SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iq1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 2iq1 PROTEIN PHOSPHATASE
2C KAPPA, PPM1K
(Homo
sapiens) 		4 / 7 LEU A 201
THR A 191
LEU A 195
VAL A 125
 None
 0.59A 1ictD-2iq1A:
undetectable		 1ictD-2iq1A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 2iq1 PROTEIN PHOSPHATASE
2C KAPPA, PPM1K
(Homo
sapiens) 		5 / 12 ALA A  98
ALA A 341
LEU A 222
GLY A  96
LEU A 293
 None
 1.24A 1qabF-2iq1A:
undetectable		 1qabF-2iq1A:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 2iq1 PROTEIN PHOSPHATASE
2C KAPPA, PPM1K
(Homo
sapiens) 		4 / 7 LEU A 201
THR A 191
LEU A 195
VAL A 125
 None
 0.67A 1tyrB-2iq1A:
undetectable		 1tyrB-2iq1A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2iq1 PROTEIN PHOSPHATASE
2C KAPPA, PPM1K
(Homo
sapiens) 		5 / 12 LEU A 258
LEU A 269
GLY A 265
CYH A 138
ALA A 190
 None
 1.17A 2bm9A-2iq1A:
undetectable		 2bm9A-2iq1A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2iq1 PROTEIN PHOSPHATASE
2C KAPPA, PPM1K
(Homo
sapiens) 		5 / 12 LEU A 258
LEU A 269
GLY A 265
CYH A 138
ALA A 190
 None
 1.15A 2bm9B-2iq1A:
undetectable		 2bm9B-2iq1A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2iq1 PROTEIN PHOSPHATASE
2C KAPPA, PPM1K
(Homo
sapiens) 		5 / 12 LEU A 258
LEU A 269
GLY A 265
CYH A 138
ALA A 190
 None
 1.17A 2bm9C-2iq1A:
undetectable		 2bm9C-2iq1A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2iq1 PROTEIN PHOSPHATASE
2C KAPPA, PPM1K
(Homo
sapiens) 		5 / 12 LEU A 258
LEU A 269
GLY A 265
CYH A 138
ALA A 190
 None
 1.14A 2br4C-2iq1A:
undetectable		 2br4C-2iq1A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_2
(PROTEASE)		 2iq1 PROTEIN PHOSPHATASE
2C KAPPA, PPM1K
(Homo
sapiens) 		6 / 12 LEU A 269
ASP A 266
GLY A 187
GLY A 207
VAL A 206
VAL A 254
 None
 1.47A 2o4lB-2iq1A:
undetectable		 2o4lB-2iq1A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_2
(PROTEASE)		 2iq1 PROTEIN PHOSPHATASE
2C KAPPA, PPM1K
(Homo
sapiens) 		5 / 9 ASP A 208
VAL A 206
ILE A 264
GLY A 187
THR A 261
 None
 1.10A 3el4B-2iq1A:
undetectable		 3el4B-2iq1A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 2iq1 PROTEIN PHOSPHATASE
2C KAPPA, PPM1K
(Homo
sapiens) 		5 / 9 ASP A 109
SER A  99
THR A 327
GLY A 299
ASP A 337
 MG  A   1 ( 4.9A)
None
None
None
MG  A   1 (-3.1A)
 1.40A 3sfuA-2iq1A:
undetectable		 3sfuA-2iq1A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 2iq1 PROTEIN PHOSPHATASE
2C KAPPA, PPM1K
(Homo
sapiens) 		5 / 11 ASP A 109
SER A  99
THR A 327
GLY A 299
ASP A 337
 MG  A   1 ( 4.9A)
None
None
None
MG  A   1 (-3.1A)
 1.41A 3sfuC-2iq1A:
undetectable		 3sfuC-2iq1A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ACTA908_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 2iq1 PROTEIN PHOSPHATASE
2C KAPPA, PPM1K
(Homo
sapiens) 		4 / 4 MET A 260
SER A 263
LEU A 258
VAL A 274
 None
 1.41A 3vlnA-2iq1A:
0.0		 3vlnA-2iq1A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 2iq1 PROTEIN PHOSPHATASE
2C KAPPA, PPM1K
(Homo
sapiens) 		4 / 7 LEU A 201
THR A 191
ALA A 193
LEU A 195
 None
 0.67A 4d7bA-2iq1A:
undetectable		 4d7bA-2iq1A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2iq1 PROTEIN PHOSPHATASE
2C KAPPA, PPM1K
(Homo
sapiens) 		5 / 12 ASP A 127
ASP A 298
ASP A 225
GLY A 207
SER A 263
 MG  A   1 (-2.8A)
MG  A   1 ( 3.6A)
None
None
None
 1.37A 4djeB-2iq1A:
undetectable		 4djeB-2iq1A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 2iq1 PROTEIN PHOSPHATASE
2C KAPPA, PPM1K
(Homo
sapiens) 		4 / 8 LEU A 201
THR A 191
ALA A 193
LEU A 195
 None
 0.62A 4iizB-2iq1A:
undetectable		 4iizB-2iq1A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 2iq1 PROTEIN PHOSPHATASE
2C KAPPA, PPM1K
(Homo
sapiens) 		4 / 8 LEU A 201
THR A 191
ALA A 193
LEU A 195
 None
 0.64A 4ik6B-2iq1A:
undetectable		 4ik6B-2iq1A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 2iq1 PROTEIN PHOSPHATASE
2C KAPPA, PPM1K
(Homo
sapiens) 		4 / 7 LEU A 201
THR A 191
ALA A 193
VAL A 125
 None
 0.83A 4ik7A-2iq1A:
undetectable		 4ik7A-2iq1A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		 2iq1 PROTEIN PHOSPHATASE
2C KAPPA, PPM1K
(Homo
sapiens) 		5 / 12 VAL A 125
ALA A 124
GLY A 207
ASP A 109
THR A 297
 None
None
None
MG  A   1 ( 4.9A)
None
 1.17A 4mm8A-2iq1A:
undetectable		 4mm8A-2iq1A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2iq1 PROTEIN PHOSPHATASE
2C KAPPA, PPM1K
(Homo
sapiens) 		4 / 7 THR A 296
LEU A 295
THR A 223
LEU A 222
 None
 0.89A 4z91F-2iq1A:
undetectable
4z91G-2iq1A:
undetectable
4z91H-2iq1A:
undetectable
4z91I-2iq1A:
undetectable
4z91J-2iq1A:
undetectable		 4z91F-2iq1A:
20.30
4z91G-2iq1A:
20.30
4z91H-2iq1A:
20.30
4z91I-2iq1A:
20.30
4z91J-2iq1A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 2iq1 PROTEIN PHOSPHATASE
2C KAPPA, PPM1K
(Homo
sapiens) 		4 / 4 VAL A 343
ALA A  98
ILE A 300
THR A 327
 None
 1.02A 5e4dB-2iq1A:
undetectable		 5e4dB-2iq1A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 2iq1 PROTEIN PHOSPHATASE
2C KAPPA, PPM1K
(Homo
sapiens) 		5 / 12 LEU A 285
GLY A 198
LEU A 194
GLU A 200
LEU A 156
 None
 1.21A 5nwvA-2iq1A:
undetectable		 5nwvA-2iq1A:
15.79