SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iou'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2iou MAJOR TROPISM
DETERMINANT P1
(Bordetella
virus
BPP1) 		4 / 7 GLY A 373
ALA A 176
HIS A 200
THR A 205
 None
 0.87A 1c9sT-2iouA:
undetectable
1c9sU-2iouA:
undetectable		 1c9sT-2iouA:
12.77
1c9sU-2iouA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		4 / 5 ARG G 320
ALA G 317
ASP G 297
GLY G 295
 None
 1.04A 1e7bA-2iouG:
undetectable		 1e7bA-2iouG:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		4 / 5 ARG G 320
ALA G 317
ASP G 297
GLY G 295
 None
 1.01A 1e7cA-2iouG:
undetectable		 1e7cA-2iouG:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2iou MAJOR TROPISM
DETERMINANT P1
(Bordetella
virus
BPP1) 		4 / 8 SER A 271
VAL A 276
GLY A 285
GLY A 273
 None
 0.79A 1f5lA-2iouA:
undetectable		 1f5lA-2iouA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2iou MAJOR TROPISM
DETERMINANT P1
(Bordetella
virus
BPP1) 		4 / 7 GLY A 373
ALA A 176
HIS A 200
THR A 205
 None
 0.84A 1gtfL-2iouA:
undetectable
1gtfM-2iouA:
undetectable		 1gtfL-2iouA:
12.77
1gtfM-2iouA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2iou MAJOR TROPISM
DETERMINANT P1
(Bordetella
virus
BPP1) 		4 / 8 GLY A 373
ALA A 176
HIS A 200
THR A 205
 None
 0.86A 1gtfN-2iouA:
undetectable
1gtfO-2iouA:
undetectable		 1gtfN-2iouA:
12.77
1gtfO-2iouA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_A_BEZA1501_0
(ANTHRANILATE
SYNTHASE)		 2iou MAJOR TROPISM
DETERMINANT P1
(Bordetella
virus
BPP1) 		5 / 11 GLY A 204
THR A 205
HIS A 248
GLY A 181
LYS A 250
 None
 1.35A 1i7qA-2iouA:
undetectable		 1i7qA-2iouA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_C_BEZC1502_0
(ANTHRANILATE
SYNTHASE)		 2iou MAJOR TROPISM
DETERMINANT P1
(Bordetella
virus
BPP1) 		5 / 10 GLY A 204
THR A 205
HIS A 248
GLY A 181
LYS A 250
 None
 1.35A 1i7qC-2iouA:
undetectable		 1i7qC-2iouA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		4 / 8 VAL G 246
VAL G 296
ILE G 360
LEU G 305
 None
 0.91A 1igxA-2iouG:
undetectable		 1igxA-2iouG:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		5 / 12 ARG G 484
PHE G 483
LEU G 526
LEU G 539
LEU G 452
 None
 1.23A 1og5A-2iouG:
undetectable		 1og5A-2iouG:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		5 / 12 ILE G 238
ALA G 221
ILE G 319
LEU G 305
ILE G 261
 None
 0.98A 1rx7A-2iouG:
undetectable		 1rx7A-2iouG:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TNL_A_TPAA900_1
(TRYPSIN)		 2iou MAJOR TROPISM
DETERMINANT P1
(Bordetella
virus
BPP1) 		4 / 6 SER A 271
VAL A 276
GLY A 285
GLY A 273
 None
 0.74A 1tnlA-2iouA:
undetectable		 1tnlA-2iouA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 2iou MAJOR TROPISM
DETERMINANT P1
(Bordetella
virus
BPP1) 		5 / 12 SER A 288
GLY A 155
PHE A 293
ALA A 152
ALA A 154
 None
 1.09A 2avdB-2iouA:
undetectable		 2avdB-2iouA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		6 / 12 LEU G 231
LEU G 256
GLY G 245
SER G 217
ALA G 222
ALA G 213
 None
 1.49A 2br4C-2iouG:
undetectable		 2br4C-2iouG:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		5 / 12 ILE G 238
ALA G 221
ILE G 319
LEU G 305
ILE G 261
 None
 0.95A 2d0kA-2iouG:
undetectable		 2d0kA-2iouG:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		5 / 12 SER G 100
THR G 115
VAL G 116
LEU G  91
ILE G  54
 None
 1.47A 2fj1A-2iouG:
undetectable		 2fj1A-2iouG:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 2iou MAJOR TROPISM
DETERMINANT P1
(Bordetella
virus
BPP1) 		5 / 11 GLY A 204
THR A 205
HIS A 248
GLY A 181
LYS A 250
 None
 1.43A 2fn1A-2iouA:
undetectable		 2fn1A-2iouA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)		 2iou MAJOR TROPISM
DETERMINANT P1
(Bordetella
virus
BPP1) 		5 / 11 GLY A 204
THR A 205
HIS A 248
GLY A 181
LYS A 250
 None
 1.40A 2fn1B-2iouA:
undetectable		 2fn1B-2iouA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 2iou MAJOR TROPISM
DETERMINANT P1
(Bordetella
virus
BPP1) 		4 / 6 SER A 271
VAL A 276
GLY A 285
GLY A 273
 None
 0.76A 2otvA-2iouA:
undetectable		 2otvA-2iouA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 2iou MAJOR TROPISM
DETERMINANT P1
(Bordetella
virus
BPP1) 		5 / 12 ASP A 275
ILE A 212
ASP A 214
GLY A 370
SER A 351
 None
 1.40A 2pgfA-2iouA:
undetectable		 2pgfA-2iouA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		3 / 3 SER G 480
ASP G 435
ASP G 455
 None
 0.60A 2plwA-2iouG:
undetectable		 2plwA-2iouG:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		3 / 3 PRO G 463
ASN G 486
ARG G 512
 None
 0.93A 2qeuB-2iouG:
undetectable		 2qeuB-2iouG:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		5 / 12 ALA G 219
THR G 136
ALA G 163
ASP G 183
ARG G 167
 None
 1.34A 2qm9A-2iouG:
undetectable		 2qm9A-2iouG:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUJ_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		4 / 8 VAL G 223
VAL G 303
LEU G 305
VAL G 254
 None
 0.84A 2zujA-2iouG:
undetectable		 2zujA-2iouG:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		5 / 8 VAL G  98
GLY G 114
THR G 115
GLY G 165
ALA G 143
 None
 1.24A 3aruA-2iouG:
undetectable		 3aruA-2iouG:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		5 / 12 ALA G 387
GLN G 363
ILE G 360
VAL G 429
LEU G 373
 None
 1.00A 3dzuA-2iouG:
undetectable		 3dzuA-2iouG:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		5 / 10 ILE G 434
SER G 454
SER G 480
GLY G 456
LEU G 450
 None
 1.30A 3ik6B-2iouG:
undetectable
3ik6E-2iouG:
undetectable		 3ik6B-2iouG:
15.91
3ik6E-2iouG:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		3 / 3 SER G 299
ASP G 297
ASP G 250
 None
 0.83A 3iv6A-2iouG:
undetectable		 3iv6A-2iouG:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		4 / 6 VAL G 341
VAL G 296
ILE G 360
ARG G 367
 None
 1.07A 3ms9A-2iouG:
undetectable		 3ms9A-2iouG:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		4 / 6 VAL G 341
VAL G 296
ILE G 360
ARG G 367
 None
 1.05A 3mssA-2iouG:
undetectable		 3mssA-2iouG:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		4 / 6 VAL G 341
VAL G 296
ILE G 360
ARG G 367
 None
 1.06A 3mssC-2iouG:
undetectable		 3mssC-2iouG:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 2iou MAJOR TROPISM
DETERMINANT P1
(Bordetella
virus
BPP1) 		3 / 3 LYS A 138
ARG A 173
LYS A 207
 None
 1.43A 3okxA-2iouA:
undetectable		 3okxA-2iouA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 2iou MAJOR TROPISM
DETERMINANT P1
(Bordetella
virus
BPP1) 		4 / 6 SER A 271
VAL A 276
GLY A 285
GLY A 273
 None
 0.73A 3rxfA-2iouA:
undetectable		 3rxfA-2iouA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		5 / 11 ALA G 248
VAL G 254
VAL G 223
GLY G 245
LEU G 231
 None
 1.05A 3sm2B-2iouG:
undetectable		 3sm2B-2iouG:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		5 / 11 VAL G 176
VAL G 166
GLY G 185
ALA G 222
LEU G 206
 None
 1.05A 3sm2B-2iouG:
undetectable		 3sm2B-2iouG:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		5 / 11 VAL G 204
VAL G 166
GLY G 185
ALA G 222
LEU G 231
 None
 1.05A 3sm2B-2iouG:
undetectable		 3sm2B-2iouG:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		6 / 12 GLY G 164
VAL G 214
ASP G 183
GLY G 114
ALA G 143
ALA G 131
 None
 1.38A 3sudD-2iouG:
undetectable		 3sudD-2iouG:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_D_ACTD502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2iou MAJOR TROPISM
DETERMINANT P1
(Bordetella
virus
BPP1) 		3 / 3 GLY A 155
THR A 294
ASN A 291
 None
 0.66A 3v4tD-2iouA:
undetectable		 3v4tD-2iouA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		4 / 5 ARG G 376
VAL G 414
LEU G 432
SER G 431
 None
 1.30A 4e1gA-2iouG:
undetectable		 4e1gA-2iouG:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		4 / 8 GLY G 346
GLY G 322
VAL G 382
GLU G 380
 None
 0.84A 4fgzA-2iouG:
undetectable		 4fgzA-2iouG:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_A_STRA301_1
(STEROID RECEPTOR 2)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		5 / 12 LEU G 374
LEU G 373
ALA G 372
ALA G 317
THR G 399
 None
 1.12A 4fn9A-2iouG:
undetectable		 4fn9A-2iouG:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		5 / 11 THR G 129
ALA G 131
LEU G 130
THR G 115
VAL G 116
 None
 1.05A 4g1bB-2iouG:
undetectable		 4g1bB-2iouG:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2iou MAJOR TROPISM
DETERMINANT P1
(Bordetella
virus
BPP1) 		5 / 12 ALA A  75
ALA A 110
ILE A 111
LEU A 103
MET A 100
 None
 1.19A 4r38A-2iouA:
undetectable		 4r38A-2iouA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V30_B_LVYB151_1
(CEREBLON ISOFORM 4)		 2iou MAJOR TROPISM
DETERMINANT P1
(Bordetella
virus
BPP1) 		4 / 8 ASN A 291
PHE A 293
TRP A 290
TYR A 194
 None
 1.39A 4v30B-2iouA:
undetectable		 4v30B-2iouA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		4 / 7 THR G 129
ALA G 131
SER G 101
THR G  99
 None
 0.94A 5bojB-2iouG:
undetectable		 5bojB-2iouG:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2iou MAJOR TROPISM
DETERMINANT P1
(Bordetella
virus
BPP1) 		4 / 5 THR A  41
GLY A  43
GLU A  24
ASP A  38
 None
 0.98A 5c0oH-2iouA:
undetectable		 5c0oH-2iouA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2iou MAJOR TROPISM
DETERMINANT P1
(Bordetella
virus
BPP1) 		4 / 8 GLY A 373
ALA A 176
HIS A 200
THR A 205
 None
 0.86A 5eezL-2iouA:
undetectable
5eezV-2iouA:
undetectable		 5eezL-2iouA:
12.77
5eezV-2iouA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2iou MAJOR TROPISM
DETERMINANT P1
(Bordetella
virus
BPP1) 		4 / 8 GLY A 373
ALA A 176
HIS A 200
THR A 205
 None
 0.86A 5ef1L-2iouA:
undetectable
5ef1V-2iouA:
undetectable		 5ef1L-2iouA:
12.77
5ef1V-2iouA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2iou MAJOR TROPISM
DETERMINANT P1
(Bordetella
virus
BPP1) 		4 / 8 GLY A 373
ALA A 176
HIS A 200
THR A 205
 None
 0.86A 5ef2L-2iouA:
undetectable
5ef2V-2iouA:
undetectable		 5ef2L-2iouA:
12.77
5ef2V-2iouA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		5 / 12 ILE G 309
VAL G 310
GLY G 332
SER G 333
ARG G 258
 None
 0.99A 5ergB-2iouG:
undetectable		 5ergB-2iouG:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 2iou MAJOR TROPISM
DETERMINANT P1
(Bordetella
virus
BPP1) 		5 / 12 ALA A 262
GLY A 264
GLY A 298
GLY A 352
LEU A 195
 None
 1.00A 5gwxA-2iouA:
undetectable		 5gwxA-2iouA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		5 / 12 ASP G 297
ALA G 247
PHE G 226
GLY G 251
SER G 299
 None
 1.21A 5hfjD-2iouG:
undetectable		 5hfjD-2iouG:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		5 / 12 ASP G 297
ALA G 247
PHE G 226
GLY G 251
SER G 299
 None
 1.24A 5hfjH-2iouG:
undetectable		 5hfjH-2iouG:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2iou MAJOR TROPISM
DETERMINANT P1
(Bordetella
virus
BPP1) 		4 / 7 ILE A 212
GLY A 197
PHE A 341
ASP A 192
 None
 1.01A 5hieA-2iouA:
undetectable		 5hieA-2iouA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		3 / 3 LEU G 477
LEU G 497
ARG G 427
 None
 0.62A 5hnzB-2iouG:
undetectable		 5hnzB-2iouG:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		4 / 8 GLN G 363
ALA G 420
GLN G 419
SER G 418
 None
 0.92A 5km8A-2iouG:
undetectable
5km8B-2iouG:
undetectable		 5km8A-2iouG:
13.77
5km8B-2iouG:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_2
(PROTEASE E35D-APV)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		5 / 9 ASN G 340
GLY G 339
ASP G 395
VAL G 397
VAL G 377
 None
 0.95A 5kr0B-2iouG:
undetectable		 5kr0B-2iouG:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		5 / 8 VAL G 296
ILE G 261
ALA G 259
VAL G 254
VAL G 303
 None
 1.14A 5l94A-2iouG:
undetectable		 5l94A-2iouG:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_B_EF2B202_0
(CEREBLON ISOFORM 4)		 2iou MAJOR TROPISM
DETERMINANT P1
(Bordetella
virus
BPP1) 		4 / 7 ASN A 291
PHE A 293
TRP A 290
TYR A 194
 None
 1.40A 5oh1B-2iouA:
undetectable		 5oh1B-2iouA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGJ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		3 / 3 VAL G 168
VAL G 146
GLN G 152
 None
 0.61A 5qgjA-2iouG:
undetectable		 5qgjA-2iouG:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGL_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		3 / 3 VAL G 168
VAL G 146
GLN G 152
 None
 0.71A 5qglA-2iouG:
undetectable		 5qglA-2iouG:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGM_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		3 / 3 VAL G 168
VAL G 146
GLN G 152
 None
 0.58A 5qgmA-2iouG:
undetectable		 5qgmA-2iouG:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGN_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		3 / 3 VAL G 168
VAL G 146
GLN G 152
 None
 0.65A 5qgnA-2iouG:
undetectable		 5qgnA-2iouG:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGU_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		3 / 3 VAL G 168
VAL G 146
GLN G 152
 None
 0.68A 5qguA-2iouG:
undetectable		 5qguA-2iouG:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGV_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		3 / 3 VAL G 168
VAL G 146
GLN G 152
 None
 0.69A 5qgvA-2iouG:
undetectable		 5qgvA-2iouG:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGW_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		3 / 3 VAL G 168
VAL G 146
GLN G 152
 None
 0.69A 5qgwA-2iouG:
undetectable		 5qgwA-2iouG:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGX_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		3 / 3 VAL G 168
VAL G 146
GLN G 152
 None
 0.69A 5qgxA-2iouG:
undetectable		 5qgxA-2iouG:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH1_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		3 / 3 VAL G 168
VAL G 146
GLN G 152
 None
 0.70A 5qh1A-2iouG:
undetectable		 5qh1A-2iouG:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH4_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		3 / 3 VAL G 168
VAL G 146
GLN G 152
 None
 0.67A 5qh4A-2iouG:
undetectable		 5qh4A-2iouG:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH5_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		3 / 3 VAL G 168
VAL G 146
GLN G 152
 None
 0.64A 5qh5A-2iouG:
undetectable		 5qh5A-2iouG:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH6_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		3 / 3 VAL G 168
VAL G 146
GLN G 152
 None
 0.65A 5qh6A-2iouG:
undetectable		 5qh6A-2iouG:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH7_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		3 / 3 VAL G 168
VAL G 146
GLN G 152
 None
 0.67A 5qh7A-2iouG:
undetectable		 5qh7A-2iouG:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH9_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		3 / 3 VAL G 168
VAL G 146
GLN G 152
 None
 0.63A 5qh9A-2iouG:
undetectable		 5qh9A-2iouG:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHC_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		3 / 3 VAL G 168
VAL G 146
GLN G 152
 None
 0.68A 5qhcA-2iouG:
undetectable		 5qhcA-2iouG:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHE_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		3 / 3 VAL G 168
VAL G 146
GLN G 152
 None
 0.68A 5qheA-2iouG:
undetectable		 5qheA-2iouG:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHF_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		3 / 3 VAL G 168
VAL G 146
GLN G 152
 None
 0.66A 5qhfA-2iouG:
undetectable		 5qhfA-2iouG:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		3 / 3 VAL G 168
VAL G 146
GLN G 152
 None
 0.65A 5qhgA-2iouG:
undetectable		 5qhgA-2iouG:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHH_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		3 / 3 VAL G 168
VAL G 146
GLN G 152
 None
 0.67A 5qhhA-2iouG:
undetectable		 5qhhA-2iouG:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 2iou MAJOR TROPISM
DETERMINANT P1
(Bordetella
virus
BPP1) 		4 / 7 TRP A 345
SER A 270
SER A 351
GLY A 342
 None
 0.92A 6btxA-2iouA:
undetectable		 6btxA-2iouA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_I_EY4I500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		4 / 5 GLN G 528
VAL G 527
TRP G 563
THR G 538
 None
 1.27A 6cduI-2iouG:
undetectable
6cduJ-2iouG:
undetectable		 6cduI-2iouG:
20.15
6cduJ-2iouG:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 2iou MAJOR TROPISM
DETERMINANT P1
(Bordetella
virus
BPP1) 		5 / 9 TYR A 165
GLY A 181
SER A 206
VAL A 299
ILE A 193
 None
 1.15A 6giqA-2iouA:
0.0
6giqE-2iouA:
0.0
6giqI-2iouA:
0.0		 6giqA-2iouA:
24.03
6giqE-2iouA:
18.78
6giqI-2iouA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		5 / 10 PHE G 469
ASN G 513
ASP G 490
LEU G 491
ASN G 522
 None
 1.31A 6r2eB-2iouG:
undetectable		 6r2eB-2iouG:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 2iou PERTACTIN
EXTRACELLULAR DOMAIN
(Bordetella
bronchiseptica) 		5 / 12 ASN G 513
TYR G 553
ASP G 490
LEU G 491
ASN G 522
 None
 1.02A 6r2eH-2iouG:
undetectable		 6r2eH-2iouG:
20.00