SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2inr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2inr DNA TOPOISOMERASE 4
SUBUNIT A
(Staphylococcus
aureus) 		3 / 3 ILE A 226
ASP A 213
PHE A 214
 None
 0.55A 1uwjB-2inrA:
undetectable		 1uwjB-2inrA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DXR_A_SORA1002_0
(LACTOTRANSFERRIN)		 2inr DNA TOPOISOMERASE 4
SUBUNIT A
(Staphylococcus
aureus) 		3 / 3 THR A 169
PRO A 180
TYR A 326
 None
 0.97A 2dxrA-2inrA:
undetectable		 2dxrA-2inrA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		 2inr DNA TOPOISOMERASE 4
SUBUNIT A
(Staphylococcus
aureus) 		4 / 7 THR A  66
SER A  52
SER A  51
LEU A  38
 None
 0.97A 2hdnE-2inrA:
undetectable
2hdnF-2inrA:
undetectable
2hdnH-2inrA:
undetectable		 2hdnE-2inrA:
7.81
2hdnF-2inrA:
20.62
2hdnH-2inrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		 2inr DNA TOPOISOMERASE 4
SUBUNIT A
(Staphylococcus
aureus) 		4 / 7 SER A  51
LEU A  38
THR A  66
SER A  52
 None
 1.01A 2hdnF-2inrA:
undetectable
2hdnG-2inrA:
undetectable
2hdnH-2inrA:
undetectable		 2hdnF-2inrA:
20.62
2hdnG-2inrA:
7.81
2hdnH-2inrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_B_ECNB1406_1
(CYTOCHROME P450 130)		 2inr DNA TOPOISOMERASE 4
SUBUNIT A
(Staphylococcus
aureus) 		5 / 11 ASP A 112
PRO A 114
MET A  86
THR A 120
GLY A 104
 None
 1.40A 2uvnB-2inrA:
undetectable		 2uvnB-2inrA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2inr DNA TOPOISOMERASE 4
SUBUNIT A
(Staphylococcus
aureus) 		3 / 3 SER A 334
ASP A  33
ASP A 348
 None
 0.87A 3iv6A-2inrA:
undetectable		 3iv6A-2inrA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 2inr DNA TOPOISOMERASE 4
SUBUNIT A
(Staphylococcus
aureus) 		4 / 6 ARG A 479
PHE A 214
TYR A 262
PRO A 212
 None
 1.24A 3jqaC-2inrA:
undetectable		 3jqaC-2inrA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 2inr DNA TOPOISOMERASE 4
SUBUNIT A
(Staphylococcus
aureus) 		4 / 6 ARG A 479
PHE A 214
TYR A 262
PRO A 212
 None
 1.28A 3jqaD-2inrA:
undetectable		 3jqaD-2inrA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 2inr DNA TOPOISOMERASE 4
SUBUNIT A
(Staphylococcus
aureus) 		5 / 11 GLU A 486
GLY A 222
ALA A 485
ILE A 220
ASP A 224
 None
 1.23A 3nmuB-2inrA:
2.2
3nmuJ-2inrA:
undetectable		 3nmuB-2inrA:
24.16
3nmuJ-2inrA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)		 2inr DNA TOPOISOMERASE 4
SUBUNIT A
(Staphylococcus
aureus) 		4 / 5 THR A 169
GLY A 167
PRO A 181
TYR A 262
 None
 1.26A 3u8qA-2inrA:
undetectable		 3u8qA-2inrA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_D_ACTD502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2inr DNA TOPOISOMERASE 4
SUBUNIT A
(Staphylococcus
aureus) 		3 / 3 GLY A 104
THR A 120
ASN A 106
 None
 0.69A 3v4tD-2inrA:
undetectable		 3v4tD-2inrA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 2inr DNA TOPOISOMERASE 4
SUBUNIT A
(Staphylococcus
aureus) 		3 / 3 TYR A 326
MET A 341
LEU A 163
 None
 0.92A 3vw1D-2inrA:
undetectable		 3vw1D-2inrA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2inr DNA TOPOISOMERASE 4
SUBUNIT A
(Staphylococcus
aureus) 		5 / 9 ILE A 209
MET A 206
ILE A 483
ILE A 223
ILE A 220
 None
 1.13A 3zosA-2inrA:
undetectable		 3zosA-2inrA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRK_A_KTRA713_1
(LACTOTRANSFERRIN)		 2inr DNA TOPOISOMERASE 4
SUBUNIT A
(Staphylococcus
aureus) 		4 / 5 THR A 169
GLY A 167
PRO A 180
TYR A 326
 None
 1.08A 4grkA-2inrA:
undetectable		 4grkA-2inrA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 2inr DNA TOPOISOMERASE 4
SUBUNIT A
(Staphylococcus
aureus) 		4 / 6 ASP A 178
GLY A 167
PRO A 215
THR A 216
 None
 1.02A 4l1aB-2inrA:
undetectable		 4l1aB-2inrA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 2inr DNA TOPOISOMERASE 4
SUBUNIT A
(Staphylococcus
aureus) 		3 / 3 LEU A 366
LYS A 363
THR A 362
 None
 0.59A 4lj0A-2inrA:
undetectable		 4lj0A-2inrA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 2inr DNA TOPOISOMERASE 4
SUBUNIT A
(Staphylococcus
aureus) 		4 / 7 LEU A 276
ILE A 299
ILE A 301
VAL A 288
 None
 0.77A 4ojbA-2inrA:
undetectable		 4ojbA-2inrA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2inr DNA TOPOISOMERASE 4
SUBUNIT A
(Staphylococcus
aureus) 		4 / 8 ILE A 209
LEU A 340
VAL A  34
LEU A 163
 None
 0.93A 4r38B-2inrA:
undetectable		 4r38B-2inrA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2inr DNA TOPOISOMERASE 4
SUBUNIT A
(Staphylococcus
aureus) 		4 / 6 ILE A 188
GLN A 189
ILE A 195
ASP A 196
 None
None
None
EDO  A 496 ( 3.1A)
 1.15A 4w5qA-2inrA:
undetectable		 4w5qA-2inrA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2inr DNA TOPOISOMERASE 4
SUBUNIT A
(Staphylococcus
aureus) 		4 / 6 ILE A 188
GLN A 189
ILE A 195
ASP A 196
 None
None
None
EDO  A 496 ( 3.1A)
 1.10A 4w5tA-2inrA:
undetectable		 4w5tA-2inrA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2inr DNA TOPOISOMERASE 4
SUBUNIT A
(Staphylococcus
aureus) 		4 / 6 ILE A 188
GLN A 189
ILE A 195
ASP A 196
 None
None
None
EDO  A 496 ( 3.1A)
 1.15A 4z4cA-2inrA:
undetectable		 4z4cA-2inrA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2inr DNA TOPOISOMERASE 4
SUBUNIT A
(Staphylococcus
aureus) 		4 / 6 ILE A 188
GLN A 189
ILE A 195
ASP A 196
 None
None
None
EDO  A 496 ( 3.1A)
 1.14A 4z4dA-2inrA:
undetectable		 4z4dA-2inrA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2inr DNA TOPOISOMERASE 4
SUBUNIT A
(Staphylococcus
aureus) 		4 / 6 VAL A 165
LEU A 156
SER A 158
ILE A 135
 None
 0.89A 5jw1A-2inrA:
1.5		 5jw1A-2inrA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2inr DNA TOPOISOMERASE 4
SUBUNIT A
(Staphylococcus
aureus) 		5 / 12 ILE A 179
PRO A 212
ARG A  96
HIS A  97
GLY A 167
 None
 1.05A 5k7uA-2inrA:
undetectable		 5k7uA-2inrA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 2inr DNA TOPOISOMERASE 4
SUBUNIT A
(Staphylococcus
aureus) 		4 / 6 ILE A 188
GLN A 189
ILE A 195
ASP A 196
 None
None
None
EDO  A 496 ( 3.1A)
 1.09A 6cbdA-2inrA:
undetectable		 6cbdA-2inrA:
19.88