SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ior'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 2ior CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 4 GLY A  82
LEU A  46
GLY A 173
ARG A 172
 None
 1.42A 1j7kA-2iorA:
undetectable		 1j7kA-2iorA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 2ior CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 7 LEU A 178
ILE A 176
ASN A  38
PHE A 127
 None
None
MG  A2000 ( 2.6A)
None
 0.83A 2opxA-2iorA:
undetectable		 2opxA-2iorA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2ior CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 6 ILE A 197
ARG A  66
THR A  77
LEU A  76
 None
 1.02A 3ag1N-2iorA:
undetectable
3ag1W-2iorA:
undetectable		 3ag1N-2iorA:
17.85
3ag1W-2iorA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 2ior CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 7 LEU A 119
GLN A 122
PHE A 105
LEU A 109
 None
 1.01A 3ag2C-2iorA:
undetectable		 3ag2C-2iorA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2ior CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 8 LEU A 119
GLN A 122
PHE A 105
LEU A 109
 None
 0.99A 3asoC-2iorA:
undetectable
3asoJ-2iorA:
undetectable		 3asoC-2iorA:
21.32
3asoJ-2iorA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 2ior CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		5 / 12 ARG A 142
GLY A  82
GLY A  84
SER A  40
GLU A  58
 None
None
ADP  A1000 ( 4.4A)
None
None
 1.15A 3kkzA-2iorA:
undetectable		 3kkzA-2iorA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 2ior CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		5 / 12 ARG A 142
GLY A  82
GLY A  84
SER A  40
GLU A  58
 None
None
ADP  A1000 ( 4.4A)
None
None
 1.16A 3sxjA-2iorA:
undetectable		 3sxjA-2iorA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 2ior CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		5 / 12 ARG A 142
GLY A  82
GLY A  84
SER A  40
GLU A  58
 None
None
ADP  A1000 ( 4.4A)
None
None
 1.16A 3sxjB-2iorA:
undetectable		 3sxjB-2iorA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)		 2ior CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		5 / 12 ARG A 142
GLY A  82
GLY A  84
SER A  40
GLU A  58
 None
None
ADP  A1000 ( 4.4A)
None
None
 1.21A 3t7sA-2iorA:
undetectable		 3t7sA-2iorA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 2ior CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		5 / 12 ARG A 142
GLY A  82
GLY A  84
SER A  40
GLU A  58
 None
None
ADP  A1000 ( 4.4A)
None
None
 1.13A 3t7sB-2iorA:
undetectable		 3t7sB-2iorA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 2ior CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		5 / 12 ARG A 142
GLY A  82
GLY A  84
SER A  40
GLU A  58
 None
None
ADP  A1000 ( 4.4A)
None
None
 1.16A 3t7sC-2iorA:
undetectable		 3t7sC-2iorA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 2ior CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		5 / 12 ARG A 142
GLY A  82
GLY A  84
SER A  40
GLU A  58
 None
None
ADP  A1000 ( 4.4A)
None
None
 1.13A 3t7sD-2iorA:
undetectable		 3t7sD-2iorA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2ior CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		5 / 10 ALA A  50
GLY A  61
LEU A  63
ALA A  43
ASP A  44
 None
 1.28A 5ajqB-2iorA:
undetectable		 5ajqB-2iorA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA820_0
(GEPHYRIN)		 2ior CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 5 GLU A 155
THR A 163
GLN A   4
MET A   1
 None
 0.94A 6fgdA-2iorA:
undetectable		 6fgdA-2iorA:
19.86