SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ioy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 2ioy PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Caldanaerobacter
subterraneus) 		4 / 8 ALA A  27
GLY A 245
VAL A  36
ILE A  34
 None
 0.60A 1d4yB-2ioyA:
undetectable		 1d4yB-2ioyA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 2ioy PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Caldanaerobacter
subterraneus) 		4 / 8 LEU A 129
ARG A 141
PHE A 145
GLY A 109
 None
RIP  A 401 (-3.0A)
None
None
 0.86A 1fapB-2ioyA:
undetectable		 1fapB-2ioyA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_A_NIOA145_1
(LEGHEMOGLOBIN A)		 2ioy PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Caldanaerobacter
subterraneus) 		4 / 8 TYR A  32
ILE A   4
LEU A 253
VAL A  60
 None
 0.85A 1fslA-2ioyA:
undetectable		 1fslA-2ioyA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)		 2ioy PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Caldanaerobacter
subterraneus) 		4 / 6 GLU A 128
LEU A 129
VAL A 173
MET A 174
 None
 1.04A 1hk1A-2ioyA:
undetectable		 1hk1A-2ioyA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA156_1
(CALMODULIN)		 2ioy PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Caldanaerobacter
subterraneus) 		5 / 8 ILE A 202
LEU A 178
ILE A 184
VAL A 187
ILE A 210
 None
 1.47A 1linA-2ioyA:
undetectable		 1linA-2ioyA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2ioy PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Caldanaerobacter
subterraneus) 		4 / 5 ASP A 250
LEU A  62
ALA A  27
LEU A  30
 None
 1.11A 1nh8A-2ioyA:
2.4		 1nh8A-2ioyA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_1
(POL PROTEIN)		 2ioy PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Caldanaerobacter
subterraneus) 		5 / 12 ALA A  27
GLY A 245
GLY A 242
VAL A  36
ILE A  34
 None
 0.83A 2fxeA-2ioyA:
undetectable		 2fxeA-2ioyA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 2ioy PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Caldanaerobacter
subterraneus) 		4 / 6 THR A 218
THR A 233
ASN A 105
ASP A 140
 None
 1.19A 2okcA-2ioyA:
undetectable		 2okcA-2ioyA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 2ioy PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Caldanaerobacter
subterraneus) 		5 / 12 PHE A 165
ALA A 195
ALA A 163
ILE A 234
THR A 218
 RIP  A 401 (-3.4A)
None
None
None
None
 1.23A 3dl9B-2ioyA:
undetectable		 3dl9B-2ioyA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 2ioy PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Caldanaerobacter
subterraneus) 		5 / 12 GLY A   5
VAL A  50
ILE A  63
ASN A  64
GLU A  46
 None
 1.40A 3jb2A-2ioyA:
undetectable		 3jb2A-2ioyA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 2ioy PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Caldanaerobacter
subterraneus) 		4 / 7 PHE A  16
PHE A  15
ALA A 137
LEU A 266
 RIP  A 401 (-4.5A)
RIP  A 401 (-3.6A)
RIP  A 401 (-3.2A)
None
 0.92A 4ejgC-2ioyA:
undetectable		 4ejgC-2ioyA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 2ioy PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Caldanaerobacter
subterraneus) 		4 / 8 ALA A  27
GLY A 245
VAL A  36
ILE A  34
 None
 0.63A 4ll3A-2ioyA:
undetectable		 4ll3A-2ioyA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 2ioy PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Caldanaerobacter
subterraneus) 		4 / 5 LEU A  53
ASP A  52
LEU A  61
THR A   3
 None
 1.12A 4wozF-2ioyA:
undetectable
4wozH-2ioyA:
undetectable		 4wozF-2ioyA:
22.73
4wozH-2ioyA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 2ioy PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Caldanaerobacter
subterraneus) 		4 / 7 GLY A 108
ASP A 104
GLY A 144
GLU A 147
 None
 0.92A 4z53A-2ioyA:
2.1
4z53B-2ioyA:
2.4		 4z53A-2ioyA:
19.38
4z53B-2ioyA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2ioy PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Caldanaerobacter
subterraneus) 		4 / 7 ALA A 135
ASP A 104
GLY A 109
GLU A 110
 RIP  A 401 ( 4.8A)
None
None
None
 0.93A 5btgA-2ioyA:
undetectable
5btgC-2ioyA:
undetectable
5btgD-2ioyA:
3.7		 5btgA-2ioyA:
21.19
5btgC-2ioyA:
21.19
5btgD-2ioyA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2ioy PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Caldanaerobacter
subterraneus) 		6 / 12 LEU A 196
PHE A 215
GLY A 217
GLN A 236
ILE A 225
MET A 230
 None
None
None
RIP  A 401 (-3.2A)
None
None
 1.32A 5y2tA-2ioyA:
undetectable		 5y2tA-2ioyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 2ioy PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Caldanaerobacter
subterraneus) 		3 / 3 LEU A  62
ASP A  52
ILE A  54
 None
 0.64A 6dh0B-2ioyA:
undetectable		 6dh0B-2ioyA:
14.81