SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iod'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2iod DIHYDROFLAVONOL
4-REDUCTASE
(Vitis
vinifera) 		4 / 7 ILE A 213
PRO A 212
PHE A 280
ALA A 264
 None
 1.12A 1oniG-2iodA:
undetectable
1oniI-2iodA:
undetectable		 1oniG-2iodA:
16.08
1oniI-2iodA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 2iod DIHYDROFLAVONOL
4-REDUCTASE
(Vitis
vinifera) 		4 / 7 PHE A 312
GLY A 314
THR A 318
ILE A 198
 None
 0.95A 2bdmA-2iodA:
undetectable		 2bdmA-2iodA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 2iod DIHYDROFLAVONOL
4-REDUCTASE
(Vitis
vinifera) 		3 / 3 ARG A 154
THR A 168
VAL A 165
 None
 0.92A 2q64A-2iodA:
undetectable		 2q64A-2iodA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XPV_A_MIYA1209_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 2iod DIHYDROFLAVONOL
4-REDUCTASE
(Vitis
vinifera) 		5 / 12 SER A 128
THR A 131
VAL A 132
ILE A 252
SER A 254
 MYC  A1342 ( 2.2A)
None
None
None
None
 1.35A 2xpvA-2iodA:
undetectable		 2xpvA-2iodA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLG_A_ASCA130_0
(CYTOCHROME C')		 2iod DIHYDROFLAVONOL
4-REDUCTASE
(Vitis
vinifera) 		4 / 5 ALA A  74
GLY A  80
CYH A  78
LYS A   6
 None
 1.49A 2ylgA-2iodA:
undetectable		 2ylgA-2iodA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2iod DIHYDROFLAVONOL
4-REDUCTASE
(Vitis
vinifera) 		4 / 8 SER A 205
VAL A 193
LEU A 231
ALA A 315
 NAP  A1340 ( 3.0A)
NAP  A1340 (-3.9A)
None
None
 0.88A 3ax7A-2iodA:
undetectable		 3ax7A-2iodA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2iod DIHYDROFLAVONOL
4-REDUCTASE
(Vitis
vinifera) 		5 / 9 LEU A 308
PHE A 228
VAL A 194
ILE A 223
ALA A 209
 None
 1.14A 3mdvA-2iodA:
undetectable		 3mdvA-2iodA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)		 2iod DIHYDROFLAVONOL
4-REDUCTASE
(Vitis
vinifera) 		5 / 8 GLY A  69
ASP A  67
ASP A  64
GLY A 106
THR A  11
 None
None
NAP  A1340 (-3.6A)
None
None
 1.45A 3so9A-2iodA:
undetectable		 3so9A-2iodA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2iod DIHYDROFLAVONOL
4-REDUCTASE
(Vitis
vinifera) 		4 / 7 VAL A  10
VAL A  32
LEU A  58
ASN A 236
 None
 0.92A 4e1gB-2iodA:
undetectable		 4e1gB-2iodA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 2iod DIHYDROFLAVONOL
4-REDUCTASE
(Vitis
vinifera) 		5 / 12 ILE A 188
LEU A 297
GLY A 249
ILE A 186
ASN A 182
 None
 1.15A 4o1eA-2iodA:
undetectable		 4o1eA-2iodA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 2iod DIHYDROFLAVONOL
4-REDUCTASE
(Vitis
vinifera) 		5 / 12 ILE A 188
LEU A 297
GLY A 249
ILE A 186
ASN A 182
 None
 1.19A 4o1eB-2iodA:
undetectable		 4o1eB-2iodA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 2iod DIHYDROFLAVONOL
4-REDUCTASE
(Vitis
vinifera) 		4 / 7 GLU A 171
SER A 127
ILE A 189
VAL A 132
 None
 1.22A 4tvtA-2iodA:
undetectable		 4tvtA-2iodA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_D_ACTD403_0
(PROTON-GATED ION
CHANNEL)		 2iod DIHYDROFLAVONOL
4-REDUCTASE
(Vitis
vinifera) 		4 / 4 ILE A 239
ARG A 121
TYR A  30
GLU A   6
 None
 1.27A 4zzbD-2iodA:
undetectable		 4zzbD-2iodA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2iod DIHYDROFLAVONOL
4-REDUCTASE
(Vitis
vinifera) 		5 / 12 LEU A 123
ALA A 170
SER A 166
PRO A  87
LEU A  65
 None
None
None
NAP  A1340 ( 4.3A)
NAP  A1340 (-3.7A)
 1.34A 5syfB-2iodA:
5.7		 5syfB-2iodA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2iod DIHYDROFLAVONOL
4-REDUCTASE
(Vitis
vinifera) 		5 / 12 LEU A 231
SER A 200
ILE A 198
HIS A  47
THR A 318
 None
 1.21A 6djzB-2iodA:
undetectable		 6djzB-2iodA:
18.75