SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iks'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RA8_A_FOLA161_1 (DIHYDROFOLATE REDUCTASE)	2iks	DNA-BINDING TRANSCRIPTIONAL DUAL REGULATOR (Escherichia coli)	3 / 3	ASP A 163 LYS A 322 ARG A 292	None	1.02A	1ra8A-2iksA: 2.3	1ra8A-2iksA: 21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IVU_A_ZD6A3015_1 (PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET PRECURSOR)	2iks	DNA-BINDING TRANSCRIPTIONAL DUAL REGULATOR (Escherichia coli)	3 / 3	ALA A 217 GLY A 252 SER A 246	None	0.50A	2ivuA-2iksA: undetectable	2ivuA-2iksA: 24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HJO_B_EAAB211_1 (GLUTATHIONE S-TRANSFERASE P)	2iks	DNA-BINDING TRANSCRIPTIONAL DUAL REGULATOR (Escherichia coli)	4 / 8	VAL A 118 ILE A 144 VAL A 123 GLY A 65	None	0.76A	3hjoB-2iksA: undetectable	3hjoB-2iksA: 21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UT5_D_LOCD502_1 (TUBULIN BETA CHAIN)	2iks	DNA-BINDING TRANSCRIPTIONAL DUAL REGULATOR (Escherichia coli)	5 / 12	LEU A 147 ALA A 297 ASN A 81 ALA A 87 ILE A 96	None	1.12A	3ut5D-2iksA: 3.5	3ut5D-2iksA: 20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4O2B_D_LOCD503_1 (TUBULIN ALPHA-1B CHAIN TUBULIN BETA-2B CHAIN)	2iks	DNA-BINDING TRANSCRIPTIONAL DUAL REGULATOR (Escherichia coli)	3 / 3	SER A 124 ALA A 146 VAL A 145	None	0.67A	4o2bC-2iksA: undetectable	4o2bC-2iksA: 23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4USW_A_ACTA1470_0 (ADENYLATE CYCLASE TYPE 10)	2iks	DNA-BINDING TRANSCRIPTIONAL DUAL REGULATOR (Escherichia coli)	4 / 6	LEU A 250 LEU A 287 VAL A 286 PHE A 243	None	1.11A	4uswA-2iksA: undetectable	4uswA-2iksA: 20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4X20_D_LOCD502_1 (TUBULIN ALPHA CHAIN TUBULIN BETA CHAIN)	2iks	DNA-BINDING TRANSCRIPTIONAL DUAL REGULATOR (Escherichia coli)	3 / 3	SER A 124 ALA A 146 VAL A 145	None	0.57A	4x20C-2iksA: undetectable	4x20C-2iksA: 23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIW_D_LOCD503_2 (TUBULIN BETA CHAIN)	2iks	DNA-BINDING TRANSCRIPTIONAL DUAL REGULATOR (Escherichia coli)	5 / 12	LEU A 147 ALA A 297 ASN A 81 ALA A 87 ILE A 96	None	1.16A	5xiwD-2iksA: undetectable	5xiwD-2iksA: 15.36

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1RA8_A_FOLA161_1","DIHYDROFOLATE REDUCTASE","2iks","DNA-BINDING TRANSCRIPTIONAL DUAL REGULATOR","Escherichia coli",3,"ASP A 163;LYS A 322;ARG A 292","None","1.02A","1ra8A-2iksA:2.3","1ra8A-2iksA:21.38"],["2IVU_A_ZD6A3015_1","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET PRECURSOR","2iks","DNA-BINDING TRANSCRIPTIONAL DUAL REGULATOR","Escherichia coli",3,"ALA A 217;GLY A 252;SER A 246","None","0.50A","2ivuA-2iksA:undetectable","2ivuA-2iksA:24.53"],["3HJO_B_EAAB211_1","GLUTATHIONE S-TRANSFERASE P","2iks","DNA-BINDING TRANSCRIPTIONAL DUAL REGULATOR","Escherichia coli",4,"VAL A 118;ILE A 144;VAL A 123;GLY A  65","None","0.76A","3hjoB-2iksA:undetectable","3hjoB-2iksA:21.89"],["3UT5_D_LOCD502_1","TUBULIN BETA CHAIN","2iks","DNA-BINDING TRANSCRIPTIONAL DUAL REGULATOR","Escherichia coli",5,"LEU A 147;ALA A 297;ASN A  81;ALA A  87;ILE A  96","None","1.12A","3ut5D-2iksA:3.5","3ut5D-2iksA:20.56"],["4O2B_D_LOCD503_1","TUBULIN ALPHA-1B CHAIN;TUBULIN BETA-2B CHAIN","2iks","DNA-BINDING TRANSCRIPTIONAL DUAL REGULATOR","Escherichia coli",3,"SER A 124;ALA A 146;VAL A 145","None","0.67A","4o2bC-2iksA:undetectable","4o2bC-2iksA:23.06"],["4USW_A_ACTA1470_0","ADENYLATE CYCLASE TYPE 10","2iks","DNA-BINDING TRANSCRIPTIONAL DUAL REGULATOR","Escherichia coli",4,"LEU A 250;LEU A 287;VAL A 286;PHE A 243","None","1.11A","4uswA-2iksA:undetectable","4uswA-2iksA:20.94"],["4X20_D_LOCD502_1","TUBULIN ALPHA CHAIN;TUBULIN BETA CHAIN","2iks","DNA-BINDING TRANSCRIPTIONAL DUAL REGULATOR","Escherichia coli",3,"SER A 124;ALA A 146;VAL A 145","None","0.57A","4x20C-2iksA:undetectable","4x20C-2iksA:23.06"],["5XIW_D_LOCD503_2","TUBULIN BETA CHAIN","2iks","DNA-BINDING TRANSCRIPTIONAL DUAL REGULATOR","Escherichia coli",5,"LEU A 147;ALA A 297;ASN A  81;ALA A  87;ILE A  96","None","1.16A","5xiwD-2iksA:undetectable","5xiwD-2iksA:15.36"]]