SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iml'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 2iml HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		4 / 6 ILE A  15
ALA A  17
THR A  19
ALA A 105
 None
 0.90A 1w0gA-2imlA:
undetectable		 1w0gA-2imlA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 2iml HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		5 / 11 ILE A  15
ALA A  17
THR A  52
ARG A 108
LEU A  56
 None
None
FMN  A 200 (-3.7A)
None
None
 1.17A 2v0mD-2imlA:
undetectable		 2v0mD-2imlA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 2iml HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		4 / 7 ALA A  64
ALA A  17
THR A  52
LEU A  47
 None
None
FMN  A 200 (-3.7A)
FMN  A 200 (-4.5A)
 0.95A 2wx2A-2imlA:
undetectable		 2wx2A-2imlA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 2iml HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		5 / 11 LEU A  47
LEU A 114
ALA A  45
ASN A  13
ALA A  64
 FMN  A 200 (-4.5A)
None
None
None
None
 1.19A 3e22B-2imlA:
undetectable		 3e22B-2imlA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)		 2iml HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		5 / 11 LEU A  47
LEU A 114
ALA A  45
ASN A  13
ALA A  64
 FMN  A 200 (-4.5A)
None
None
None
None
 1.17A 3e22D-2imlA:
undetectable		 3e22D-2imlA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 2iml HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		4 / 8 ALA A  64
ALA A  17
THR A  52
LEU A  47
 None
None
FMN  A 200 (-3.7A)
FMN  A 200 (-4.5A)
 0.88A 3khmA-2imlA:
undetectable		 3khmA-2imlA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2iml HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		4 / 8 ASN A  27
THR A  19
LEU A  56
ALA A  54
 FMN  A 200 (-2.9A)
None
None
None
 1.00A 3kp6A-2imlA:
undetectable		 3kp6A-2imlA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 2iml HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 LEU A  47
ALA A  64
ASN A  65
THR A  52
LEU A  56
 FMN  A 200 (-4.5A)
None
None
FMN  A 200 (-3.7A)
None
 1.04A 3vaqB-2imlA:
undetectable		 3vaqB-2imlA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 2iml HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		5 / 11 VAL A 136
LEU A 140
GLU A 182
ALA A 180
VAL A 169
 None
FMN  A 200 (-3.9A)
None
None
None
 1.11A 4e0fA-2imlA:
undetectable		 4e0fA-2imlA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 2iml HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 MET A 185
ALA A 143
HIS A 142
LEU A 140
ALA A 139
 None
None
None
FMN  A 200 (-3.9A)
None
 1.04A 5k9dA-2imlA:
undetectable		 5k9dA-2imlA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 2iml HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		3 / 3 MET A 185
GLU A 167
ARG A 166
 None
 1.12A 5tjyA-2imlA:
undetectable		 5tjyA-2imlA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 2iml HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		3 / 3 MET A 185
GLU A 167
ARG A 166
 None
 1.09A 5tjzA-2imlA:
undetectable		 5tjzA-2imlA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 2iml HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		4 / 8 ILE A  15
PHE A  63
ALA A 105
LEU A  56
 None
 0.83A 5y7pC-2imlA:
undetectable		 5y7pC-2imlA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2iml HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		5 / 10 ILE A  31
ILE A 162
ALA A 139
LEU A 140
ALA A  74
 FMN  A 200 (-3.8A)
None
None
FMN  A 200 (-3.9A)
None
 1.48A 5zjiB-2imlA:
2.5		 5zjiB-2imlA:
20.10