SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ipx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN
(Homo
sapiens) 		5 / 12 GLY A 168
ALA A 170
SER A 171
ALA A 218
GLN A 240
 MTA  A4001 (-3.3A)
MTA  A4001 (-3.6A)
None
MTA  A4001 (-3.4A)
MTA  A4001 (-4.0A)
 1.07A 1nt2A-2ipxA:
27.5		 1nt2A-2ipxA:
43.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN
(Homo
sapiens) 		5 / 12 LYS A 144
TYR A 166
THR A 174
SER A 194
GLN A 240
 None
None
None
None
MTA  A4001 (-4.0A)
 1.13A 1nt2A-2ipxA:
27.5		 1nt2A-2ipxA:
43.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN
(Homo
sapiens) 		8 / 12 TYR A 166
GLY A 168
ALA A 170
THR A 174
SER A 194
ALA A 218
ASP A 237
GLN A 240
 None
MTA  A4001 (-3.3A)
MTA  A4001 (-3.6A)
None
None
MTA  A4001 (-3.4A)
MTA  A4001 (-4.3A)
MTA  A4001 (-4.0A)
 0.85A 1nt2A-2ipxA:
27.5		 1nt2A-2ipxA:
43.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN
(Homo
sapiens) 		3 / 3 THR A 173
GLU A 192
ASP A 217
 None
MTA  A4001 (-2.7A)
MTA  A4001 (-3.4A)
 0.23A 1nt2A-2ipxA:
27.5		 1nt2A-2ipxA:
43.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN
(Homo
sapiens) 		5 / 8 ASP A 232
ALA A 162
ILE A 158
ILE A 181
GLY A 183
 None
 1.48A 1sh9A-2ipxA:
undetectable		 1sh9A-2ipxA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN
(Homo
sapiens) 		3 / 3 GLY A 168
GLU A 192
ASP A 237
 MTA  A4001 (-3.3A)
MTA  A4001 (-2.7A)
MTA  A4001 (-4.3A)
 0.29A 2b25B-2ipxA:
14.6		 2b25B-2ipxA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN
(Homo
sapiens) 		3 / 3 GLU A 283
GLN A 240
ARG A 219
 None
MTA  A4001 (-4.0A)
MTA  A4001 (-3.9A)
 0.61A 2w3bB-2ipxA:
undetectable		 2w3bB-2ipxA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN
(Homo
sapiens) 		3 / 3 ASP A 217
THR A 174
GLU A 192
 MTA  A4001 (-3.4A)
None
MTA  A4001 (-2.7A)
 0.68A 2zifB-2ipxA:
3.4		 2zifB-2ipxA:
21.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN
(Homo
sapiens) 		8 / 11 TYR A 166
GLY A 168
THR A 174
GLU A 192
ASP A 217
ALA A 218
ASP A 237
GLN A 240
 None
MTA  A4001 (-3.3A)
None
MTA  A4001 (-2.7A)
MTA  A4001 (-3.4A)
MTA  A4001 (-3.4A)
MTA  A4001 (-4.3A)
MTA  A4001 (-4.0A)
 0.70A 3id5B-2ipxA:
31.8		 3id5B-2ipxA:
44.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN
(Homo
sapiens) 		8 / 11 TYR A 166
GLY A 168
THR A 174
GLU A 192
ASP A 217
ALA A 218
ASP A 237
GLN A 240
 None
MTA  A4001 (-3.3A)
None
MTA  A4001 (-2.7A)
MTA  A4001 (-3.4A)
MTA  A4001 (-3.4A)
MTA  A4001 (-4.3A)
MTA  A4001 (-4.0A)
 0.70A 3id5F-2ipxA:
31.8		 3id5F-2ipxA:
44.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN
(Homo
sapiens) 		5 / 12 PHE A 193
SER A 194
ASP A 217
ALA A 218
GLN A 240
 MTA  A4001 (-3.5A)
None
MTA  A4001 (-3.4A)
MTA  A4001 (-3.4A)
MTA  A4001 (-4.0A)
 1.06A 3id6C-2ipxA:
26.9		 3id6C-2ipxA:
44.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN
(Homo
sapiens) 		10 / 12 TYR A 166
GLY A 168
ALA A 170
THR A 174
GLU A 192
SER A 194
ASP A 217
ALA A 218
ASP A 237
GLN A 240
 None
MTA  A4001 (-3.3A)
MTA  A4001 (-3.6A)
None
MTA  A4001 (-2.7A)
None
MTA  A4001 (-3.4A)
MTA  A4001 (-3.4A)
MTA  A4001 (-4.3A)
MTA  A4001 (-4.0A)
 0.46A 3id6C-2ipxA:
26.9		 3id6C-2ipxA:
44.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN
(Homo
sapiens) 		4 / 4 GLY A 168
GLU A 192
ASP A 217
ASP A 237
 MTA  A4001 (-3.3A)
MTA  A4001 (-2.7A)
MTA  A4001 (-3.4A)
MTA  A4001 (-4.3A)
 0.38A 3mb5A-2ipxA:
17.6		 3mb5A-2ipxA:
28.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN
(Homo
sapiens) 		5 / 12 ALA A 169
PHE A 193
SER A 194
ASP A 217
ALA A 218
 None
MTA  A4001 (-3.5A)
None
MTA  A4001 (-3.4A)
MTA  A4001 (-3.4A)
 1.31A 3nmuA-2ipxA:
undetectable
3nmuF-2ipxA:
35.6		 3nmuA-2ipxA:
23.00
3nmuF-2ipxA:
49.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN
(Homo
sapiens) 		7 / 12 GLY A 168
ALA A 169
GLU A 192
SER A 194
ASP A 217
ALA A 218
ASP A 237
 MTA  A4001 (-3.3A)
None
MTA  A4001 (-2.7A)
None
MTA  A4001 (-3.4A)
MTA  A4001 (-3.4A)
MTA  A4001 (-4.3A)
 1.42A 3nmuA-2ipxA:
undetectable
3nmuF-2ipxA:
35.6		 3nmuA-2ipxA:
23.00
3nmuF-2ipxA:
49.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN
(Homo
sapiens) 		8 / 12 GLY A 168
ALA A 170
GLU A 192
SER A 194
ASP A 217
ALA A 218
ASP A 237
GLN A 240
 MTA  A4001 (-3.3A)
MTA  A4001 (-3.6A)
MTA  A4001 (-2.7A)
None
MTA  A4001 (-3.4A)
MTA  A4001 (-3.4A)
MTA  A4001 (-4.3A)
MTA  A4001 (-4.0A)
 0.54A 3nmuA-2ipxA:
undetectable
3nmuF-2ipxA:
35.6		 3nmuA-2ipxA:
23.00
3nmuF-2ipxA:
49.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN
(Homo
sapiens) 		5 / 12 LYS A 144
ALA A 170
GLU A 192
SER A 194
GLN A 240
 None
MTA  A4001 (-3.6A)
MTA  A4001 (-2.7A)
None
MTA  A4001 (-4.0A)
 0.83A 3nmuA-2ipxA:
undetectable
3nmuF-2ipxA:
35.6		 3nmuA-2ipxA:
23.00
3nmuF-2ipxA:
49.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN
(Homo
sapiens) 		5 / 12 PHE A 193
SER A 194
ASP A 217
ALA A 218
GLN A 240
 MTA  A4001 (-3.5A)
None
MTA  A4001 (-3.4A)
MTA  A4001 (-3.4A)
MTA  A4001 (-4.0A)
 1.08A 3nmuA-2ipxA:
undetectable
3nmuF-2ipxA:
35.6		 3nmuA-2ipxA:
23.00
3nmuF-2ipxA:
49.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN
(Homo
sapiens) 		6 / 11 GLY A 168
ALA A 170
GLU A 192
ALA A 218
ASP A 237
GLN A 240
 MTA  A4001 (-3.3A)
MTA  A4001 (-3.6A)
MTA  A4001 (-2.7A)
MTA  A4001 (-3.4A)
MTA  A4001 (-4.3A)
MTA  A4001 (-4.0A)
 0.48A 3nmuB-2ipxA:
undetectable
3nmuJ-2ipxA:
35.4		 3nmuB-2ipxA:
23.00
3nmuJ-2ipxA:
49.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN
(Homo
sapiens) 		7 / 12 GLY A 168
ALA A 170
ALA A 218
ASP A 237
VAL A 238
GLN A 240
GLU A 304
 MTA  A4001 (-3.3A)
MTA  A4001 (-3.6A)
MTA  A4001 (-3.4A)
MTA  A4001 (-4.3A)
MTA  A4001 (-4.1A)
MTA  A4001 (-4.0A)
None
 0.68A 3nvkI-2ipxA:
30.9		 3nvkI-2ipxA:
49.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN
(Homo
sapiens) 		7 / 12 GLY A 168
ALA A 170
ASP A 217
ALA A 218
ASP A 237
VAL A 238
GLU A 304
 MTA  A4001 (-3.3A)
MTA  A4001 (-3.6A)
MTA  A4001 (-3.4A)
MTA  A4001 (-3.4A)
MTA  A4001 (-4.3A)
MTA  A4001 (-4.1A)
None
 0.59A 3nvkI-2ipxA:
30.9		 3nvkI-2ipxA:
49.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN
(Homo
sapiens) 		6 / 12 ALA A 170
GLU A 192
PHE A 193
ASP A 217
ALA A 218
GLN A 240
 MTA  A4001 (-3.6A)
MTA  A4001 (-2.7A)
MTA  A4001 (-3.5A)
MTA  A4001 (-3.4A)
MTA  A4001 (-3.4A)
MTA  A4001 (-4.0A)
 1.00A 3nvkF-2ipxA:
undetectable
3nvkJ-2ipxA:
31.0		 3nvkF-2ipxA:
23.24
3nvkJ-2ipxA:
49.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN
(Homo
sapiens) 		8 / 12 LYS A 144
GLY A 168
ALA A 169
GLU A 192
ASP A 217
ASP A 237
VAL A 238
GLN A 240
 None
MTA  A4001 (-3.3A)
None
MTA  A4001 (-2.7A)
MTA  A4001 (-3.4A)
MTA  A4001 (-4.3A)
MTA  A4001 (-4.1A)
MTA  A4001 (-4.0A)
 1.48A 3nvkF-2ipxA:
undetectable
3nvkJ-2ipxA:
31.0		 3nvkF-2ipxA:
23.24
3nvkJ-2ipxA:
49.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN
(Homo
sapiens) 		9 / 12 LYS A 144
GLY A 168
ALA A 170
GLU A 192
ASP A 217
ALA A 218
ASP A 237
VAL A 238
GLN A 240
 None
MTA  A4001 (-3.3A)
MTA  A4001 (-3.6A)
MTA  A4001 (-2.7A)
MTA  A4001 (-3.4A)
MTA  A4001 (-3.4A)
MTA  A4001 (-4.3A)
MTA  A4001 (-4.1A)
MTA  A4001 (-4.0A)
 0.98A 3nvkF-2ipxA:
undetectable
3nvkJ-2ipxA:
31.0		 3nvkF-2ipxA:
23.24
3nvkJ-2ipxA:
49.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN
(Homo
sapiens) 		4 / 5 SER A 171
THR A 173
GLU A 192
ASP A 217
 None
None
MTA  A4001 (-2.7A)
MTA  A4001 (-3.4A)
 1.15A 3tm4A-2ipxA:
14.6		 3tm4A-2ipxA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN
(Homo
sapiens) 		4 / 5 SER A 171
THR A 173
GLU A 192
ASP A 217
 None
None
MTA  A4001 (-2.7A)
MTA  A4001 (-3.4A)
 1.15A 3tm4B-2ipxA:
14.5		 3tm4B-2ipxA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN
(Homo
sapiens) 		5 / 12 GLY A 168
ALA A 170
PHE A 193
VAL A 238
ILE A 246
 MTA  A4001 (-3.3A)
MTA  A4001 (-3.6A)
MTA  A4001 (-3.5A)
MTA  A4001 (-4.1A)
None
 1.07A 4aztA-2ipxA:
10.2		 4aztA-2ipxA:
18.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN
(Homo
sapiens) 		5 / 12 ALA A 170
THR A 174
PHE A 193
ASP A 217
GLN A 240
 MTA  A4001 (-3.6A)
None
MTA  A4001 (-3.5A)
MTA  A4001 (-3.4A)
MTA  A4001 (-4.0A)
 1.30A 4df3A-2ipxA:
28.1		 4df3A-2ipxA:
45.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN
(Homo
sapiens) 		9 / 12 GLY A 168
ALA A 170
THR A 173
PHE A 193
ASP A 217
ALA A 218
ASP A 237
VAL A 238
GLN A 240
 MTA  A4001 (-3.3A)
MTA  A4001 (-3.6A)
None
MTA  A4001 (-3.5A)
MTA  A4001 (-3.4A)
MTA  A4001 (-3.4A)
MTA  A4001 (-4.3A)
MTA  A4001 (-4.1A)
MTA  A4001 (-4.0A)
 0.48A 4df3A-2ipxA:
28.1		 4df3A-2ipxA:
45.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN
(Homo
sapiens) 		3 / 3 TYR A 166
THR A 174
GLU A 192
 None
None
MTA  A4001 (-2.7A)
 0.37A 4df3A-2ipxA:
28.1		 4df3A-2ipxA:
45.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN
(Homo
sapiens) 		5 / 12 ALA A 170
THR A 174
PHE A 193
ASP A 217
GLN A 240
 MTA  A4001 (-3.6A)
None
MTA  A4001 (-3.5A)
MTA  A4001 (-3.4A)
MTA  A4001 (-4.0A)
 1.27A 4df3B-2ipxA:
28.1		 4df3B-2ipxA:
45.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN
(Homo
sapiens) 		9 / 12 GLY A 168
ALA A 170
THR A 173
PHE A 193
ASP A 217
ALA A 218
ASP A 237
VAL A 238
GLN A 240
 MTA  A4001 (-3.3A)
MTA  A4001 (-3.6A)
None
MTA  A4001 (-3.5A)
MTA  A4001 (-3.4A)
MTA  A4001 (-3.4A)
MTA  A4001 (-4.3A)
MTA  A4001 (-4.1A)
MTA  A4001 (-4.0A)
 0.52A 4df3B-2ipxA:
28.1		 4df3B-2ipxA:
45.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN
(Homo
sapiens) 		3 / 3 TYR A 166
THR A 174
GLU A 192
 None
None
MTA  A4001 (-2.7A)
 0.33A 4df3B-2ipxA:
28.1		 4df3B-2ipxA:
45.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN
(Homo
sapiens) 		4 / 5 GLY A 172
SER A 171
ALA A 170
GLU A 192
 None
None
MTA  A4001 (-3.6A)
MTA  A4001 (-2.7A)
 1.00A 4m93B-2ipxA:
undetectable
4m93C-2ipxA:
undetectable		 4m93B-2ipxA:
19.07
4m93C-2ipxA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN
(Homo
sapiens) 		3 / 3 GLU A 134
LYS A 132
ASN A 111
 None
 0.97A 4y1dA-2ipxA:
undetectable
4y1dD-2ipxA:
undetectable		 4y1dA-2ipxA:
21.88
4y1dD-2ipxA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN
(Homo
sapiens) 		4 / 7 GLY A 168
GLU A 192
ASP A 217
ASP A 237
 MTA  A4001 (-3.3A)
MTA  A4001 (-2.7A)
MTA  A4001 (-3.4A)
MTA  A4001 (-4.3A)
 0.58A 5ergB-2ipxA:
15.4		 5ergB-2ipxA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN
(Homo
sapiens) 		4 / 7 ASN A 210
VAL A 188
ALA A 190
GLY A 172
 None
 0.63A 5fpdA-2ipxA:
undetectable		 5fpdA-2ipxA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN
(Homo
sapiens) 		4 / 7 ASN A 210
VAL A 188
ALA A 190
GLY A 172
 None
 0.64A 5fpdB-2ipxA:
1.7		 5fpdB-2ipxA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN
(Homo
sapiens) 		5 / 12 ASP A 217
ALA A 218
ASP A 237
THR A 174
GLU A 192
 MTA  A4001 (-3.4A)
MTA  A4001 (-3.4A)
MTA  A4001 (-4.3A)
None
MTA  A4001 (-2.7A)
 0.92A 5hfjA-2ipxA:
3.7		 5hfjA-2ipxA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN
(Homo
sapiens) 		5 / 12 ASP A 217
ALA A 218
ASP A 237
THR A 173
GLU A 192
 MTA  A4001 (-3.4A)
MTA  A4001 (-3.4A)
MTA  A4001 (-4.3A)
None
MTA  A4001 (-2.7A)
 1.10A 5hfjD-2ipxA:
3.9		 5hfjD-2ipxA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN
(Homo
sapiens) 		5 / 12 ASP A 217
ALA A 218
ASP A 237
THR A 173
GLU A 192
 MTA  A4001 (-3.4A)
MTA  A4001 (-3.4A)
MTA  A4001 (-4.3A)
None
MTA  A4001 (-2.7A)
 1.18A 5hfjE-2ipxA:
3.7		 5hfjE-2ipxA:
21.54