SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ill'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_B_CAMB502_0
(CYTOCHROME P450-CAM)		 2ill TITIN
(Homo
sapiens) 		4 / 5 PHE A 162
TYR A 149
VAL A 193
ASP A 170
 None
 1.48A 1dz6B-2illA:
undetectable		 1dz6B-2illA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 2ill TITIN
(Homo
sapiens) 		4 / 7 LEU A  12
ALA A  90
LEU A  92
VAL A  77
 None
 0.83A 1tyrB-2illA:
undetectable		 1tyrB-2illA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2ill TITIN
(Homo
sapiens) 		4 / 8 THR A  68
GLN A  17
ASP A  71
SER A  66
 None
 0.80A 2xz5A-2illA:
undetectable
2xz5C-2illA:
undetectable		 2xz5A-2illA:
19.82
2xz5C-2illA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2ill TITIN
(Homo
sapiens) 		4 / 8 THR A  68
GLN A  17
ASP A  71
SER A  66
 None
 0.81A 2xz5C-2illA:
undetectable
2xz5D-2illA:
undetectable		 2xz5C-2illA:
19.82
2xz5D-2illA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 2ill TITIN
(Homo
sapiens) 		4 / 4 THR A  27
VAL A  34
GLY A  88
THR A  89
 None
 1.06A 3cflA-2illA:
undetectable		 3cflA-2illA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_A_1FLA502_1
(TRANSTHYRETIN)		 2ill TITIN
(Homo
sapiens) 		4 / 7 LEU A  12
ALA A  90
LEU A  92
VAL A  77
 None
 0.98A 3d2tA-2illA:
undetectable		 3d2tA-2illA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ill TITIN
(Homo
sapiens) 		4 / 7 VAL A 151
LEU A 160
SER A 159
VAL A 176
 None
 0.84A 3hs6B-2illA:
undetectable		 3hs6B-2illA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2ill TITIN
(Homo
sapiens) 		5 / 11 LEU A 160
VAL A 120
SER A 121
ILE A 143
ALA A 171
 None
 1.07A 3mdtB-2illA:
undetectable		 3mdtB-2illA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)		 2ill TITIN
(Homo
sapiens) 		4 / 5 LEU A  12
ALA A  90
LEU A  92
VAL A  77
 None
 0.96A 5cr1A-2illA:
undetectable		 5cr1A-2illA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2ill TITIN
(Homo
sapiens) 		4 / 6 GLN A  17
VAL A  67
ALA A  20
THR A  21
 None
 1.03A 6cduB-2illA:
undetectable
6cduC-2illA:
2.2		 6cduB-2illA:
19.51
6cduC-2illA:
19.51