SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2in2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 2in2 PICORNAIN 3C
(Rhinovirus
B) 		5 / 12 ILE A  90
LEU A  72
SER A 170
ILE A 135
LEU A  94
 None
 1.05A 1drfA-2in2A:
undetectable		 1drfA-2in2A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 2in2 PICORNAIN 3C
(Rhinovirus
B) 		5 / 12 VAL A  47
LEU A  77
GLY A  44
PRO A  43
MET A  16
 None
 1.41A 1fdsA-2in2A:
undetectable		 1fdsA-2in2A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)		 2in2 PICORNAIN 3C
(Rhinovirus
B) 		5 / 11 LEU A 173
ILE A 156
PHE A  89
ARG A  87
GLY A  88
 None
 1.30A 2bxmA-2in2A:
undetectable		 2bxmA-2in2A:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6001_0
(PANTOTHENATE KINASE)		 2in2 PICORNAIN 3C
(Rhinovirus
B) 		5 / 11 VAL A  56
GLY A  44
THR A  73
ILE A  37
THR A  20
 None
 1.44A 2f9wA-2in2A:
undetectable
2f9wB-2in2A:
undetectable		 2f9wA-2in2A:
20.75
2f9wB-2in2A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 2in2 PICORNAIN 3C
(Rhinovirus
B) 		4 / 4 VAL A 161
ARG A 133
ILE A 124
THR A  39
 None
 0.83A 3cl9A-2in2A:
undetectable		 3cl9A-2in2A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 2in2 PICORNAIN 3C
(Rhinovirus
B) 		5 / 11 VAL A  34
ILE A  18
ILE A 159
LEU A 173
ILE A  30
 None
 1.03A 3clbA-2in2A:
undetectable		 3clbA-2in2A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2in2 PICORNAIN 3C
(Rhinovirus
B) 		5 / 10 VAL A  34
ILE A  18
ILE A 159
LEU A 173
ILE A  30
 None
 1.04A 3hbbA-2in2A:
undetectable		 3hbbA-2in2A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2in2 PICORNAIN 3C
(Rhinovirus
B) 		5 / 11 GLY A 148
ASN A 107
SER A 105
LEU A 113
LEU A 101
 None
 1.20A 3ndvC-2in2A:
undetectable
3ndvD-2in2A:
undetectable		 3ndvC-2in2A:
20.00
3ndvD-2in2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2in2 PICORNAIN 3C
(Rhinovirus
B) 		5 / 11 LEU A 113
LEU A 101
GLY A 148
ASN A 107
SER A 105
 None
 1.18A 3ndvC-2in2A:
undetectable
3ndvD-2in2A:
undetectable		 3ndvC-2in2A:
20.00
3ndvD-2in2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2in2 PICORNAIN 3C
(Rhinovirus
B) 		5 / 8 ASP A  85
ILE A  86
GLY A  88
VAL A 149
SER A 170
 None
 1.35A 4acbB-2in2A:
undetectable
4acbC-2in2A:
2.1		 4acbB-2in2A:
22.01
4acbC-2in2A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2in2 PICORNAIN 3C
(Rhinovirus
B) 		5 / 12 GLU A  92
ILE A  30
ASP A  85
GLY A  88
ILE A  90
 None
 1.32A 4djfA-2in2A:
undetectable		 4djfA-2in2A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 2in2 PICORNAIN 3C
(Rhinovirus
B) 		5 / 12 VAL A 149
LEU A  10
VAL A  36
ILE A 159
ILE A  30
 None
 1.02A 4y8wC-2in2A:
undetectable		 4y8wC-2in2A:
20.19