SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2im5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_1
(GLYCINE
N-METHYLTRANSFERASE)		 2im5 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Porphyromonas
gingivalis) 		4 / 5 ARG A 168
ASP A 250
SER A 369
SER A 305
 None
 1.31A 1kiaB-2im5A:
undetectable		 1kiaB-2im5A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_1
(GLYCINE
N-METHYLTRANSFERASE)		 2im5 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Porphyromonas
gingivalis) 		4 / 6 ARG A 168
ASP A 250
SER A 369
SER A 305
 None
 1.30A 1kiaC-2im5A:
undetectable		 1kiaC-2im5A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2im5 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Porphyromonas
gingivalis) 		4 / 7 PHE A 165
ARG A 168
ARG A 273
ASP A  11
 None
 1.06A 2e5dA-2im5A:
10.0
2e5dB-2im5A:
10.0		 2e5dA-2im5A:
23.24
2e5dB-2im5A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2im5 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Porphyromonas
gingivalis) 		4 / 7 ASP A  11
PHE A 165
ARG A 168
ARG A 273
 None
 1.12A 2e5dA-2im5A:
10.0
2e5dB-2im5A:
10.0		 2e5dA-2im5A:
23.24
2e5dB-2im5A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 2im5 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Porphyromonas
gingivalis) 		5 / 6 PHE A 165
ARG A 168
GLY A 209
THR A 210
ARG A 273
 None
 1.00A 2f7fA-2im5A:
10.6		 2f7fA-2im5A:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 2im5 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Porphyromonas
gingivalis) 		4 / 6 PHE A 165
ARG A 168
SER A 195
THR A 210
 None
 1.09A 2f7fA-2im5A:
10.6		 2f7fA-2im5A:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 2im5 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Porphyromonas
gingivalis) 		4 / 6 ILE A   4
ARG A   5
LEU A  60
LEU A 173
 None
 0.87A 2rlfA-2im5A:
undetectable
2rlfD-2im5A:
undetectable		 2rlfA-2im5A:
7.44
2rlfD-2im5A:
7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 2im5 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Porphyromonas
gingivalis) 		5 / 12 LEU A 124
ASP A   9
GLY A 166
GLY A 331
THR A 335
 None
 1.12A 2uvnA-2im5A:
undetectable		 2uvnA-2im5A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF3_A_PAUA314_0
(PANTOTHENATE KINASE)		 2im5 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Porphyromonas
gingivalis) 		4 / 6 TYR A 290
PHE A 261
MET A 258
PHE A 257
 None
 1.25A 3af3A-2im5A:
undetectable		 3af3A-2im5A:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2im5 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Porphyromonas
gingivalis) 		3 / 3 GLY A 329
PRO A 310
LEU A 334
 None
 0.55A 3hcpB-2im5A:
undetectable		 3hcpB-2im5A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2im5 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Porphyromonas
gingivalis) 		4 / 5 PHE A 171
TYR A 131
LEU A 334
ARG A 169
 None
 1.27A 3sudD-2im5A:
undetectable		 3sudD-2im5A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 2im5 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Porphyromonas
gingivalis) 		4 / 4 ASP A 306
ASP A 275
GLY A 329
THR A 246
 None
 1.32A 3tl9B-2im5A:
undetectable		 3tl9B-2im5A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2im5 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Porphyromonas
gingivalis) 		4 / 7 TYR A 252
GLU A 214
TYR A  13
TYR A  21
 None
 1.29A 3ugrA-2im5A:
5.6		 3ugrA-2im5A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 2im5 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Porphyromonas
gingivalis) 		4 / 7 TYR A 225
TYR A 252
LEU A 389
ASN A 229
 None
 1.40A 4f8yC-2im5A:
undetectable
4f8yD-2im5A:
undetectable		 4f8yC-2im5A:
21.43
4f8yD-2im5A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 2im5 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Porphyromonas
gingivalis) 		4 / 6 ASN A 196
ASP A 177
PRO A 122
THR A 121
 None
 1.02A 4l1aB-2im5A:
undetectable		 4l1aB-2im5A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2im5 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Porphyromonas
gingivalis) 		4 / 5 ILE A 347
ARG A  39
ASP A 100
VAL A  50
 None
 1.26A 4nkxD-2im5A:
undetectable		 4nkxD-2im5A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_F_ACTF1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 2im5 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Porphyromonas
gingivalis) 		3 / 3 TYR A  13
THR A 210
THR A  17
 None
 0.83A 5aoxE-2im5A:
undetectable		 5aoxE-2im5A:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 2im5 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Porphyromonas
gingivalis) 		5 / 9 THR A 180
GLY A 166
THR A 335
VAL A 175
VAL A 179
 None
 1.38A 5cp4A-2im5A:
undetectable		 5cp4A-2im5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2im5 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Porphyromonas
gingivalis) 		4 / 4 GLU A 120
PRO A 122
ILE A 123
LEU A 124
 None
 1.08A 5m45A-2im5A:
undetectable		 5m45A-2im5A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2im5 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Porphyromonas
gingivalis) 		4 / 4 GLU A 120
PRO A 122
ILE A 123
LEU A 124
 None
 1.10A 5m45D-2im5A:
undetectable		 5m45D-2im5A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2im5 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Porphyromonas
gingivalis) 		4 / 4 GLU A 120
PRO A 122
ILE A 123
LEU A 124
 None
 1.07A 5m45G-2im5A:
undetectable		 5m45G-2im5A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2im5 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Porphyromonas
gingivalis) 		4 / 4 GLU A 120
PRO A 122
ILE A 123
LEU A 124
 None
 1.07A 5m45J-2im5A:
undetectable		 5m45J-2im5A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 2im5 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Porphyromonas
gingivalis) 		5 / 11 SER A 195
THR A 194
VAL A 126
ALA A 200
TYR A  13
 None
 1.13A 6dryA-2im5A:
undetectable		 6dryA-2im5A:
21.90