SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2inv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2inv INSULIN
FRUCTOTRANSFERASE
(Bacillus
sp.
snu-7) 		5 / 10 ILE A  81
ALA A  99
ILE A 153
ILE A  78
THR A  54
 None
 1.18A 1j3jA-2invA:
undetectable		 1j3jA-2invA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 2inv INSULIN
FRUCTOTRANSFERASE
(Bacillus
sp.
snu-7) 		4 / 8 GLY A 286
ILE A 259
LEU A 283
ASP A 239
 None
 0.89A 1jg4A-2invA:
undetectable		 1jg4A-2invA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA156_1
(CALMODULIN)		 2inv INSULIN
FRUCTOTRANSFERASE
(Bacillus
sp.
snu-7) 		5 / 8 ILE A 100
LEU A 120
ILE A  82
VAL A 113
ILE A  78
 None
 1.35A 1linA-2invA:
undetectable		 1linA-2invA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 2inv INSULIN
FRUCTOTRANSFERASE
(Bacillus
sp.
snu-7) 		5 / 11 ILE A 331
HIS A 279
LEU A 274
ASN A 263
VAL A 237
 None
 1.24A 1mrlA-2invA:
undetectable
1mrlB-2invA:
undetectable		 1mrlA-2invA:
18.93
1mrlB-2invA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 2inv INSULIN
FRUCTOTRANSFERASE
(Bacillus
sp.
snu-7) 		5 / 12 ILE A 331
HIS A 279
LEU A 274
ASN A 263
VAL A 237
 None
 1.16A 1mrlB-2invA:
undetectable
1mrlC-2invA:
undetectable		 1mrlB-2invA:
18.93
1mrlC-2invA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2inv INSULIN
FRUCTOTRANSFERASE
(Bacillus
sp.
snu-7) 		5 / 12 LEU A 185
PHE A 165
ILE A 102
ILE A  78
THR A 157
 None
 1.14A 1re7A-2invA:
undetectable		 1re7A-2invA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		 2inv INSULIN
FRUCTOTRANSFERASE
(Bacillus
sp.
snu-7) 		4 / 5 ASP A 354
THR A 391
LEU A 394
LEU A 356
 None
 1.21A 1u18B-2invA:
undetectable		 1u18B-2invA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 2inv INSULIN
FRUCTOTRANSFERASE
(Bacillus
sp.
snu-7) 		5 / 12 THR A 216
ILE A 215
ASN A 210
PHE A 183
MET A 218
 None
 1.32A 1wsvA-2invA:
undetectable		 1wsvA-2invA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 2inv INSULIN
FRUCTOTRANSFERASE
(Bacillus
sp.
snu-7) 		5 / 12 THR A 216
ILE A 215
ASN A 210
PHE A 183
MET A 218
 None
 1.26A 1wsvB-2invA:
undetectable		 1wsvB-2invA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_2
(HIV-1 PROTEASE)		 2inv INSULIN
FRUCTOTRANSFERASE
(Bacillus
sp.
snu-7) 		5 / 12 ASP A  73
GLY A  75
ALA A  76
ASP A  80
VAL A  68
 None
 1.08A 2b7zB-2invA:
undetectable		 2b7zB-2invA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2inv INSULIN
FRUCTOTRANSFERASE
(Bacillus
sp.
snu-7) 		5 / 11 ILE A  81
ALA A  99
ILE A 153
ILE A  78
THR A  54
 None
 1.07A 2blaA-2invA:
undetectable		 2blaA-2invA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2inv INSULIN
FRUCTOTRANSFERASE
(Bacillus
sp.
snu-7) 		3 / 3 ILE A 122
ILE A 153
LEU A 235
 None
 0.53A 2prgA-2invA:
undetectable		 2prgA-2invA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 2inv INSULIN
FRUCTOTRANSFERASE
(Bacillus
sp.
snu-7) 		4 / 7 ILE A 100
PHE A 165
ILE A 204
PHE A 183
 None
 1.15A 2qb4A-2invA:
undetectable		 2qb4A-2invA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 2inv INSULIN
FRUCTOTRANSFERASE
(Bacillus
sp.
snu-7) 		5 / 11 LEU A 235
VAL A 237
LEU A 185
VAL A 249
ILE A 242
 None
 0.98A 2uxoB-2invA:
undetectable		 2uxoB-2invA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 2inv INSULIN
FRUCTOTRANSFERASE
(Bacillus
sp.
snu-7) 		5 / 12 ILE A 297
ASN A 334
LEU A 312
VAL A 307
VAL A 360
 None
 1.13A 2vn0A-2invA:
0.0		 2vn0A-2invA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 2inv INSULIN
FRUCTOTRANSFERASE
(Bacillus
sp.
snu-7) 		5 / 12 LEU A 185
ILE A 102
ILE A 153
ILE A  82
PHE A 165
 None
 1.03A 2ygoA-2invA:
undetectable		 2ygoA-2invA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2inv INSULIN
FRUCTOTRANSFERASE
(Bacillus
sp.
snu-7) 		5 / 12 ALA A  76
ASP A  73
LEU A 109
ARG A 154
ILE A 102
 None
 1.16A 3k2hA-2invA:
undetectable		 3k2hA-2invA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2inv INSULIN
FRUCTOTRANSFERASE
(Bacillus
sp.
snu-7) 		5 / 10 ILE A  81
ALA A  99
ILE A 153
ILE A  78
THR A  54
 None
 1.18A 3qgtA-2invA:
undetectable		 3qgtA-2invA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2inv INSULIN
FRUCTOTRANSFERASE
(Bacillus
sp.
snu-7) 		5 / 10 ILE A  81
ALA A  99
ILE A 153
ILE A  78
THR A  54
 None
 1.15A 3qgtB-2invA:
undetectable		 3qgtB-2invA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_F_CAMF502_0
(CAMPHOR
5-MONOOXYGENASE)		 2inv INSULIN
FRUCTOTRANSFERASE
(Bacillus
sp.
snu-7) 		4 / 4 TYR A 107
THR A  59
VAL A  77
ILE A 102
 None
 1.33A 4jx1F-2invA:
undetectable		 4jx1F-2invA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 2inv INSULIN
FRUCTOTRANSFERASE
(Bacillus
sp.
snu-7) 		4 / 6 SER A 133
GLY A 271
ASP A 270
GLY A 293
 FRU  A   1 (-2.7A)
None
None
None
 1.03A 4koeA-2invA:
undetectable
4koeB-2invA:
undetectable
4koeC-2invA:
undetectable		 4koeA-2invA:
20.73
4koeB-2invA:
20.73
4koeC-2invA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2inv INSULIN
FRUCTOTRANSFERASE
(Bacillus
sp.
snu-7) 		5 / 12 LEU A 185
PHE A 165
ILE A 102
ILE A  78
THR A 157
 None
 1.08A 4pstA-2invA:
undetectable		 4pstA-2invA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2inv INSULIN
FRUCTOTRANSFERASE
(Bacillus
sp.
snu-7) 		4 / 7 VAL A 113
ILE A 102
ALA A  70
ILE A 101
 None
 0.77A 4uxqA-2invA:
undetectable		 4uxqA-2invA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 2inv INSULIN
FRUCTOTRANSFERASE
(Bacillus
sp.
snu-7) 		5 / 12 GLY A 217
ASP A 182
PHE A 165
PHE A 180
HIS A 214
 None
2PO  A1002 (-4.3A)
None
None
None
 1.17A 4wh5A-2invA:
undetectable		 4wh5A-2invA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2inv INSULIN
FRUCTOTRANSFERASE
(Bacillus
sp.
snu-7) 		4 / 6 SER A 133
GLY A 271
ASP A 270
GLY A 293
 FRU  A   1 (-2.7A)
None
None
None
 0.88A 5cdnA-2invA:
undetectable
5cdnB-2invA:
undetectable		 5cdnA-2invA:
22.49
5cdnB-2invA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2inv INSULIN
FRUCTOTRANSFERASE
(Bacillus
sp.
snu-7) 		4 / 6 SER A 133
GLY A 271
ASP A 270
GLY A 293
 FRU  A   1 (-2.7A)
None
None
None
 0.89A 5cdnR-2invA:
undetectable
5cdnS-2invA:
undetectable		 5cdnR-2invA:
22.49
5cdnS-2invA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2inv INSULIN
FRUCTOTRANSFERASE
(Bacillus
sp.
snu-7) 		4 / 5 LEU A 109
PHE A 183
ILE A  78
ILE A 122
 None
 1.01A 5dzk4-2invA:
undetectable
5dzkg-2invA:
2.2
5dzkm-2invA:
undetectable
5dzkn-2invA:
undetectable		 5dzk4-2invA:
0.85
5dzkg-2invA:
21.98
5dzkm-2invA:
19.26
5dzkn-2invA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2inv INSULIN
FRUCTOTRANSFERASE
(Bacillus
sp.
snu-7) 		4 / 5 PHE A 220
ILE A 215
GLY A 219
ILE A 204
 None
 0.93A 5dzkd-2invA:
2.2
5dzkk-2invA:
undetectable
5dzky-2invA:
undetectable		 5dzkd-2invA:
21.98
5dzkk-2invA:
19.26
5dzky-2invA:
0.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2inv INSULIN
FRUCTOTRANSFERASE
(Bacillus
sp.
snu-7) 		5 / 12 ALA A 276
LEU A 274
PHE A 183
ILE A 153
PHE A 180
 None
 1.04A 5eshA-2invA:
undetectable		 5eshA-2invA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2inv INSULIN
FRUCTOTRANSFERASE
(Bacillus
sp.
snu-7) 		4 / 8 VAL A 113
ILE A 122
ILE A 100
SER A  72
 None
 0.67A 5numA-2invA:
undetectable		 5numA-2invA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2inv INSULIN
FRUCTOTRANSFERASE
(Bacillus
sp.
snu-7) 		4 / 8 VAL A 113
ILE A 122
ILE A 102
SER A  72
 None
 0.64A 5numA-2invA:
undetectable		 5numA-2invA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 2inv INSULIN
FRUCTOTRANSFERASE
(Bacillus
sp.
snu-7) 		4 / 6 ASN A 334
THR A 308
ASN A 310
ILE A 297
 None
 1.27A 5uigA-2invA:
undetectable		 5uigA-2invA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2inv INSULIN
FRUCTOTRANSFERASE
(Bacillus
sp.
snu-7) 		4 / 6 LEU A 227
VAL A 229
LEU A 235
VAL A 206
 None
 0.84A 5x7zA-2invA:
undetectable		 5x7zA-2invA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 2inv INSULIN
FRUCTOTRANSFERASE
(Bacillus
sp.
snu-7) 		4 / 6 GLY A 266
GLY A 268
PRO A 269
GLY A 271
 FRU  A   1 ( 4.1A)
None
None
None
 0.68A 6ag0C-2invA:
undetectable		 6ag0C-2invA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2inv INSULIN
FRUCTOTRANSFERASE
(Bacillus
sp.
snu-7) 		4 / 6 GLY A 231
ASN A 210
ASP A 209
ARG A 230
 None
 1.16A 6dwdA-2invA:
undetectable
6dwdC-2invA:
undetectable		 6dwdA-2invA:
21.97
6dwdC-2invA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2inv INSULIN
FRUCTOTRANSFERASE
(Bacillus
sp.
snu-7) 		4 / 5 GLY A 231
ASN A 210
ASP A 209
ARG A 230
 None
 1.16A 6dwdB-2invA:
undetectable
6dwdD-2invA:
undetectable		 6dwdB-2invA:
21.97
6dwdD-2invA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 2inv INSULIN
FRUCTOTRANSFERASE
(Bacillus
sp.
snu-7) 		5 / 10 ARG A 294
LEU A 353
GLY A 268
GLY A 348
ARG A 349
 None
 1.17A 6eu9B-2invA:
undetectable		 6eu9B-2invA:
10.43