SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ipa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2ipa THIOREDOXIN
(Bacillus
subtilis) 		4 / 7 LYS A  93
LEU A  96
GLN A  97
LEU A  75
 None
 1.06A 2einC-2ipaA:
undetectable
2einJ-2ipaA:
undetectable		 2einC-2ipaA:
17.12
2einJ-2ipaA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 2ipa THIOREDOXIN
(Bacillus
subtilis) 		5 / 10 LEU A  42
LEU A  39
SER A  87
LEU A  75
LEU A  96
 None
 1.14A 2xn7A-2ipaA:
undetectable
2xn7B-2ipaA:
undetectable		 2xn7A-2ipaA:
13.71
2xn7B-2ipaA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)		 2ipa THIOREDOXIN
(Bacillus
subtilis) 		4 / 8 LYS A  54
ASP A  23
LEU A  42
LEU A  21
 None
 0.99A 3lm8A-2ipaA:
undetectable
3lm8C-2ipaA:
undetectable		 3lm8A-2ipaA:
19.82
3lm8C-2ipaA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 2ipa THIOREDOXIN
PROTEIN ARSC
(Bacillus
subtilis;
Bacillus
subtilis) 		3 / 3 SER B  69
GLY A  68
SER A  71
 None
 0.56A 3loqA-2ipaB:
undetectable		 3loqA-2ipaB:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2ipa PROTEIN ARSC
(Bacillus
subtilis) 		4 / 4 ASN B  47
SER B  17
ALA B  48
VAL B  49
 None
 1.12A 4x1kC-2ipaB:
3.4		 4x1kC-2ipaB:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		 2ipa PROTEIN ARSC
(Bacillus
subtilis) 		4 / 7 GLU B  21
ASP B  65
ALA B  37
TYR B  35
 None
 1.20A 4zz8A-2ipaB:
undetectable		 4zz8A-2ipaB:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 2ipa PROTEIN ARSC
(Bacillus
subtilis) 		4 / 6 ALA B  37
SER B  36
SER B  82
PRO B  90
 None
 1.15A 5c6pA-2ipaB:
undetectable		 5c6pA-2ipaB:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 2ipa PROTEIN ARSC
(Bacillus
subtilis) 		3 / 3 ARG B  16
PRO B 106
ASN B  47
 None
 1.08A 5jwaA-2ipaB:
4.7
5jwaH-2ipaB:
4.6		 5jwaA-2ipaB:
14.20
5jwaH-2ipaB:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2ipa PROTEIN ARSC
(Bacillus
subtilis) 		4 / 4 ASN B  47
SER B  17
ALA B  48
VAL B  49
 None
 1.04A 5nm5A-2ipaB:
3.8		 5nm5A-2ipaB:
16.04