SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ip1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9H_A_RAPA108_1
(FKBP12.6)		 2ip1 TRYPTOPHANYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 401
ILE A 175
PHE A 404
HIS A 173
PHE A 405
 None
 1.17A 1c9hA-2ip1A:
undetectable		 1c9hA-2ip1A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 2ip1 TRYPTOPHANYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 448
THR A 455
VAL A 451
 None
 0.79A 1hxbA-2ip1A:
undetectable		 1hxbA-2ip1A:
14.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2ip1 TRYPTOPHANYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		7 / 12 THR A 160
GLY A 161
GLY A 163
THR A 196
GLU A 199
ILE A 306
PHE A 316
 None
PG4  A 950 ( 4.3A)
PG4  A 950 (-3.9A)
PG4  A 950 (-3.5A)
PG4  A 950 (-3.7A)
None
PG4  A 950 ( 4.8A)
 0.67A 2akeA-2ip1A:
49.4		 2akeA-2ip1A:
48.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2ip1 TRYPTOPHANYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		7 / 12 TYR A 159
THR A 160
GLY A 161
GLY A 163
THR A 196
GLU A 199
ILE A 306
 None
None
PG4  A 950 ( 4.3A)
PG4  A 950 (-3.9A)
PG4  A 950 (-3.5A)
PG4  A 950 (-3.7A)
None
 0.60A 2akeA-2ip1A:
49.4		 2akeA-2ip1A:
48.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2ip1 TRYPTOPHANYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		6 / 12 TYR A 159
THR A 160
GLY A 161
GLY A 163
THR A 196
LYS A 200
 None
None
PG4  A 950 ( 4.3A)
PG4  A 950 (-3.9A)
PG4  A 950 (-3.5A)
None
 0.80A 2akeA-2ip1A:
49.4		 2akeA-2ip1A:
48.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2ip1 TRYPTOPHANYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		7 / 12 THR A 160
GLY A 161
GLY A 163
THR A 196
GLU A 199
ILE A 306
PHE A 316
 None
PG4  A 950 ( 4.3A)
PG4  A 950 (-3.9A)
PG4  A 950 (-3.5A)
PG4  A 950 (-3.7A)
None
PG4  A 950 ( 4.8A)
 0.73A 2azxA-2ip1A:
49.0		 2azxA-2ip1A:
46.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2ip1 TRYPTOPHANYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 159
THR A 160
GLY A 161
GLN A 283
ILE A 306
 None
None
PG4  A 950 ( 4.3A)
PG4  A 950 ( 4.0A)
None
 1.19A 2azxA-2ip1A:
49.0		 2azxA-2ip1A:
46.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2ip1 TRYPTOPHANYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		7 / 12 TYR A 159
THR A 160
GLY A 161
GLY A 163
THR A 196
GLU A 199
ILE A 306
 None
None
PG4  A 950 ( 4.3A)
PG4  A 950 (-3.9A)
PG4  A 950 (-3.5A)
PG4  A 950 (-3.7A)
None
 0.62A 2azxA-2ip1A:
49.0		 2azxA-2ip1A:
46.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2ip1 TRYPTOPHANYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 159
GLU A 199
ILE A 306
CYH A 308
PHE A 316
 None
PG4  A 950 (-3.7A)
None
None
PG4  A 950 ( 4.8A)
 1.12A 2azxB-2ip1A:
49.0		 2azxB-2ip1A:
46.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2ip1 TRYPTOPHANYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 159
ILE A 306
CYH A 308
GLN A 312
PHE A 316
 None
None
None
PG4  A 950 (-4.2A)
PG4  A 950 ( 4.8A)
 1.03A 2azxB-2ip1A:
49.0		 2azxB-2ip1A:
46.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2ip1 TRYPTOPHANYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 159
THR A 160
GLY A 161
GLN A 283
ILE A 306
 None
None
PG4  A 950 ( 4.3A)
PG4  A 950 ( 4.0A)
None
 1.19A 2azxB-2ip1A:
49.0		 2azxB-2ip1A:
46.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2ip1 TRYPTOPHANYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		8 / 12 TYR A 159
THR A 160
GLY A 161
GLY A 163
THR A 196
GLU A 199
ILE A 306
PHE A 316
 None
None
PG4  A 950 ( 4.3A)
PG4  A 950 (-3.9A)
PG4  A 950 (-3.5A)
PG4  A 950 (-3.7A)
None
PG4  A 950 ( 4.8A)
 0.83A 2azxB-2ip1A:
49.0		 2azxB-2ip1A:
46.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG4_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 2ip1 TRYPTOPHANYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		5 / 11 TYR A 401
ILE A 175
PHE A 404
HIS A 173
PHE A 405
 None
 1.18A 2dg4A-2ip1A:
undetectable		 2dg4A-2ip1A:
15.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2ip1 TRYPTOPHANYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		6 / 11 GLY A 161
GLY A 163
THR A 196
GLU A 199
ILE A 306
PHE A 316
 PG4  A 950 ( 4.3A)
PG4  A 950 (-3.9A)
PG4  A 950 (-3.5A)
PG4  A 950 (-3.7A)
None
PG4  A 950 ( 4.8A)
 0.70A 2dr2A-2ip1A:
49.4		 2dr2A-2ip1A:
48.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2ip1 TRYPTOPHANYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		6 / 11 TYR A 159
GLY A 161
GLY A 163
THR A 196
GLU A 199
ILE A 306
 None
PG4  A 950 ( 4.3A)
PG4  A 950 (-3.9A)
PG4  A 950 (-3.5A)
PG4  A 950 (-3.7A)
None
 0.61A 2dr2A-2ip1A:
49.4		 2dr2A-2ip1A:
48.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 2ip1 TRYPTOPHANYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 448
THR A 455
VAL A 451
 None
 0.79A 2qakA-2ip1A:
undetectable		 2qakA-2ip1A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 2ip1 TRYPTOPHANYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		4 / 7 GLU A 194
ASP A 238
SER A 291
THR A 249
 None
 1.36A 3dzgB-2ip1A:
undetectable		 3dzgB-2ip1A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 2ip1 TRYPTOPHANYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 266
GLY A 267
PHE A 268
PHE A 279
 None
 1.07A 3ko0D-2ip1A:
undetectable
3ko0E-2ip1A:
undetectable		 3ko0D-2ip1A:
12.96
3ko0E-2ip1A:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 2ip1 TRYPTOPHANYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 440
VAL A 441
ILE A 367
ALA A 398
 None
 1.02A 4eyzA-2ip1A:
undetectable		 4eyzA-2ip1A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 2ip1 TRYPTOPHANYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 279
LEU A 202
SER A 281
THR A 286
 None
 1.01A 4wnvD-2ip1A:
undetectable		 4wnvD-2ip1A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2ip1 TRYPTOPHANYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 150
PHE A 143
ILE A 146
PHE A 120
 None
 0.90A 5eseA-2ip1A:
0.0		 5eseA-2ip1A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2ip1 TRYPTOPHANYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 150
PHE A 143
ILE A 146
PHE A 120
 None
 0.88A 5esfA-2ip1A:
undetectable		 5esfA-2ip1A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HKG_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B)		 2ip1 TRYPTOPHANYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 401
ILE A 175
PHE A 404
HIS A 173
PHE A 405
 None
 1.13A 5hkgA-2ip1A:
undetectable		 5hkgA-2ip1A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 2ip1 TRYPTOPHANYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 189
ARG A 141
PRO A 331
 None
 0.83A 5koxA-2ip1A:
undetectable		 5koxA-2ip1A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 2ip1 TRYPTOPHANYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		3 / 3 ALA A 285
VAL A 192
TYR A 159
 None
 0.69A 5zmqH-2ip1A:
undetectable		 5zmqH-2ip1A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 2ip1 TRYPTOPHANYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 313
ARG A 317
ASP A 142
 None
 0.85A 5zvgB-2ip1A:
undetectable		 5zvgB-2ip1A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)		 2ip1 TRYPTOPHANYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		4 / 5 THR A 116
THR A 109
HIS A 335
GLY A 135
 None
 1.04A 6gbnC-2ip1A:
undetectable		 6gbnC-2ip1A:
23.25