SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2io1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2io1 SMALL
UBIQUITIN-RELATED
MODIFIER 3 PRECURSOR
(Homo
sapiens) 		5 / 10 LEU B  75
ILE B  33
ASP B  81
LEU B  19
ILE B  17
 None
 0.71A 1yi4A-2io1B:
undetectable		 1yi4A-2io1B:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 2io1 SMALL
UBIQUITIN-RELATED
MODIFIER 3 PRECURSOR
(Homo
sapiens) 		4 / 8 PRO B  72
ASN B  67
GLN B  64
ILE B  83
 None
 0.97A 4iilA-2io1B:
undetectable		 4iilA-2io1B:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 2io1 SMALL
UBIQUITIN-RELATED
MODIFIER 3 PRECURSOR
(Homo
sapiens) 		3 / 3 GLU B  80
LYS B  20
ASN B  18
 None
 0.67A 4y1dA-2io1B:
undetectable
4y1dD-2io1B:
undetectable		 4y1dA-2io1B:
21.97
4y1dD-2io1B:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2io1 SMALL
UBIQUITIN-RELATED
MODIFIER 3 PRECURSOR
(Homo
sapiens) 		3 / 3 LYS B  41
LEU B  19
ILE B  66
 None
 0.82A 5kc4A-2io1B:
undetectable		 5kc4A-2io1B:
18.29