SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ipc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_A_CAMA502_0
(CYTOCHROME P450-CAM)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		4 / 6 TYR A 378
LEU A 179
VAL A 126
VAL A 113
 None
 1.18A 1dz4A-2ipcA:
undetectable		 1dz4A-2ipcA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		4 / 8 PHE A 429
GLY A 427
ARG A 472
VAL A 420
 None
 0.97A 1gsfC-2ipcA:
2.5		 1gsfC-2ipcA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		4 / 7 THR A 110
LEU A 115
GLY A  88
LEU A  85
 None
 1.05A 1gtiD-2ipcA:
undetectable		 1gtiD-2ipcA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		4 / 8 LEU A 149
VAL A 123
GLY A 122
TYR A 144
 None
 0.90A 1jlbA-2ipcA:
undetectable		 1jlbA-2ipcA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		4 / 8 LEU A 149
VAL A 123
GLY A 122
TYR A 144
 None
 0.92A 1jlfA-2ipcA:
undetectable
1jlfB-2ipcA:
undetectable		 1jlfA-2ipcA:
20.25
1jlfB-2ipcA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		4 / 7 LEU A 149
VAL A 123
GLY A 122
TYR A 144
 None
 0.92A 1lweA-2ipcA:
undetectable		 1lweA-2ipcA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		4 / 8 ILE A 154
GLY A 152
SER A 158
GLU A 162
 None
 0.90A 1mrjA-2ipcA:
undetectable		 1mrjA-2ipcA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_B_CHCB201_1
(BILE ACID RECEPTOR)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		5 / 12 PHE A 375
ILE A  96
PHE A 395
ILE A 216
TYR A 399
 None
 1.23A 1osvB-2ipcA:
0.1		 1osvB-2ipcA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		4 / 8 LEU A 149
VAL A 123
GLY A 122
TYR A 144
 None
 0.92A 1s1xA-2ipcA:
undetectable		 1s1xA-2ipcA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		3 / 3 GLU A 435
GLU A 441
LEU A 658
 None
 0.71A 1v8bB-2ipcA:
undetectable		 1v8bB-2ipcA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		3 / 3 GLY A 686
ASP A 687
ASN A 409
 None
 0.67A 1vq1A-2ipcA:
3.4		 1vq1A-2ipcA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		5 / 12 PRO A 445
GLY A 690
GLY A 689
GLY A 660
SER A 691
 None
 1.19A 1wg8A-2ipcA:
undetectable		 1wg8A-2ipcA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		5 / 12 LEU A 585
GLY A 686
GLY A 683
GLY A 680
ARG A 679
 None
 1.23A 1y4lA-2ipcA:
undetectable		 1y4lA-2ipcA:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		3 / 3 TRP A 607
LEU A 627
LYS A 615
 None
 1.23A 1yajK-2ipcA:
0.0		 1yajK-2ipcA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		5 / 11 PHE A 293
GLY A 279
THR A 261
ILE A 308
LEU A 304
 None
 0.93A 1z11A-2ipcA:
undetectable		 1z11A-2ipcA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		5 / 11 PHE A 293
GLY A 279
THR A 261
ILE A 308
LEU A 304
 None
 0.87A 1z11B-2ipcA:
undetectable		 1z11B-2ipcA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		4 / 6 ALA A 219
TYR A 399
ILE A 216
ILE A 214
 None
 0.90A 2dcfA-2ipcA:
undetectable		 2dcfA-2ipcA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		5 / 12 HIS A 201
ALA A 114
THR A 110
ALA A 109
HIS A  92
 None
 0.98A 2gluA-2ipcA:
2.1		 2gluA-2ipcA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		5 / 12 THR A 119
ALA A 112
TYR A 144
LEU A 179
TYR A 378
 None
 0.91A 2nyrA-2ipcA:
2.2		 2nyrA-2ipcA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		4 / 8 SER A 452
ILE A 451
ASP A 700
ARG A 703
 None
 1.09A 2v57A-2ipcA:
undetectable		 2v57A-2ipcA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		4 / 8 SER A 452
ILE A 451
ASP A 700
ARG A 703
 None
 1.09A 2v57C-2ipcA:
undetectable		 2v57C-2ipcA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		4 / 7 ALA A 219
TYR A 399
ILE A 216
ILE A 214
 None
 0.90A 2zm7A-2ipcA:
undetectable		 2zm7A-2ipcA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		4 / 8 ALA A 219
TYR A 399
ILE A 216
ILE A 214
 None
 0.90A 2zm8A-2ipcA:
undetectable		 2zm8A-2ipcA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		4 / 8 ALA A 219
TYR A 399
ILE A 216
ILE A 214
 None
 0.89A 2zmaA-2ipcA:
undetectable		 2zmaA-2ipcA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		4 / 6 PHE A 662
GLY A 659
LEU A 585
PRO A 445
 None
 0.88A 3bgdA-2ipcA:
undetectable		 3bgdA-2ipcA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		4 / 7 VAL A 432
ILE A 544
GLY A 543
ARG A 541
 None
 0.87A 3bjwB-2ipcA:
undetectable		 3bjwB-2ipcA:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		4 / 7 VAL A 432
ILE A 544
GLY A 543
ARG A 541
 None
 0.78A 3bjwH-2ipcA:
undetectable		 3bjwH-2ipcA:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		3 / 3 ASN A 176
ASP A 212
GLN A 677
 None
 0.79A 3eeyC-2ipcA:
2.5		 3eeyC-2ipcA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		3 / 3 ASN A 176
ASP A 212
GLN A 677
 None
 0.78A 3eeyD-2ipcA:
2.6		 3eeyD-2ipcA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		3 / 3 ASN A 176
ASP A 212
GLN A 677
 None
 0.78A 3eeyE-2ipcA:
2.8		 3eeyE-2ipcA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		4 / 7 PHE A 934
VAL A 789
LEU A 796
SER A 795
 None
 0.82A 3hs6B-2ipcA:
1.4		 3hs6B-2ipcA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		5 / 12 ILE A  96
GLY A 383
ALA A 109
ALA A 206
VAL A 211
 None
 0.87A 3jb2A-2ipcA:
undetectable		 3jb2A-2ipcA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		4 / 4 PRO A 445
LEU A 661
ILE A 583
ARG A 681
 None
 1.33A 3w1wA-2ipcA:
3.6		 3w1wA-2ipcA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		4 / 6 ILE A 663
LEU A 678
ARG A 684
THR A 581
 None
 0.92A 3wg7A-2ipcA:
0.2
3wg7J-2ipcA:
undetectable		 3wg7A-2ipcA:
18.02
3wg7J-2ipcA:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_B_CAMB423_0
(CYTOCHROME P450)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		5 / 10 LEU A 111
GLY A  88
VAL A  24
ASP A  82
VAL A  27
 None
 1.36A 4c9pB-2ipcA:
undetectable		 4c9pB-2ipcA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		3 / 3 ASP A 416
VAL A 420
ASN A 676
 None
 0.67A 4lmnA-2ipcA:
undetectable		 4lmnA-2ipcA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJH_A_SAMA302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		5 / 12 GLU A 742
THR A 390
GLU A  98
GLU A 391
GLN A 738
 None
 1.45A 4njhA-2ipcA:
0.5		 4njhA-2ipcA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJH_B_SAMB302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		5 / 12 GLU A 742
THR A 390
GLU A  98
GLU A 391
GLN A 738
 None
 1.46A 4njhB-2ipcA:
0.5		 4njhB-2ipcA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJI_A_SAMA302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		5 / 12 GLU A 742
THR A 390
GLU A  98
GLU A 391
GLN A 738
 None
 1.47A 4njiA-2ipcA:
0.5		 4njiA-2ipcA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJI_B_SAMB302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		5 / 12 GLU A 742
THR A 390
GLU A  98
GLU A 391
GLN A 738
 None
 1.48A 4njiB-2ipcA:
0.0		 4njiB-2ipcA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJK_A_SAMA302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		5 / 12 GLU A 742
THR A 390
GLU A  98
GLU A 391
GLN A 738
 None
 1.48A 4njkA-2ipcA:
0.4		 4njkA-2ipcA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJK_B_SAMB302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		5 / 12 GLU A 742
THR A 390
GLU A  98
GLU A 391
GLN A 738
 None
 1.47A 4njkB-2ipcA:
0.5		 4njkB-2ipcA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		4 / 8 MET A 616
PHE A 612
ALA A 595
LEU A 596
 None
 1.00A 4rkuA-2ipcA:
1.6
4rkuJ-2ipcA:
undetectable		 4rkuA-2ipcA:
21.51
4rkuJ-2ipcA:
4.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		3 / 3 VAL A 929
LEU A 933
VAL A 873
 None
 0.56A 4wq4A-2ipcA:
undetectable		 4wq4A-2ipcA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		3 / 3 ASP A 905
ARG A 336
ARG A 341
 None
 0.96A 4x5iA-2ipcA:
undetectable		 4x5iA-2ipcA:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		4 / 7 MET A 616
PHE A 612
ALA A 595
LEU A 596
 None
 1.05A 4xk8A-2ipcA:
undetectable		 4xk8A-2ipcA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		4 / 6 PHE A 612
LEU A 592
ASN A 588
PRO A 589
 None
 1.41A 4yv5A-2ipcA:
undetectable		 4yv5A-2ipcA:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		5 / 12 LEU A 661
GLY A 689
GLY A 659
GLY A 660
PRO A 445
 None
 1.08A 4yvgA-2ipcA:
undetectable		 4yvgA-2ipcA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		4 / 8 ILE A 664
GLY A 665
PHE A 697
ASP A 419
 None
 0.93A 5hieD-2ipcA:
undetectable		 5hieD-2ipcA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		5 / 12 VAL A 128
GLU A 210
SER A 213
THR A 450
GLY A 578
 None
 1.41A 5m50B-2ipcA:
undetectable		 5m50B-2ipcA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		5 / 12 VAL A 128
GLU A 210
SER A 213
THR A 450
GLY A 578
 None
 1.35A 5m50E-2ipcA:
1.8		 5m50E-2ipcA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		3 / 3 LYS A 121
HIS A 204
HIS A 201
 None
 1.41A 5oexB-2ipcA:
undetectable		 5oexB-2ipcA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		5 / 12 LEU A 661
GLY A 689
GLY A 659
GLY A 660
PRO A 445
 None
 1.07A 5wyqA-2ipcA:
undetectable		 5wyqA-2ipcA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		6 / 12 LEU A 661
GLY A 689
LEU A 658
GLY A 659
GLY A 660
PRO A 445
 None
 1.29A 5wyqB-2ipcA:
undetectable		 5wyqB-2ipcA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_2
(-)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		5 / 12 LEU A 585
GLY A 686
GLY A 683
GLY A 680
ARG A 679
 None
 1.14A 6ce2B-2ipcA:
undetectable		 6ce2B-2ipcA:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA807_0
(GEPHYRIN)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		4 / 4 PRO A 466
LEU A 463
VAL A 539
ARG A 541
 None
 1.34A 6fgdA-2ipcA:
undetectable		 6fgdA-2ipcA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		5 / 12 GLY A 383
LEU A  91
GLY A  94
ASP A 217
ILE A 216
 None
 1.05A 6mhtA-2ipcA:
undetectable		 6mhtA-2ipcA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT
(Thermus
thermophilus) 		4 / 6 ILE A 663
LEU A 678
ARG A 684
THR A 581
 None
 1.09A 6nmfN-2ipcA:
0.6
6nmfW-2ipcA:
undetectable		 6nmfN-2ipcA:
18.02
6nmfW-2ipcA:
4.55