SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ip2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 2ip2 PROBABLE
PHENAZINE-SPECIFIC
METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 8 ASP A 173
GLY A 176
GLY A 179
SER A 240
 None
 0.42A 1qzzA-2ip2A:
20.4		 1qzzA-2ip2A:
28.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 2ip2 PROBABLE
PHENAZINE-SPECIFIC
METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 SER A 178
LEU A 147
LEU A 291
HIS A 290
PHE A 146
 None
 1.38A 1uobA-2ip2A:
undetectable		 1uobA-2ip2A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 2ip2 PROBABLE
PHENAZINE-SPECIFIC
METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 218
ARG A 193
ILE A 185
 None
 0.80A 1uobA-2ip2A:
undetectable		 1uobA-2ip2A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2ip2 PROBABLE
PHENAZINE-SPECIFIC
METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 7 LEU A 291
PHE A 146
MET A 150
SER A 153
 None
 1.10A 1wrlA-2ip2A:
undetectable
1wrlB-2ip2A:
undetectable		 1wrlA-2ip2A:
13.60
1wrlB-2ip2A:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2ip2 PROBABLE
PHENAZINE-SPECIFIC
METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 291
PHE A 146
MET A 150
SER A 153
 None
 1.08A 1wrlB-2ip2A:
undetectable		 1wrlB-2ip2A:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 2ip2 PROBABLE
PHENAZINE-SPECIFIC
METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 175
GLY A 176
GLY A 177
ASP A 225
SER A 240
 None
 0.38A 1xdsA-2ip2A:
22.3		 1xdsA-2ip2A:
28.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 2ip2 PROBABLE
PHENAZINE-SPECIFIC
METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 175
GLY A 176
GLY A 177
ASP A 225
SER A 240
 None
 0.43A 1xdsB-2ip2A:
24.9		 1xdsB-2ip2A:
28.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2ip2 PROBABLE
PHENAZINE-SPECIFIC
METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 ASP A 173
GLY A 175
GLY A 177
LEU A 181
LEU A 246
 None
 0.85A 2nxeA-2ip2A:
15.2		 2nxeA-2ip2A:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_F_BEZF1222_0
(PEROXIREDOXIN 6.)		 2ip2 PROBABLE
PHENAZINE-SPECIFIC
METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 7 THR A  82
PRO A  83
SER A  85
GLU A  69
 None
 1.08A 2v41E-2ip2A:
undetectable
2v41F-2ip2A:
undetectable		 2v41E-2ip2A:
20.87
2v41F-2ip2A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2ip2 PROBABLE
PHENAZINE-SPECIFIC
METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 ASP A 173
GLY A 175
LEU A 181
ASP A 198
LEU A 246
 None
 0.94A 3cjtC-2ip2A:
15.1		 3cjtC-2ip2A:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 2ip2 PROBABLE
PHENAZINE-SPECIFIC
METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		6 / 12 GLY A 177
LEU A 181
LEU A 197
ASP A 225
MET A 226
SER A 240
 None
 0.88A 3g2oB-2ip2A:
19.6		 3g2oB-2ip2A:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 2ip2 PROBABLE
PHENAZINE-SPECIFIC
METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 8 HIS A  86
SER A  85
LEU A  47
ASP A  35
 None
 1.19A 3n2oC-2ip2A:
undetectable
3n2oD-2ip2A:
undetectable		 3n2oC-2ip2A:
20.15
3n2oD-2ip2A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2ip2 PROBABLE
PHENAZINE-SPECIFIC
METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		3 / 3 GLY A 177
ASP A 198
ASP A 225
 None
 0.25A 3ou7C-2ip2A:
15.5		 3ou7C-2ip2A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 2ip2 PROBABLE
PHENAZINE-SPECIFIC
METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 241
MET A 324
ARG A 273
 None
 1.33A 3uvvA-2ip2A:
undetectable		 3uvvA-2ip2A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 2ip2 PROBABLE
PHENAZINE-SPECIFIC
METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 9 MET A 150
PHE A 146
LEU A 136
GLY A 143
ALA A 116
 None
 1.16A 4l6va-2ip2A:
0.0
4l6vf-2ip2A:
0.0		 4l6va-2ip2A:
17.11
4l6vf-2ip2A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 2ip2 PROBABLE
PHENAZINE-SPECIFIC
METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		6 / 11 GLY A 175
GLY A 176
ASP A 198
ASP A 225
MET A 226
ILE A 242
 None
 0.36A 4pghA-2ip2A:
13.7		 4pghA-2ip2A:
27.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 2ip2 PROBABLE
PHENAZINE-SPECIFIC
METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 11 GLY A 177
ASP A 198
ASP A 225
MET A 226
ILE A 242
 None
 1.07A 4pghA-2ip2A:
13.7		 4pghA-2ip2A:
27.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 2ip2 PROBABLE
PHENAZINE-SPECIFIC
METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		7 / 12 ASP A 173
GLY A 175
ASP A 198
ASP A 225
MET A 226
ILE A 242
ASP A 245
 None
 0.61A 4pghB-2ip2A:
11.3		 4pghB-2ip2A:
27.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_C_SAMC401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 2ip2 PROBABLE
PHENAZINE-SPECIFIC
METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 11 GLY A 175
ASP A 198
ASP A 225
MET A 226
ILE A 242
 None
 0.44A 4pghC-2ip2A:
30.3		 4pghC-2ip2A:
27.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 2ip2 PROBABLE
PHENAZINE-SPECIFIC
METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 5 GLY A 143
ARG A 145
GLU A 105
PHE A 101
 None
 1.23A 4r82A-2ip2A:
undetectable
4r82B-2ip2A:
undetectable		 4r82A-2ip2A:
20.98
4r82B-2ip2A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 2ip2 PROBABLE
PHENAZINE-SPECIFIC
METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 7 LEU A 254
SER A 251
ILE A 243
VAL A 305
 None
 1.23A 4tvtA-2ip2A:
undetectable		 4tvtA-2ip2A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2ip2 PROBABLE
PHENAZINE-SPECIFIC
METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 6 GLU A 217
GLY A 176
ASP A 198
GLY A 179
 None
 0.89A 5cdnA-2ip2A:
0.9
5cdnB-2ip2A:
undetectable		 5cdnA-2ip2A:
25.00
5cdnB-2ip2A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_0
(MINERALOCORTICOID
RECEPTOR)		 2ip2 PROBABLE
PHENAZINE-SPECIFIC
METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  88
LEU A  87
SER A 153
LEU A 155
MET A 324
 None
 1.19A 5mwyA-2ip2A:
undetectable		 5mwyA-2ip2A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 2ip2 PROBABLE
PHENAZINE-SPECIFIC
METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 7 LEU A  61
ALA A  28
ILE A  37
LEU A  47
 None
 0.94A 5te8C-2ip2A:
undetectable		 5te8C-2ip2A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2ip2 PROBABLE
PHENAZINE-SPECIFIC
METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 242
PHE A 146
LEU A 291
HIS A 290
PHE A 132
 None
 1.33A 5v5zA-2ip2A:
undetectable		 5v5zA-2ip2A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA820_0
(GEPHYRIN)		 2ip2 PROBABLE
PHENAZINE-SPECIFIC
METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 5 GLU A 115
PRO A 112
THR A 111
MET A 293
 None
 1.47A 6fgdA-2ip2A:
3.2		 6fgdA-2ip2A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 2ip2 PROBABLE
PHENAZINE-SPECIFIC
METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		6 / 11 GLY A 175
GLY A 177
ASP A 198
ASP A 225
MET A 226
ASP A 245
 None
 0.56A 6i5zD-2ip2A:
28.7		 6i5zD-2ip2A:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 2ip2 PROBABLE
PHENAZINE-SPECIFIC
METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 11 GLY A 176
ASP A 198
ASP A 225
MET A 226
ASP A 245
 None
 1.07A 6i5zD-2ip2A:
28.7		 6i5zD-2ip2A:
25.19