SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2in5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD6_0
(GRAMICIDIN A)		 2in5 HYPOTHETICAL
LIPOPROTEIN YMCC
(Escherichia
coli) 		3 / 3 TRP A 150
ALA A 172
VAL A 169
 None
 0.85A 1c4dC-2in5A:
undetectable
1c4dD-2in5A:
undetectable		 1c4dC-2in5A:
8.39
1c4dD-2in5A:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		 2in5 HYPOTHETICAL
LIPOPROTEIN YMCC
(Escherichia
coli) 		5 / 12 LEU A 183
LEU A  76
LEU A  77
LEU A  39
MET A  37
 None
 1.41A 1sqnA-2in5A:
undetectable		 1sqnA-2in5A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB6_0
(GRAMICIDIN A)		 2in5 HYPOTHETICAL
LIPOPROTEIN YMCC
(Escherichia
coli) 		3 / 3 ALA A 172
VAL A 169
TRP A 150
 None
 0.88A 1tkqB-2in5A:
undetectable		 1tkqB-2in5A:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWY_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2in5 HYPOTHETICAL
LIPOPROTEIN YMCC
(Escherichia
coli) 		4 / 7 TRP A 163
PHE A 167
VAL A 154
ARG A  75
 None
 1.41A 4cwyA-2in5A:
undetectable
4cwyB-2in5A:
undetectable		 4cwyA-2in5A:
16.70
4cwyB-2in5A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2in5 HYPOTHETICAL
LIPOPROTEIN YMCC
(Escherichia
coli) 		5 / 12 ASP A  95
PHE A 167
SER A 179
MET A 192
LEU A 183
 None
 1.49A 4iarA-2in5A:
undetectable		 4iarA-2in5A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 2in5 HYPOTHETICAL
LIPOPROTEIN YMCC
(Escherichia
coli) 		5 / 12 MET A  37
GLY A  74
LEU A  97
GLN A 178
VAL A 176
 None
 1.01A 5ubbA-2in5A:
undetectable		 5ubbA-2in5A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV9_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2in5 HYPOTHETICAL
LIPOPROTEIN YMCC
(Escherichia
coli) 		4 / 7 VAL A 154
ARG A  75
TRP A 163
PHE A 167
 None
 1.33A 5vv9A-2in5A:
0.0
5vv9B-2in5A:
0.0		 5vv9A-2in5A:
16.70
5vv9B-2in5A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVA_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2in5 HYPOTHETICAL
LIPOPROTEIN YMCC
(Escherichia
coli) 		4 / 7 VAL A 154
ARG A  75
TRP A 163
PHE A 167
 None
 1.24A 5vvaA-2in5A:
undetectable
5vvaB-2in5A:
undetectable		 5vvaA-2in5A:
16.70
5vvaB-2in5A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2in5 HYPOTHETICAL
LIPOPROTEIN YMCC
(Escherichia
coli) 		3 / 3 ARG A 111
PHE A 130
ARG A  75
 None
 0.96A 5y9yA-2in5A:
undetectable		 5y9yA-2in5A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIE_B_H4BB502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2in5 HYPOTHETICAL
LIPOPROTEIN YMCC
(Escherichia
coli) 		4 / 7 TRP A 163
PHE A 167
VAL A 154
ARG A  75
 None
 1.37A 6cieA-2in5A:
undetectable
6cieB-2in5A:
undetectable		 6cieA-2in5A:
18.09
6cieB-2in5A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIF_C_H4BC502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2in5 HYPOTHETICAL
LIPOPROTEIN YMCC
(Escherichia
coli) 		4 / 7 VAL A 154
ARG A  75
TRP A 163
PHE A 167
 None
 1.29A 6cifC-2in5A:
0.0
6cifD-2in5A:
0.0		 6cifC-2in5A:
18.09
6cifD-2in5A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2in5 HYPOTHETICAL
LIPOPROTEIN YMCC
(Escherichia
coli) 		3 / 3 LEU A  77
GLY A  74
PHE A 130
 None
 0.65A 6exiC-2in5A:
undetectable		 6exiC-2in5A:
16.91