SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ipi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQU_A_ESTA304_1
(ESTROGEN
SULFOTRANSFERASE)		 2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)
(Streptomyces
galilaeus) 		5 / 11 CYH A 130
HIS A 138
SER A 376
TYR A 378
GLU A 374
 FAD  A 801 (-1.7A)
FAD  A 801 (-3.6A)
None
AKY  A 601 (-4.5A)
AKY  A 601 ( 4.6A)
 1.46A 1aquA-2ipiA:
0.0
1aquB-2ipiA:
0.0		 1aquA-2ipiA:
18.30
1aquB-2ipiA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)
(Streptomyces
galilaeus) 		3 / 3 VAL A 161
VAL A 175
TRP A 207
 None
 0.91A 1bdwA-2ipiA:
undetectable
1bdwB-2ipiA:
undetectable		 1bdwA-2ipiA:
5.41
1bdwB-2ipiA:
5.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE2_0
(ACTINOMYCIN D)		 2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)
(Streptomyces
galilaeus) 		3 / 3 THR A 392
PRO A 388
THR A 390
 None
 0.84A 1i3wE-2ipiA:
undetectable		 1i3wE-2ipiA:
2.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG2_0
(ACTINOMYCIN D)		 2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)
(Streptomyces
galilaeus) 		3 / 3 THR A 392
PRO A 388
THR A 390
 None
 0.87A 1i3wG-2ipiA:
undetectable		 1i3wG-2ipiA:
2.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)
(Streptomyces
galilaeus) 		5 / 11 GLY A 194
GLY A 195
VAL A 482
LEU A 479
LEU A 158
 None
 1.10A 1mx1A-2ipiA:
undetectable		 1mx1A-2ipiA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)
(Streptomyces
galilaeus) 		4 / 6 LEU A 140
GLY A 136
SER A  67
ILE A 202
 None
FAD  A 801 ( 4.0A)
FAD  A 801 (-2.7A)
FAD  A 801 ( 4.8A)
 0.89A 1yajF-2ipiA:
undetectable		 1yajF-2ipiA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)
(Streptomyces
galilaeus) 		3 / 3 ARG A  27
VAL A  49
GLY A 201
 None
 0.57A 2avvE-2ipiA:
undetectable		 2avvE-2ipiA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)
(Streptomyces
galilaeus) 		5 / 12 MET A  57
ALA A  56
VAL A 164
ASN A  54
ILE A  63
 None
 1.41A 2dcfA-2ipiA:
undetectable		 2dcfA-2ipiA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)
(Streptomyces
galilaeus) 		3 / 3 VAL A 453
ASP A 454
GLU A  73
 None
 0.53A 2qeuA-2ipiA:
undetectable		 2qeuA-2ipiA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)
(Streptomyces
galilaeus) 		3 / 3 VAL A 453
ASP A 454
GLU A  73
 None
 0.53A 2qeuC-2ipiA:
undetectable		 2qeuC-2ipiA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)
(Streptomyces
galilaeus) 		4 / 8 HIS A 253
SER A 272
ILE A 288
HIS A 257
 None
 0.90A 2xadA-2ipiA:
undetectable		 2xadA-2ipiA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)
(Streptomyces
galilaeus) 		4 / 8 HIS A 253
SER A 272
ILE A 288
HIS A 257
 None
 0.91A 2xadB-2ipiA:
undetectable		 2xadB-2ipiA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)
(Streptomyces
galilaeus) 		4 / 8 HIS A 253
SER A 272
ILE A 288
HIS A 257
 None
 0.89A 2xadC-2ipiA:
undetectable		 2xadC-2ipiA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)
(Streptomyces
galilaeus) 		4 / 8 HIS A 253
SER A 272
ILE A 288
HIS A 257
 None
 0.90A 2xadD-2ipiA:
undetectable		 2xadD-2ipiA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)
(Streptomyces
galilaeus) 		4 / 8 GLY A  31
ASN A  30
ILE A 422
VAL A 453
 None
 0.90A 2yoeB-2ipiA:
undetectable
2yoeC-2ipiA:
undetectable		 2yoeB-2ipiA:
19.77
2yoeC-2ipiA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)
(Streptomyces
galilaeus) 		5 / 9 ALA A  83
VAL A  40
VAL A  81
GLY A  35
ALA A  64
 None
 0.87A 2z0yA-2ipiA:
undetectable		 2z0yA-2ipiA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)
(Streptomyces
galilaeus) 		5 / 12 MET A  57
ALA A  56
VAL A 164
ASN A  54
ILE A  63
 None
 1.39A 3a65A-2ipiA:
undetectable		 3a65A-2ipiA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)
(Streptomyces
galilaeus) 		4 / 8 VAL A 175
ILE A  63
VAL A 491
GLY A 201
 None
 0.69A 3hjoB-2ipiA:
undetectable		 3hjoB-2ipiA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)
(Streptomyces
galilaeus) 		5 / 12 ILE A 429
PHE A 430
ALA A 359
THR A 360
ILE A 425
 None
 1.18A 3ndiA-2ipiA:
undetectable		 3ndiA-2ipiA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)
(Streptomyces
galilaeus) 		3 / 3 TYR A 378
TYR A 450
GLU A 374
 AKY  A 601 (-4.5A)
AKY  A 601 (-4.4A)
AKY  A 601 ( 4.6A)
 0.92A 3pfgA-2ipiA:
undetectable		 3pfgA-2ipiA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RLB_B_VIBB187_1
(THIT)		 2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)
(Streptomyces
galilaeus) 		5 / 12 ILE A 429
GLU A 428
HIS A 364
GLY A 373
VAL A 375
 None
 1.26A 3rlbB-2ipiA:
undetectable		 3rlbB-2ipiA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)
(Streptomyces
galilaeus) 		5 / 11 THR A 446
GLY A 445
PRO A 439
PRO A 437
ASP A 452
 None
 1.47A 3t8nD-2ipiA:
0.0
3t8nF-2ipiA:
0.0		 3t8nD-2ipiA:
12.48
3t8nF-2ipiA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_D_C2FD1200_0
(GLYCINE
N-METHYLTRANSFERASE)		 2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)
(Streptomyces
galilaeus) 		5 / 12 LEU A 496
HIS A 494
TYR A 471
LEU A 455
THR A 469
 None
FAD  A 801 ( 4.7A)
None
None
None
 1.37A 3thrA-2ipiA:
0.0
3thrB-2ipiA:
0.3
3thrC-2ipiA:
0.0
3thrD-2ipiA:
0.0		 3thrA-2ipiA:
19.89
3thrB-2ipiA:
19.89
3thrC-2ipiA:
19.89
3thrD-2ipiA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_2
(HIV-1 PROTEASE)		 2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)
(Streptomyces
galilaeus) 		4 / 7 VAL A  65
GLY A 198
VAL A 165
VAL A 163
 FAD  A 801 (-4.6A)
FAD  A 801 (-4.1A)
None
None
 0.80A 3ufnB-2ipiA:
undetectable		 3ufnB-2ipiA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_0
(MNMC2)		 2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)
(Streptomyces
galilaeus) 		6 / 12 GLY A 194
GLY A 143
TYR A 144
ASN A 449
ALA A 191
LEU A 479
 None
FAD  A 801 (-2.9A)
FAD  A 801 (-4.5A)
FAD  A 801 (-3.5A)
None
None
 1.49A 3vywC-2ipiA:
undetectable		 3vywC-2ipiA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)
(Streptomyces
galilaeus) 		4 / 8 GLY A 296
ALA A 297
PRO A 226
THR A 227
 None
 0.80A 4eyrB-2ipiA:
undetectable		 4eyrB-2ipiA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)
(Streptomyces
galilaeus) 		3 / 3 ASP A  18
ARG A  19
ASP A  23
 None
 0.84A 4fp9D-2ipiA:
undetectable		 4fp9D-2ipiA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)
(Streptomyces
galilaeus) 		4 / 8 PRO A 126
SER A 379
SER A 261
ASP A 151
 None
 1.10A 4ndnA-2ipiA:
undetectable		 4ndnA-2ipiA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)
(Streptomyces
galilaeus) 		4 / 8 THR A 336
THR A 408
GLY A  31
ASP A 415
 AKY  A 601 (-4.5A)
AKY  A 601 (-2.8A)
None
None
 0.80A 4qvvK-2ipiA:
undetectable
4qvvL-2ipiA:
undetectable		 4qvvK-2ipiA:
16.70
4qvvL-2ipiA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)
(Streptomyces
galilaeus) 		4 / 8 THR A 336
THR A 408
GLY A  31
ASP A 415
 AKY  A 601 (-4.5A)
AKY  A 601 (-2.8A)
None
None
 0.82A 4qvvY-2ipiA:
undetectable
4qvvZ-2ipiA:
undetectable		 4qvvY-2ipiA:
16.70
4qvvZ-2ipiA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)
(Streptomyces
galilaeus) 		5 / 12 SER A 376
THR A 342
THR A 408
ALA A 407
TYR A 450
 None
AKY  A 601 ( 4.7A)
AKY  A 601 (-2.8A)
None
AKY  A 601 (-4.4A)
 1.05A 4u15B-2ipiA:
undetectable		 4u15B-2ipiA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)
(Streptomyces
galilaeus) 		4 / 7 THR A 329
LEU A 330
LEU A 326
THR A 113
 None
 0.93A 4z90A-2ipiA:
undetectable
4z90B-2ipiA:
undetectable
4z90C-2ipiA:
undetectable
4z90D-2ipiA:
undetectable
4z90E-2ipiA:
undetectable		 4z90A-2ipiA:
20.72
4z90B-2ipiA:
20.72
4z90C-2ipiA:
20.72
4z90D-2ipiA:
20.72
4z90E-2ipiA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)		 2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)
(Streptomyces
galilaeus) 		4 / 7 TRP A 325
THR A 229
PRO A 226
THR A 227
 None
 1.32A 5b6iA-2ipiA:
undetectable		 5b6iA-2ipiA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)
(Streptomyces
galilaeus) 		4 / 5 HIS A 138
VAL A 104
GLY A 107
ALA A 108
 FAD  A 801 (-3.6A)
None
None
None
 0.99A 5hwaA-2ipiA:
undetectable		 5hwaA-2ipiA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)
(Streptomyces
galilaeus) 		5 / 12 GLY A 195
GLY A 107
PHE A 208
GLY A 143
GLY A 142
 None
None
None
FAD  A 801 (-2.9A)
None
 0.91A 5koxA-2ipiA:
undetectable		 5koxA-2ipiA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)
(Streptomyces
galilaeus) 		3 / 3 VAL A  53
ARG A 485
PRO A 488
 None
 0.79A 5koxA-2ipiA:
undetectable		 5koxA-2ipiA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W8A_A_SAMA300_0
(AUTOINDUCER SYNTHASE)		 2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)
(Streptomyces
galilaeus) 		5 / 12 LEU A 349
MET A 405
VAL A 375
ILE A 425
THR A 360
 None
 1.40A 5w8aA-2ipiA:
undetectable		 5w8aA-2ipiA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)
(Streptomyces
galilaeus) 		5 / 12 GLY A  60
GLN A  55
VAL A  14
VAL A  39
ASP A  38
 None
 1.31A 6bxlB-2ipiA:
undetectable		 6bxlB-2ipiA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)
(Streptomyces
galilaeus) 		5 / 12 ASP A 156
GLY A 382
GLY A 152
ARG A 397
SER A 399
 None
 1.20A 6clxA-2ipiA:
undetectable		 6clxA-2ipiA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)
(Streptomyces
galilaeus) 		4 / 8 TYR A 118
TRP A 325
THR A 229
LEU A 147
 None
 0.88A 6cnjD-2ipiA:
undetectable
6cnjE-2ipiA:
undetectable		 6cnjD-2ipiA:
9.00
6cnjE-2ipiA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)
(Streptomyces
galilaeus) 		5 / 12 GLY A 141
GLY A 196
GLN A 396
VAL A 498
GLY A 198
 None
None
None
None
FAD  A 801 (-4.1A)
 1.12A 6gneA-2ipiA:
undetectable		 6gneA-2ipiA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)
(Streptomyces
galilaeus) 		5 / 12 GLY A 141
GLY A 196
GLN A 396
VAL A 498
GLY A 198
 None
None
None
None
FAD  A 801 (-4.1A)
 1.12A 6gneB-2ipiA:
undetectable		 6gneB-2ipiA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_1
(-)		 2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)
(Streptomyces
galilaeus) 		5 / 10 LEU A 301
TYR A 267
SER A 259
HIS A 232
VAL A 318
 None
 1.41A 6gnfC-2ipiA:
undetectable		 6gnfC-2ipiA:
22.73