SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ime'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG2_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 2ime 2-HYDROXYCHROMENE-2-
CARBOXYLATE
ISOMERASE
(Pseudomonas
putida) 		4 / 5 ASN A 181
TRP A 179
VAL A 168
PRO A 169
 None
GSH  A 301 (-4.0A)
GSH  A 301 (-4.2A)
None
 1.31A 1rg2A-2imeA:
0.3		 1rg2A-2imeA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RGU_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 2ime 2-HYDROXYCHROMENE-2-
CARBOXYLATE
ISOMERASE
(Pseudomonas
putida) 		4 / 5 ASN A 181
TRP A 179
VAL A 168
PRO A 169
 None
GSH  A 301 (-4.0A)
GSH  A 301 (-4.2A)
None
 1.32A 1rguA-2imeA:
0.8		 1rguA-2imeA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 2ime 2-HYDROXYCHROMENE-2-
CARBOXYLATE
ISOMERASE
(Pseudomonas
putida) 		3 / 3 PHE A   7
TYR A  94
TYR A 153
 None
 0.80A 1x70B-2imeA:
undetectable		 1x70B-2imeA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_2
(POL POLYPROTEIN)		 2ime 2-HYDROXYCHROMENE-2-
CARBOXYLATE
ISOMERASE
(Pseudomonas
putida) 		3 / 3 ASP A   8
VAL A 109
PRO A 126
 None
 0.74A 2avvA-2imeA:
undetectable		 2avvA-2imeA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2ime 2-HYDROXYCHROMENE-2-
CARBOXYLATE
ISOMERASE
(Pseudomonas
putida) 		4 / 8 ASN A  18
SER A  14
PHE A   5
VAL A 106
 None
 1.15A 2wekA-2imeA:
undetectable		 2wekA-2imeA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2ime 2-HYDROXYCHROMENE-2-
CARBOXYLATE
ISOMERASE
(Pseudomonas
putida) 		4 / 8 ASN A  18
SER A  14
VAL A 106
ASN A  35
 None
 1.09A 2wekA-2imeA:
undetectable		 2wekA-2imeA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2ime 2-HYDROXYCHROMENE-2-
CARBOXYLATE
ISOMERASE
(Pseudomonas
putida) 		4 / 8 ASN A  18
SER A  14
VAL A 106
ASN A  35
 None
 1.07A 2wekB-2imeA:
undetectable		 2wekB-2imeA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 2ime 2-HYDROXYCHROMENE-2-
CARBOXYLATE
ISOMERASE
(Pseudomonas
putida) 		4 / 8 ARG A 163
VAL A 165
ILE A  37
GLN A 156
 None
 1.01A 3remA-2imeA:
undetectable		 3remA-2imeA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 2ime 2-HYDROXYCHROMENE-2-
CARBOXYLATE
ISOMERASE
(Pseudomonas
putida) 		4 / 8 ARG A 163
VAL A 165
ILE A  37
GLN A 156
 None
 0.96A 3remB-2imeA:
undetectable		 3remB-2imeA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 2ime 2-HYDROXYCHROMENE-2-
CARBOXYLATE
ISOMERASE
(Pseudomonas
putida) 		4 / 6 LEU A  10
PRO A  12
PRO A  81
TYR A  84
 2C2  A 305 ( 4.2A)
GSH  A 301 ( 4.5A)
None
TOH  A 304 (-4.0A)
 1.47A 3vkxA-2imeA:
undetectable		 3vkxA-2imeA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRQ_C_AVLC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 2ime 2-HYDROXYCHROMENE-2-
CARBOXYLATE
ISOMERASE
(Pseudomonas
putida) 		4 / 7 PHE A   9
TYR A 105
PRO A 126
PHE A 140
 None
 1.32A 4grqA-2imeA:
undetectable
4grqC-2imeA:
undetectable		 4grqA-2imeA:
18.52
4grqC-2imeA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)		 2ime 2-HYDROXYCHROMENE-2-
CARBOXYLATE
ISOMERASE
(Pseudomonas
putida) 		5 / 11 SER A  96
VAL A 129
SER A 130
LEU A 133
LEU A 144
 None
 0.89A 4or0B-2imeA:
undetectable		 4or0B-2imeA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2ime 2-HYDROXYCHROMENE-2-
CARBOXYLATE
ISOMERASE
(Pseudomonas
putida) 		4 / 8 PHE A  80
ALA A  71
LEU A  78
PHE A 166
 TOH  A 304 (-4.8A)
None
None
None
 1.03A 4rkuA-2imeA:
undetectable
4rkuJ-2imeA:
undetectable		 4rkuA-2imeA:
14.33
4rkuJ-2imeA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 2ime 2-HYDROXYCHROMENE-2-
CARBOXYLATE
ISOMERASE
(Pseudomonas
putida) 		5 / 12 GLY A 174
ASP A 175
ARG A 183
LEU A 184
MET A 171
 None
 1.13A 5h5fA-2imeA:
undetectable		 5h5fA-2imeA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2ime 2-HYDROXYCHROMENE-2-
CARBOXYLATE
ISOMERASE
(Pseudomonas
putida) 		5 / 8 ILE A 118
GLY A 117
PHE A   7
PHE A  93
ASN A  83
 None
 1.32A 5hieD-2imeA:
undetectable		 5hieD-2imeA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 2ime 2-HYDROXYCHROMENE-2-
CARBOXYLATE
ISOMERASE
(Pseudomonas
putida) 		4 / 6 GLN A  19
VAL A 106
MET A 191
ARG A 183
 None
 1.13A 6brdB-2imeA:
undetectable		 6brdB-2imeA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2ime 2-HYDROXYCHROMENE-2-
CARBOXYLATE
ISOMERASE
(Pseudomonas
putida) 		4 / 8 PRO A 126
ALA A 149
THR A 150
TYR A 153
 None
 0.90A 6cduD-2imeA:
undetectable
6cduE-2imeA:
undetectable		 6cduD-2imeA:
20.31
6cduE-2imeA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)		 2ime 2-HYDROXYCHROMENE-2-
CARBOXYLATE
ISOMERASE
(Pseudomonas
putida) 		4 / 6 ARG A  41
ILE A  91
ASN A  90
ASP A  38
 None
 1.33A 6dhbA-2imeA:
undetectable		 6dhbA-2imeA:
17.24