SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2inf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2inf UROPORPHYRINOGEN
DECARBOXYLASE
(Bacillus
subtilis) 		4 / 8 ALA A  73
LEU A  75
GLY A 143
GLY A 200
 None
 0.84A 1rukH-2infA:
undetectable
1rukL-2infA:
undetectable		 1rukH-2infA:
19.83
1rukL-2infA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 2inf UROPORPHYRINOGEN
DECARBOXYLASE
(Bacillus
subtilis) 		5 / 12 SER A 153
TYR A 154
ALA A 213
GLY A 212
LEU A 214
 None
 1.21A 1vpoH-2infA:
undetectable
1vpoL-2infA:
undetectable		 1vpoH-2infA:
18.11
1vpoL-2infA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2inf UROPORPHYRINOGEN
DECARBOXYLASE
(Bacillus
subtilis) 		5 / 12 THR A 156
LEU A 180
ASP A 187
PHE A 149
VAL A 226
 None
 1.41A 2g72A-2infA:
undetectable		 2g72A-2infA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2inf UROPORPHYRINOGEN
DECARBOXYLASE
(Bacillus
subtilis) 		5 / 12 GLY A 285
ALA A 252
ILE A 279
LEU A 260
ILE A 242
 None
 0.98A 3adxB-2infA:
undetectable		 3adxB-2infA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2inf UROPORPHYRINOGEN
DECARBOXYLASE
(Bacillus
subtilis) 		3 / 3 ASP A 266
LEU A 265
GLN A 309
 None
 0.83A 3g4lA-2infA:
undetectable		 3g4lA-2infA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IEO_A_AMJA300_0
(CARBONIC ANHYDRASE 2)		 2inf UROPORPHYRINOGEN
DECARBOXYLASE
(Bacillus
subtilis) 		4 / 4 ILE A 317
GLN A 284
VAL A 262
PHE A  11
 None
 1.19A 3ieoA-2infA:
0.0		 3ieoA-2infA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA201_1
(PROTEIN S100-A4)		 2inf UROPORPHYRINOGEN
DECARBOXYLASE
(Bacillus
subtilis) 		5 / 9 GLY A 323
ILE A 142
PHE A 231
PHE A 207
GLY A 245
 None
 1.39A 3ko0A-2infA:
undetectable
3ko0C-2infA:
undetectable		 3ko0A-2infA:
14.66
3ko0C-2infA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2inf UROPORPHYRINOGEN
DECARBOXYLASE
(Bacillus
subtilis) 		5 / 12 HIS A 250
ASP A 266
GLY A 245
GLY A 212
GLY A 285
 None
 0.98A 4blvB-2infA:
undetectable		 4blvB-2infA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 2inf UROPORPHYRINOGEN
DECARBOXYLASE
(Bacillus
subtilis) 		4 / 8 VAL A 139
PRO A  24
GLN A  30
ILE A 142
 None
 1.01A 4iilA-2infA:
2.2		 4iilA-2infA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP9_A_ASCA501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 2inf UROPORPHYRINOGEN
DECARBOXYLASE
(Bacillus
subtilis) 		5 / 12 ILE A 242
GLN A 284
GLN A 205
ALA A 201
ILE A  74
 None
 1.40A 4rp9A-2infA:
0.0		 4rp9A-2infA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2inf UROPORPHYRINOGEN
DECARBOXYLASE
(Bacillus
subtilis) 		5 / 11 GLY A 285
ALA A 252
ILE A 279
LEU A 260
ILE A 242
 None
 1.03A 4xumB-2infA:
undetectable		 4xumB-2infA:
24.60