SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iop'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 8 LEU A 324
TYR A 279
GLY A 296
TYR A 300
 None
 1.06A 1jlfA-2iopA:
undetectable
1jlfB-2iopA:
undetectable		 1jlfA-2iopA:
21.90
1jlfB-2iopA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 8 GLU A 361
SER A 415
ASP A 418
GLU A 394
 None
 1.13A 1knyA-2iopA:
undetectable
1knyB-2iopA:
undetectable		 1knyA-2iopA:
17.17
1knyB-2iopA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 7 LEU A 324
TYR A 279
GLY A 296
TYR A 300
 None
 1.00A 1lweA-2iopA:
undetectable		 1lweA-2iopA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		5 / 12 ASN A  38
ASP A  41
ASP A  80
MET A  85
THR A 174
 ADP  A1001 (-3.9A)
None
ADP  A1001 (-3.9A)
ADP  A1001 (-3.7A)
ADP  A1001 (-3.4A)
 0.82A 1s14A-2iopA:
10.1		 1s14A-2iopA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		5 / 12 LEU A 357
LEU A 360
LEU A 363
ALA A 364
LEU A 400
 None
 0.77A 1ya3C-2iopA:
undetectable		 1ya3C-2iopA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 5 LEU A 348
LEU A 299
LEU A 324
LEU A 330
 None
 0.86A 1yajD-2iopA:
undetectable		 1yajD-2iopA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXD_A_RWFA2001_1
(SERUM ALBUMIN)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		5 / 9 TYR A 371
PHE A 320
LEU A 382
ARG A 401
LEU A 400
 None
 0.94A 2bxdA-2iopA:
0.5		 2bxdA-2iopA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		5 / 12 LEU A 330
ALA A 310
MET A 307
SER A 335
LEU A 339
 None
 1.19A 2c12C-2iopA:
undetectable		 2c12C-2iopA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 7 LEU A 382
PHE A 378
PHE A 374
LEU A 360
 None
 0.98A 2eikC-2iopA:
undetectable
2eikJ-2iopA:
undetectable		 2eikC-2iopA:
16.83
2eikJ-2iopA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 8 LEU A 382
PHE A 378
PHE A 374
LEU A 360
 None
 0.99A 2eilP-2iopA:
undetectable
2eilW-2iopA:
undetectable		 2eilP-2iopA:
16.83
2eilW-2iopA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 7 LEU A 178
ILE A 176
ASN A  38
PHE A 127
 None
None
ADP  A1001 (-3.9A)
None
 0.89A 2opxA-2iopA:
undetectable		 2opxA-2iopA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 4 SER A 156
GLY A 158
HIS A  93
ASP A  41
 None
None
ADP  A1001 (-3.7A)
None
 1.21A 2oxtC-2iopA:
undetectable		 2oxtC-2iopA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 7 LEU A 601
LEU A 608
LEU A 597
GLU A 594
 None
 0.86A 2vq5B-2iopA:
undetectable		 2vq5B-2iopA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 6 LEU A 382
PHE A 378
PHE A 374
LEU A 360
 None
 1.00A 3abkP-2iopA:
undetectable
3abkW-2iopA:
undetectable		 3abkP-2iopA:
16.83
3abkW-2iopA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 7 LEU A 382
PHE A 378
PHE A 374
LEU A 360
 None
 0.94A 3ag2P-2iopA:
undetectable
3ag2W-2iopA:
undetectable		 3ag2P-2iopA:
16.83
3ag2W-2iopA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 8 LEU A 382
PHE A 378
PHE A 374
LEU A 360
 None
 0.97A 3asoC-2iopA:
undetectable
3asoJ-2iopA:
undetectable		 3asoC-2iopA:
16.83
3asoJ-2iopA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 7 ASP A 462
SER A 461
SER A 404
ASP A 418
 None
 1.12A 3bc9A-2iopA:
undetectable		 3bc9A-2iopA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		3 / 3 SER A 100
GLY A 124
GLY A 126
 None
None
ADP  A1001 (-3.3A)
 0.53A 3bogA-2iopA:
undetectable
3bogC-2iopA:
undetectable		 3bogA-2iopA:
undetectable
3bogC-2iopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 6 GLN A 358
LEU A 360
GLU A 361
LEU A 399
 None
 0.90A 3h5gA-2iopA:
undetectable
3h5gC-2iopA:
undetectable		 3h5gA-2iopA:
4.28
3h5gC-2iopA:
4.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 5 LEU A 399
GLN A 358
LEU A 360
GLU A 361
 None
 1.05A 3h5gA-2iopA:
undetectable
3h5gB-2iopA:
undetectable		 3h5gA-2iopA:
4.28
3h5gB-2iopA:
4.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		3 / 3 GLU A 384
GLU A 388
TRP A 467
 None
 1.05A 3hrdA-2iopA:
undetectable
3hrdE-2iopA:
1.4
3hrdF-2iopA:
undetectable		 3hrdA-2iopA:
21.91
3hrdE-2iopA:
21.91
3hrdF-2iopA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 6 ARG A  33
SER A  37
GLY A 124
GLU A 107
 None
 0.99A 3k9fA-2iopA:
undetectable
3k9fB-2iopA:
undetectable
3k9fD-2iopA:
undetectable		 3k9fA-2iopA:
23.02
3k9fB-2iopA:
23.02
3k9fD-2iopA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		5 / 12 ASN A  38
ASP A  41
ASP A  80
MET A  85
THR A 174
 ADP  A1001 (-3.9A)
None
ADP  A1001 (-3.9A)
ADP  A1001 (-3.7A)
ADP  A1001 (-3.4A)
 0.71A 3lpsA-2iopA:
10.7		 3lpsA-2iopA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 8 SER A  37
ARG A  33
ASN A  38
ASP A  41
 None
None
ADP  A1001 (-3.9A)
None
 0.93A 3n62B-2iopA:
undetectable		 3n62B-2iopA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		3 / 3 ASN A 228
ALA A 230
ARG A 303
 None
 0.88A 3tj7C-2iopA:
undetectable
3tj7D-2iopA:
undetectable		 3tj7C-2iopA:
14.94
3tj7D-2iopA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		5 / 10 SER A 590
LEU A 519
VAL A 523
PHE A 568
VAL A 515
 None
 1.41A 3u9fK-2iopA:
undetectable		 3u9fK-2iopA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		5 / 11 SER A 590
LEU A 519
VAL A 523
PHE A 568
VAL A 515
 None
 1.49A 3u9fN-2iopA:
undetectable
3u9fO-2iopA:
undetectable		 3u9fN-2iopA:
15.25
3u9fO-2iopA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		5 / 10 SER A 590
LEU A 519
VAL A 523
PHE A 568
VAL A 515
 None
 1.48A 3u9fR-2iopA:
undetectable		 3u9fR-2iopA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 8 LEU A 597
VAL A 526
TYR A 566
LEU A 601
 None
 1.10A 3v81A-2iopA:
undetectable		 3v81A-2iopA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 6 LEU A 382
PHE A 378
PHE A 374
LEU A 360
 None
 0.94A 3wg7C-2iopA:
undetectable
3wg7J-2iopA:
undetectable		 3wg7C-2iopA:
16.83
3wg7J-2iopA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 6 LEU A 382
PHE A 378
PHE A 374
LEU A 360
 None
 0.96A 3wg7P-2iopA:
undetectable
3wg7W-2iopA:
undetectable		 3wg7P-2iopA:
16.83
3wg7W-2iopA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 7 LEU A 382
PHE A 378
PHE A 374
LEU A 360
 None
 0.93A 3x2qC-2iopA:
undetectable
3x2qJ-2iopA:
undetectable		 3x2qC-2iopA:
16.83
3x2qJ-2iopA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 7 ARG A  33
ILE A 204
ASN A  38
ASP A  41
 None
None
ADP  A1001 (-3.9A)
None
 1.03A 4d33B-2iopA:
undetectable		 4d33B-2iopA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 8 ARG A  33
ILE A 204
ASN A  38
ASP A  41
 None
None
ADP  A1001 (-3.9A)
None
 1.06A 4d39A-2iopA:
undetectable		 4d39A-2iopA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 7 ARG A  33
ILE A 204
ASN A  38
ASP A  41
 None
None
ADP  A1001 (-3.9A)
None
 1.06A 4d39B-2iopA:
undetectable		 4d39B-2iopA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		5 / 9 THR A 345
GLN A 340
LEU A 339
VAL A 334
LEU A 299
 None
 1.19A 4g1bC-2iopA:
undetectable		 4g1bC-2iopA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		5 / 11 ASN A  38
ASP A  41
ASP A  80
MET A  85
THR A 174
 ADP  A1001 (-3.9A)
None
ADP  A1001 (-3.9A)
ADP  A1001 (-3.7A)
ADP  A1001 (-3.4A)
 0.64A 4urnA-2iopA:
11.4		 4urnA-2iopA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		5 / 11 ASN A  38
ASP A  41
ASP A  80
MET A  85
THR A 174
 ADP  A1001 (-3.9A)
None
ADP  A1001 (-3.9A)
ADP  A1001 (-3.7A)
ADP  A1001 (-3.4A)
 0.73A 4urnB-2iopA:
10.9		 4urnB-2iopA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		5 / 11 ASN A  38
ASP A  41
ASP A  80
MET A  85
THR A 174
 ADP  A1001 (-3.9A)
None
ADP  A1001 (-3.9A)
ADP  A1001 (-3.7A)
ADP  A1001 (-3.4A)
 0.73A 4urnC-2iopA:
11.1		 4urnC-2iopA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		5 / 10 ALA A  50
GLY A  61
LEU A  63
ALA A  43
ASP A  44
 None
 1.27A 5ajqB-2iopA:
undetectable		 5ajqB-2iopA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 7 LEU A 382
PHE A 378
PHE A 374
LEU A 360
 None
 0.93A 5b1aC-2iopA:
undetectable
5b1aJ-2iopA:
undetectable		 5b1aC-2iopA:
16.83
5b1aJ-2iopA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 7 LEU A 382
PHE A 378
PHE A 374
LEU A 360
 None
 0.89A 5b1aP-2iopA:
undetectable
5b1aW-2iopA:
undetectable		 5b1aP-2iopA:
16.83
5b1aW-2iopA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 7 LEU A 382
PHE A 378
PHE A 374
LEU A 360
 None
 0.92A 5b3sC-2iopA:
undetectable
5b3sJ-2iopA:
undetectable		 5b3sC-2iopA:
16.83
5b3sJ-2iopA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 7 LEU A 382
PHE A 378
PHE A 374
LEU A 360
 None
 0.89A 5b3sP-2iopA:
undetectable		 5b3sP-2iopA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		3 / 3 THR A 168
ASP A 171
GLU A 175
 None
 0.82A 5fa8A-2iopA:
undetectable		 5fa8A-2iopA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		5 / 12 PHE A 320
ILE A 280
LEU A 318
LEU A 357
PHE A 374
 None
 1.24A 5im2A-2iopA:
undetectable		 5im2A-2iopA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		5 / 10 LEU A 382
VAL A 381
LEU A 360
VAL A 321
ILE A 280
 None
 1.09A 5v02B-2iopA:
undetectable
5v02R-2iopA:
undetectable		 5v02B-2iopA:
10.74
5v02R-2iopA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 5 LEU A 382
PHE A 378
PHE A 374
LEU A 360
 None
 1.00A 5x1bP-2iopA:
undetectable		 5x1bP-2iopA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 5 LEU A 601
PHE A 614
LEU A 597
PHE A 568
 None
 1.24A 5xdxC-2iopA:
undetectable
5xdxJ-2iopA:
undetectable		 5xdxC-2iopA:
16.67
5xdxJ-2iopA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 5 LEU A 601
PHE A 614
LEU A 597
PHE A 568
 None
 1.27A 5xdxP-2iopA:
undetectable
5xdxW-2iopA:
undetectable		 5xdxP-2iopA:
16.67
5xdxW-2iopA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2iop CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 7 LEU A 382
PHE A 378
PHE A 374
LEU A 360
 None
 0.92A 5zcqP-2iopA:
undetectable
5zcqW-2iopA:
undetectable		 5zcqP-2iopA:
16.83
5zcqW-2iopA:
8.76