SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2im9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 2im9 HYPOTHETICAL PROTEIN
(Legionella
pneumophila) 		4 / 6 TYR A  92
GLY A  98
PHE A 108
ARG A 156
 None
 1.35A 2a3cA-2im9A:
undetectable		 2a3cA-2im9A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 2im9 HYPOTHETICAL PROTEIN
(Legionella
pneumophila) 		4 / 6 TYR A  92
GLY A  98
PHE A 108
ARG A 156
 None
 1.33A 2a3cB-2im9A:
undetectable		 2a3cB-2im9A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_D_CHDD702_0
(FERROCHELATASE)		 2im9 HYPOTHETICAL PROTEIN
(Legionella
pneumophila) 		3 / 3 ARG A 145
GLY A 100
PRO A 101
 None
 0.55A 2hreD-2im9A:
undetectable		 2hreD-2im9A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 2im9 HYPOTHETICAL PROTEIN
(Legionella
pneumophila) 		5 / 12 ILE A 162
ILE A 283
THR A 285
LEU A 287
HIS A 158
 None
 1.19A 2qo5A-2im9A:
undetectable		 2qo5A-2im9A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0Y_A_X0TA1625_1
(O-GLCNACASE NAGJ)		 2im9 HYPOTHETICAL PROTEIN
(Legionella
pneumophila) 		5 / 12 ASP A 119
VAL A 122
ASN A 165
VAL A 242
ASP A 288
 None
 0.95A 2x0yA-2im9A:
undetectable		 2x0yA-2im9A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0Y_B_X0TB1625_1
(O-GLCNACASE NAGJ)		 2im9 HYPOTHETICAL PROTEIN
(Legionella
pneumophila) 		5 / 12 ASP A 119
VAL A 122
ASN A 165
VAL A 242
ASP A 288
 None
 0.99A 2x0yB-2im9A:
undetectable		 2x0yB-2im9A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2im9 HYPOTHETICAL PROTEIN
(Legionella
pneumophila) 		5 / 11 ALA A 249
ILE A 264
LEU A 319
PHE A 261
THR A 248
 None
 1.10A 3fl9C-2im9A:
undetectable		 3fl9C-2im9A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2im9 HYPOTHETICAL PROTEIN
(Legionella
pneumophila) 		5 / 10 ALA A 249
ILE A 264
LEU A 319
PHE A 261
THR A 248
 None
 1.10A 3fl9E-2im9A:
undetectable		 3fl9E-2im9A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2im9 HYPOTHETICAL PROTEIN
(Legionella
pneumophila) 		5 / 12 ALA A 249
ILE A 264
LEU A 319
PHE A 261
THR A 248
 None
 1.12A 3fl9G-2im9A:
undetectable		 3fl9G-2im9A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2im9 HYPOTHETICAL PROTEIN
(Legionella
pneumophila) 		5 / 9 ALA A 249
ILE A 264
LEU A 319
PHE A 261
THR A 248
 None
 1.12A 3fl9H-2im9A:
undetectable		 3fl9H-2im9A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2im9 HYPOTHETICAL PROTEIN
(Legionella
pneumophila) 		3 / 3 ILE A 335
PHE A 247
HIS A 291
 None
 0.65A 3h0aA-2im9A:
undetectable		 3h0aA-2im9A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 2im9 HYPOTHETICAL PROTEIN
(Legionella
pneumophila) 		3 / 3 SER A  59
SER A  60
HIS A  66
 None
 0.82A 3mzeA-2im9A:
undetectable		 3mzeA-2im9A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_A_URFA521_1
(RNA DEPENDENT RNA
POLYMERASE)		 2im9 HYPOTHETICAL PROTEIN
(Legionella
pneumophila) 		4 / 5 ARG A 212
ASP A 117
ASP A 119
ARG A 156
 None
 1.27A 3naiA-2im9A:
undetectable		 3naiA-2im9A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_C_URFC521_1
(RNA DEPENDENT RNA
POLYMERASE)		 2im9 HYPOTHETICAL PROTEIN
(Legionella
pneumophila) 		4 / 5 ARG A 212
ASP A 117
ASP A 119
ARG A 156
 None
 1.26A 3naiC-2im9A:
undetectable		 3naiC-2im9A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 2im9 HYPOTHETICAL PROTEIN
(Legionella
pneumophila) 		4 / 7 ILE A 335
LEU A 250
THR A 178
ILE A 181
 None
 0.86A 3p50A-2im9A:
undetectable		 3p50A-2im9A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 2im9 HYPOTHETICAL PROTEIN
(Legionella
pneumophila) 		4 / 7 ILE A 335
LEU A 250
THR A 178
ILE A 181
 None
 0.86A 3p50B-2im9A:
undetectable		 3p50B-2im9A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 2im9 HYPOTHETICAL PROTEIN
(Legionella
pneumophila) 		4 / 7 ILE A 335
LEU A 250
THR A 178
ILE A 181
 None
 0.87A 3p50C-2im9A:
undetectable		 3p50C-2im9A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 2im9 HYPOTHETICAL PROTEIN
(Legionella
pneumophila) 		4 / 7 ILE A 335
LEU A 250
THR A 178
ILE A 181
 None
 0.87A 3p50D-2im9A:
undetectable		 3p50D-2im9A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 2im9 HYPOTHETICAL PROTEIN
(Legionella
pneumophila) 		4 / 7 ILE A 335
LEU A 250
THR A 178
ILE A 181
 None
 0.91A 3p50E-2im9A:
undetectable		 3p50E-2im9A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2im9 HYPOTHETICAL PROTEIN
(Legionella
pneumophila) 		5 / 12 ILE A 289
ASP A 288
ASP A 163
ILE A 162
GLU A 236
 None
 1.21A 4i41A-2im9A:
undetectable		 4i41A-2im9A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 2im9 HYPOTHETICAL PROTEIN
(Legionella
pneumophila) 		5 / 10 ILE A 337
ILE A 270
ILE A 272
ILE A 273
ILE A 289
 None
 1.10A 5murE-2im9A:
undetectable		 5murE-2im9A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 2im9 HYPOTHETICAL PROTEIN
(Legionella
pneumophila) 		5 / 9 LEU A 126
SER A 127
THR A 144
PRO A 342
PHE A 352
 None
 1.26A 6ef6A-2im9A:
undetectable		 6ef6A-2im9A:
21.23