SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ip4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Thermus
thermophilus) 		4 / 8 ALA A 192
LEU A 244
LEU A 247
LEU A 310
 None
 0.95A 1ereE-2ip4A:
undetectable		 1ereE-2ip4A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Thermus
thermophilus) 		4 / 8 ALA A 192
LEU A 244
LEU A 247
LEU A 310
 None
 0.96A 1ereF-2ip4A:
undetectable		 1ereF-2ip4A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Thermus
thermophilus) 		4 / 8 VAL A 344
LEU A 373
PRO A 347
HIS A  13
 None
 1.04A 1jtvA-2ip4A:
3.9		 1jtvA-2ip4A:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Thermus
thermophilus) 		5 / 9 LEU A  66
VAL A 261
VAL A 305
GLY A 260
LEU A  15
 None
 1.48A 1lwfA-2ip4A:
undetectable		 1lwfA-2ip4A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_2
(PROTEASE)		 2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Thermus
thermophilus) 		5 / 11 GLY A 377
ALA A 385
ASP A 381
GLY A 408
ILE A 407
 None
 0.92A 1n49B-2ip4A:
undetectable		 1n49B-2ip4A:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_1
(PROTEASE)		 2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Thermus
thermophilus) 		5 / 11 GLY A 377
ALA A 385
ASP A 381
GLY A 408
ILE A 407
 None
 0.94A 1n49C-2ip4A:
undetectable		 1n49C-2ip4A:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		 2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Thermus
thermophilus) 		4 / 6 ASP A  79
GLY A  76
THR A  92
PRO A  91
 None
 0.93A 1n4fA-2ip4A:
undetectable		 1n4fA-2ip4A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Thermus
thermophilus) 		3 / 3 LEU A  15
LEU A  88
PHE A 282
 None
 0.68A 2pgrA-2ip4A:
undetectable		 2pgrA-2ip4A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Thermus
thermophilus) 		3 / 3 LEU A 126
PRO A 125
LEU A 129
 None
 0.60A 2po5B-2ip4A:
2.3		 2po5B-2ip4A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Thermus
thermophilus) 		5 / 12 LEU A  28
ASP A  63
ALA A  19
VAL A   6
LEU A  66
 None
 1.00A 2yqzA-2ip4A:
3.9		 2yqzA-2ip4A:
26.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Thermus
thermophilus) 		6 / 8 ASP A 207
TYR A 263
ASN A 279
ARG A 281
GLY A 283
PRO A 285
 None
None
None
SO4  A 418 (-2.9A)
None
None
 0.60A 2ys6A-2ip4A:
53.6		 2ys6A-2ip4A:
50.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Thermus
thermophilus) 		5 / 8 ASP A 207
TYR A 263
GLY A 283
PRO A 285
GLU A 286
 None
 0.79A 2ys6A-2ip4A:
53.6		 2ys6A-2ip4A:
50.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Thermus
thermophilus) 		5 / 8 LYS A 209
TYR A 263
ASN A 279
ARG A 281
GLY A 283
 None
None
None
SO4  A 418 (-2.9A)
None
 0.73A 2ys6A-2ip4A:
53.6		 2ys6A-2ip4A:
50.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Thermus
thermophilus) 		5 / 12 GLY A 369
GLY A 339
ALA A 328
LEU A 342
ILE A 340
 SO4  A 419 ( 4.8A)
None
None
None
None
 1.04A 3ku1G-2ip4A:
4.2		 3ku1G-2ip4A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Thermus
thermophilus) 		4 / 5 LEU A 386
GLN A 206
HIS A 208
GLY A 408
 None
 1.23A 3pp1A-2ip4A:
undetectable		 3pp1A-2ip4A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Thermus
thermophilus) 		4 / 8 ASP A 207
GLY A 222
GLU A 187
ARG A 281
 None
None
None
SO4  A 418 (-2.9A)
 0.93A 3s3nA-2ip4A:
undetectable		 3s3nA-2ip4A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)		 2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Thermus
thermophilus) 		3 / 3 ASP A 143
GLU A 176
GLY A 175
 None
 0.63A 3w9tA-2ip4A:
undetectable		 3w9tA-2ip4A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Thermus
thermophilus) 		5 / 12 PRO A 348
LEU A 327
TYR A 403
VAL A 325
ALA A 391
 None
 1.44A 4a84A-2ip4A:
undetectable		 4a84A-2ip4A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Thermus
thermophilus) 		5 / 12 LEU A  66
VAL A   3
MET A   1
LEU A 310
LEU A 315
 None
 1.30A 4o8fB-2ip4A:
undetectable		 4o8fB-2ip4A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Thermus
thermophilus) 		4 / 8 GLU A 197
LEU A 244
LEU A 251
GLY A 260
 None
 0.76A 4r3aA-2ip4A:
undetectable		 4r3aA-2ip4A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_F_EVPF102_1
(DNA TOPOISOMERASE
2-ALPHA)		 2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Thermus
thermophilus) 		4 / 5 GLY A 408
ASP A 406
ARG A 404
MET A 267
 None
 1.41A 5gwkA-2ip4A:
undetectable		 5gwkA-2ip4A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Thermus
thermophilus) 		3 / 3 LEU A  15
LEU A 298
ARG A  27
 None
 0.66A 5hnzB-2ip4A:
undetectable		 5hnzB-2ip4A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Thermus
thermophilus) 		4 / 6 GLU A  12
PRO A  32
GLY A   9
ARG A 359
 None
 1.27A 5jcnB-2ip4A:
3.7		 5jcnB-2ip4A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Thermus
thermophilus) 		3 / 3 LYS A   1
ASP A  63
ARG A  24
 None
 1.06A 5jwaA-2ip4A:
3.8
5jwaH-2ip4A:
4.0		 5jwaA-2ip4A:
18.53
5jwaH-2ip4A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Thermus
thermophilus) 		5 / 10 ALA A 105
LEU A 108
LEU A 247
VAL A 275
ILE A 243
 None
 0.96A 5v02B-2ip4A:
undetectable
5v02R-2ip4A:
undetectable		 5v02B-2ip4A:
12.44
5v02R-2ip4A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Thermus
thermophilus) 		5 / 12 CYH A 324
ALA A 322
GLY A 350
ASP A 207
GLY A 224
 None
 1.02A 5wwsA-2ip4A:
2.7		 5wwsA-2ip4A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Thermus
thermophilus) 		5 / 12 CYH A 324
ALA A 322
GLY A 350
ASP A 207
GLY A 224
 None
 1.02A 5wwsB-2ip4A:
2.4		 5wwsB-2ip4A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Thermus
thermophilus) 		5 / 12 VAL A 305
VAL A   3
MET A   1
LEU A 315
LEU A 193
 None
 1.32A 5x23A-2ip4A:
undetectable		 5x23A-2ip4A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Thermus
thermophilus) 		5 / 12 VAL A 178
GLY A 149
GLY A 151
VAL A 141
ALA A 148
 None
 0.86A 5x7fA-2ip4A:
4.9		 5x7fA-2ip4A:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Thermus
thermophilus) 		3 / 3 THR A 189
GLU A 286
HIS A 208
 None
 0.92A 5xioA-2ip4A:
3.5		 5xioA-2ip4A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Thermus
thermophilus) 		3 / 3 THR A 189
GLU A 286
HIS A 208
 None
 0.87A 5xiqB-2ip4A:
undetectable		 5xiqB-2ip4A:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Thermus
thermophilus) 		5 / 12 VAL A 305
PHE A 282
LEU A  15
GLN A  21
LEU A 294
 None
 1.19A 6ew0G-2ip4A:
undetectable		 6ew0G-2ip4A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Thermus
thermophilus) 		4 / 7 ALA A 264
GLY A 265
LEU A 276
GLY A 100
 None
 0.66A 6nm4A-2ip4A:
undetectable		 6nm4A-2ip4A:
18.35