SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iph'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2iph THIOL PROTEASE P3C
(Norwalk
virus) 		4 / 5 THR A1027
THR A1056
THR A1034
HIS A1030
 None
None
None
LGG  A   1 (-4.2A)
 1.28A 1d4fB-2iphA:
undetectable		 1d4fB-2iphA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_2_BO221405_1
(PROTEASOME COMPONENT
PRE3)		 2iph THIOL PROTEASE P3C
(Norwalk
virus) 		5 / 11 THR A1028
THR A1027
THR A1056
GLY A1155
ALA A1170
 None
 1.16A 2f162-2iphA:
undetectable		 2f162-2iphA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 2iph THIOL PROTEASE P3C
(Norwalk
virus) 		5 / 11 THR A1028
THR A1027
THR A1056
GLY A1155
ALA A1170
 None
 1.15A 2f16N-2iphA:
undetectable		 2f16N-2iphA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 2iph THIOL PROTEASE P3C
(Norwalk
virus) 		5 / 10 VAL A1156
VAL A1009
TRP A1019
ILE A1032
GLY A1140
 None
 1.33A 3km6A-2iphA:
undetectable		 3km6A-2iphA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_2_BO221405_1
(PROTEASOME COMPONENT
PRE3
PROTEASOME COMPONENT
PUP1)		 2iph THIOL PROTEASE P3C
(Norwalk
virus) 		5 / 12 THR A1028
THR A1027
THR A1056
GLY A1155
ALA A1170
 None
 1.20A 3mg02-2iphA:
undetectable
3mg0V-2iphA:
undetectable		 3mg02-2iphA:
23.00
3mg0V-2iphA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 2iph THIOL PROTEASE P3C
(Norwalk
virus) 		5 / 11 THR A1028
THR A1027
THR A1056
GLY A1155
ALA A1170
 None
 1.20A 3mg0N-2iphA:
undetectable		 3mg0N-2iphA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1106_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2iph THIOL PROTEASE P3C
(Norwalk
virus) 		5 / 11 SER A1014
PHE A1012
PHE A1058
ALA A1052
GLN A1172
 None
 1.21A 4dx7A-2iphA:
undetectable		 4dx7A-2iphA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2iph THIOL PROTEASE P3C
(Norwalk
virus) 		5 / 12 THR A1028
THR A1027
THR A1056
GLY A1155
ALA A1170
 None
 1.20A 4qvnV-2iphA:
undetectable
4qvnb-2iphA:
undetectable		 4qvnV-2iphA:
22.76
4qvnb-2iphA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2iph THIOL PROTEASE P3C
(Norwalk
virus) 		5 / 12 THR A1028
THR A1027
THR A1056
GLY A1155
ALA A1170
 None
 1.19A 4qvnH-2iphA:
undetectable
4qvnN-2iphA:
undetectable		 4qvnH-2iphA:
22.76
4qvnN-2iphA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2iph THIOL PROTEASE P3C
(Norwalk
virus) 		5 / 11 THR A1028
THR A1027
THR A1056
GLY A1155
ALA A1170
 None
 1.21A 4qvpV-2iphA:
undetectable
4qvpb-2iphA:
undetectable		 4qvpV-2iphA:
22.76
4qvpb-2iphA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2iph THIOL PROTEASE P3C
(Norwalk
virus) 		5 / 11 THR A1028
THR A1027
THR A1056
GLY A1155
ALA A1170
 None
 1.20A 4qvpH-2iphA:
undetectable
4qvpN-2iphA:
undetectable		 4qvpH-2iphA:
22.76
4qvpN-2iphA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2iph THIOL PROTEASE P3C
(Norwalk
virus) 		5 / 11 THR A1028
THR A1027
THR A1056
GLY A1155
ALA A1170
 None
 1.20A 4qvqV-2iphA:
undetectable
4qvqb-2iphA:
undetectable		 4qvqV-2iphA:
22.76
4qvqb-2iphA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2iph THIOL PROTEASE P3C
(Norwalk
virus) 		5 / 11 THR A1028
THR A1027
THR A1056
GLY A1155
ALA A1170
 None
 1.20A 4qvqH-2iphA:
undetectable
4qvqN-2iphA:
undetectable		 4qvqH-2iphA:
22.76
4qvqN-2iphA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2iph THIOL PROTEASE P3C
(Norwalk
virus) 		5 / 11 THR A1028
THR A1027
THR A1056
GLY A1155
ALA A1170
 None
 1.20A 4qw1V-2iphA:
undetectable
4qw1b-2iphA:
undetectable		 4qw1V-2iphA:
22.76
4qw1b-2iphA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2iph THIOL PROTEASE P3C
(Norwalk
virus) 		5 / 11 THR A1028
THR A1027
THR A1056
GLY A1155
ALA A1170
 None
 1.19A 4qw1H-2iphA:
undetectable
4qw1N-2iphA:
undetectable		 4qw1H-2iphA:
22.76
4qw1N-2iphA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2iph THIOL PROTEASE P3C
(Norwalk
virus) 		5 / 11 THR A1028
THR A1027
THR A1056
GLY A1155
ALA A1170
 None
 1.19A 4qwuV-2iphA:
undetectable
4qwub-2iphA:
undetectable		 4qwuV-2iphA:
22.76
4qwub-2iphA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2iph THIOL PROTEASE P3C
(Norwalk
virus) 		5 / 11 THR A1028
THR A1027
THR A1056
GLY A1155
ALA A1170
 None
 1.19A 4qwuH-2iphA:
undetectable
4qwuN-2iphA:
undetectable		 4qwuH-2iphA:
22.76
4qwuN-2iphA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2iph THIOL PROTEASE P3C
(Norwalk
virus) 		5 / 11 THR A1028
THR A1027
THR A1056
GLY A1155
ALA A1170
 None
 1.20A 5bxnV-2iphA:
undetectable
5bxnb-2iphA:
undetectable		 5bxnV-2iphA:
22.50
5bxnb-2iphA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2iph THIOL PROTEASE P3C
(Norwalk
virus) 		5 / 11 THR A1028
THR A1027
THR A1056
GLY A1155
ALA A1170
 None
 1.20A 5bxnH-2iphA:
undetectable
5bxnN-2iphA:
undetectable		 5bxnH-2iphA:
22.50
5bxnN-2iphA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2iph THIOL PROTEASE P3C
(Norwalk
virus) 		5 / 11 THR A1028
THR A1027
THR A1056
GLY A1155
ALA A1170
 None
 1.21A 5cz7H-2iphA:
undetectable
5cz7N-2iphA:
undetectable		 5cz7H-2iphA:
22.76
5cz7N-2iphA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2iph THIOL PROTEASE P3C
(Norwalk
virus) 		4 / 6 VAL A1153
ARG A1059
ILE A1047
PHE A1060
 None
 0.90A 5jw1A-2iphA:
undetectable		 5jw1A-2iphA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2iph THIOL PROTEASE P3C
(Norwalk
virus) 		4 / 6 VAL A1153
ARG A1059
ILE A1047
PHE A1060
 None
 0.80A 5jw1B-2iphA:
undetectable		 5jw1B-2iphA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2iph THIOL PROTEASE P3C
(Norwalk
virus) 		3 / 3 ARG A1059
ILE A1047
PHE A1060
 None
 0.57A 5kirA-2iphA:
undetectable		 5kirA-2iphA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2iph THIOL PROTEASE P3C
(Norwalk
virus) 		5 / 12 THR A1028
THR A1027
THR A1056
GLY A1155
ALA A1170
 None
 1.21A 5l5zV-2iphA:
undetectable
5l5zb-2iphA:
undetectable		 5l5zV-2iphA:
22.76
5l5zb-2iphA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2iph THIOL PROTEASE P3C
(Norwalk
virus) 		5 / 12 THR A1028
THR A1027
THR A1056
GLY A1155
ALA A1170
 None
 1.21A 5l5zH-2iphA:
undetectable
5l5zN-2iphA:
undetectable		 5l5zH-2iphA:
22.76
5l5zN-2iphA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2iph THIOL PROTEASE P3C
(Norwalk
virus) 		5 / 11 THR A1028
THR A1027
THR A1056
GLY A1155
ALA A1170
 None
 1.21A 5l66V-2iphA:
undetectable
5l66b-2iphA:
undetectable		 5l66V-2iphA:
22.76
5l66b-2iphA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2iph THIOL PROTEASE P3C
(Norwalk
virus) 		5 / 11 THR A1028
THR A1027
THR A1056
GLY A1155
ALA A1170
 None
 1.21A 5l66H-2iphA:
undetectable
5l66N-2iphA:
undetectable		 5l66H-2iphA:
22.76
5l66N-2iphA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_B_BO2B305_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 2iph THIOL PROTEASE P3C
(Norwalk
virus) 		5 / 12 THR A1028
THR A1027
THR A1056
GLY A1155
ALA A1170
 None
 1.18A 5lf3b-2iphA:
undetectable		 5lf3b-2iphA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_N_BO2N304_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 2iph THIOL PROTEASE P3C
(Norwalk
virus) 		5 / 12 THR A1028
THR A1027
THR A1056
GLY A1155
ALA A1170
 None
 1.18A 5lf3N-2iphA:
undetectable		 5lf3N-2iphA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 2iph THIOL PROTEASE P3C
(Norwalk
virus) 		5 / 12 THR A1028
THR A1027
THR A1056
GLY A1155
ALA A1170
 None
 1.16A 5lf7V-2iphA:
undetectable
5lf7b-2iphA:
undetectable		 5lf7V-2iphA:
22.41
5lf7b-2iphA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 2iph THIOL PROTEASE P3C
(Norwalk
virus) 		5 / 12 THR A1028
THR A1027
THR A1056
GLY A1155
ALA A1170
 None
 1.16A 5lf7H-2iphA:
undetectable
5lf7N-2iphA:
undetectable		 5lf7H-2iphA:
22.41
5lf7N-2iphA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSP_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2iph THIOL PROTEASE P3C
(Norwalk
virus) 		4 / 7 VAL A1085
ILE A1087
ASP A1138
ALA A1141
 None
 0.77A 5ospA-2iphA:
undetectable		 5ospA-2iphA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 2iph THIOL PROTEASE P3C
(Norwalk
virus) 		5 / 12 LEU A1180
GLY A1015
PHE A1039
ILE A1049
GLY A1140
 None
 1.00A 5veuH-2iphA:
undetectable		 5veuH-2iphA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJS_A_SALA603_0
(VICILIN-LIKE
ANTIMICROBIAL
PEPTIDES 2-2)		 2iph THIOL PROTEASE P3C
(Norwalk
virus) 		5 / 11 PHE A1025
GLY A1017
VAL A1156
PHE A1055
GLY A1140
 None
 1.45A 5yjsA-2iphA:
undetectable		 5yjsA-2iphA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_B_BO2B201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 2iph THIOL PROTEASE P3C
(Norwalk
virus) 		5 / 12 THR A1028
THR A1027
THR A1056
GLY A1155
ALA A1170
 None
 1.20A 6hwdV-2iphA:
undetectable
6hwdb-2iphA:
undetectable		 6hwdV-2iphA:
18.89
6hwdb-2iphA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_N_BO2N201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 2iph THIOL PROTEASE P3C
(Norwalk
virus) 		5 / 12 THR A1028
THR A1027
THR A1056
GLY A1155
ALA A1170
 None
 1.20A 6hwdH-2iphA:
undetectable
6hwdN-2iphA:
undetectable		 6hwdH-2iphA:
18.89
6hwdN-2iphA:
21.84