SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ilr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2ilr FANCONI ANEMIA GROUP
E PROTEIN
(Homo
sapiens) 		5 / 9 LEU A 403
ASP A 404
LEU A 407
ILE A 372
THR A 395
 None
 1.37A 1hzeA-2ilrA:
undetectable
1hzeB-2ilrA:
undetectable		 1hzeA-2ilrA:
15.74
1hzeB-2ilrA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2ilr FANCONI ANEMIA GROUP
E PROTEIN
(Homo
sapiens) 		5 / 9 THR A 395
LEU A 403
ASP A 404
LEU A 407
ILE A 372
 None
 1.37A 1hzeA-2ilrA:
undetectable
1hzeB-2ilrA:
undetectable		 1hzeA-2ilrA:
15.74
1hzeB-2ilrA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 2ilr FANCONI ANEMIA GROUP
E PROTEIN
(Homo
sapiens) 		4 / 8 SER A 389
PHE A 390
LEU A 355
LEU A 333
 None
 0.93A 2bfpC-2ilrA:
undetectable		 2bfpC-2ilrA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 2ilr FANCONI ANEMIA GROUP
E PROTEIN
(Homo
sapiens) 		4 / 8 SER A 389
PHE A 390
LEU A 355
LEU A 333
 None
 0.90A 2bfpD-2ilrA:
undetectable		 2bfpD-2ilrA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ilr FANCONI ANEMIA GROUP
E PROTEIN
(Homo
sapiens) 		6 / 12 LEU A 387
LEU A 429
ILE A 372
LEU A 438
VAL A 462
VAL A 453
 None
 1.47A 2pnjA-2ilrA:
undetectable		 2pnjA-2ilrA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 2ilr FANCONI ANEMIA GROUP
E PROTEIN
(Homo
sapiens) 		4 / 8 GLN A 330
LEU A 326
LYS A 282
LEU A 288
 None
 1.18A 2xn3A-2ilrA:
undetectable
2xn3B-2ilrA:
undetectable		 2xn3A-2ilrA:
23.58
2xn3B-2ilrA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 2ilr FANCONI ANEMIA GROUP
E PROTEIN
(Homo
sapiens) 		5 / 10 PHE A 368
GLY A 370
VAL A 398
LEU A 367
PHE A 390
 None
 1.27A 3ay0B-2ilrA:
undetectable		 3ay0B-2ilrA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2ilr FANCONI ANEMIA GROUP
E PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 373
GLY A 413
ALA A 415
THR A 417
LEU A 452
 None
 0.99A 3dh0B-2ilrA:
undetectable		 3dh0B-2ilrA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 2ilr FANCONI ANEMIA GROUP
E PROTEIN
(Homo
sapiens) 		3 / 3 GLU A 506
LEU A 510
LEU A 476
 None
 0.54A 3ohtA-2ilrA:
undetectable		 3ohtA-2ilrA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 2ilr FANCONI ANEMIA GROUP
E PROTEIN
(Homo
sapiens) 		3 / 3 GLU A 506
LEU A 510
LEU A 476
 None
 0.59A 3ohtB-2ilrA:
undetectable		 3ohtB-2ilrA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_B_TESB502_1
(-)		 2ilr FANCONI ANEMIA GROUP
E PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 333
VAL A 362
LEU A 363
ILE A 284
LEU A 326
 None
 1.06A 5og9B-2ilrA:
undetectable		 5og9B-2ilrA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 2ilr FANCONI ANEMIA GROUP
E PROTEIN
(Homo
sapiens) 		4 / 5 LEU A 402
LEU A 420
MET A 426
TYR A 394
 None
 1.42A 5uc3A-2ilrA:
undetectable		 5uc3A-2ilrA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_ACTA405_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 2ilr FANCONI ANEMIA GROUP
E PROTEIN
(Homo
sapiens) 		4 / 6 THR A 450
PRO A 445
GLN A 408
ILE A 441
 None
 1.42A 6ef6A-2ilrA:
undetectable		 6ef6A-2ilrA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2ilr FANCONI ANEMIA GROUP
E PROTEIN
(Homo
sapiens) 		3 / 3 LEU A 492
ASN A 503
LEU A 512
 None
 0.54A 6exiA-2ilrA:
undetectable		 6exiA-2ilrA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 2ilr FANCONI ANEMIA GROUP
E PROTEIN
(Homo
sapiens) 		3 / 3 ASN A 359
PRO A 321
GLN A 323
 None
 0.86A 6jnhA-2ilrA:
undetectable		 6jnhA-2ilrA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 2ilr FANCONI ANEMIA GROUP
E PROTEIN
(Homo
sapiens) 		3 / 3 ASN A 359
PRO A 321
GLN A 323
 None
 0.84A 6jogA-2ilrA:
undetectable		 6jogA-2ilrA:
19.62