I),
ALPHA-1 SUBUNIT
(Homo
sapiens) 		5 / 10 PHE A 189
VAL A  50
ILE A  49
ILE A 265
PHE A 336
 None
 1.46A 3uf8A-2ik8A:
undetectable		 3uf8A-2ik8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQA_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 2ik8 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(I),
ALPHA-1 SUBUNIT
(Homo
sapiens) 		5 / 10 PHE A 189
VAL A  50
ILE A  49
ILE A 265
PHE A 336
 None
 1.40A 3uqaA-2ik8A:
undetectable		 3uqaA-2ik8A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 2ik8 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(I),
ALPHA-1 SUBUNIT
(Homo
sapiens) 		5 / 12 ILE A 127
LEU A 159
ILE A 162
ALA A 163
ILE A  82
 None
 1.02A 3vrmA-2ik8A:
undetectable		 3vrmA-2ik8A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 2ik8 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(I),
ALPHA-1 SUBUNIT
(Homo
sapiens) 		4 / 6 ASP A 158
ASN A 157
ALA A 153
ASP A 173
 None
 0.97A 4mdbA-2ik8A:
undetectable		 4mdbA-2ik8A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2ik8 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(I),
ALPHA-1 SUBUNIT
(Homo
sapiens) 		4 / 5 ASN A 269
GLY A  45
ASP A 158
ASP A 150
 GDP  A 401 (-3.1A)
GDP  A 401 (-3.3A)
None
None
 1.12A 4n48B-2ik8A:
undetectable		 4n48B-2ik8A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2ik8 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(I),
ALPHA-1 SUBUNIT
(Homo
sapiens) 		4 / 4 ASN A 269
GLY A  45
ASP A 158
ASP A 150
 GDP  A 401 (-3.1A)
GDP  A 401 (-3.3A)
None
None
 1.12A 4n49A-2ik8A:
undetectable		 4n49A-2ik8A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 2ik8 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(I),
ALPHA-1 SUBUNIT
(Homo
sapiens) 		6 / 12 GLY A  45
GLY A  42
GLY A 203
SER A  44
ALA A 326
THR A 327
 GDP  A 401 (-3.3A)
ALF  A 355 (-3.3A)
ALF  A 355 (-3.3A)
GDP  A 401 (-3.6A)
GDP  A 401 (-3.2A)
GDP  A 401 (-3.3A)
 1.40A 4uckA-2ik8A:
undetectable		 4uckA-2ik8A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_1
(PEPTIDYLPROLYL
ISOMERASE)		 2ik8 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(I),
ALPHA-1 SUBUNIT
(Homo
sapiens) 		5 / 10 PHE A 189
VAL A  50
ILE A  49
ILE A 265
PHE A 336
 None
 1.48A 6mkeD-2ik8A:
undetectable		 6mkeD-2ik8A:
12.58