SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iq7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)		 2iq7 ENDOPOLYGALACTURONAS
E
(Colletotrichum
lupini) 		5 / 9 LEU A 142
ILE A 103
ASN A 140
VAL A 162
GLY A 138
 None
 1.30A 1e7aA-2iq7A:
undetectable		 1e7aA-2iq7A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 2iq7 ENDOPOLYGALACTURONAS
E
(Colletotrichum
lupini) 		4 / 7 PHE A 149
PHE A 125
PHE A  76
HIS A 101
 None
 0.91A 1lh6A-2iq7A:
undetectable		 1lh6A-2iq7A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 2iq7 ENDOPOLYGALACTURONAS
E
(Colletotrichum
lupini) 		5 / 12 ILE A 273
ILE A 241
VAL A 239
VAL A 188
ILE A 190
 None
 1.23A 1r5lA-2iq7A:
undetectable		 1r5lA-2iq7A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2iq7 ENDOPOLYGALACTURONAS
E
(Colletotrichum
lupini) 		3 / 3 ILE A 285
ILE A 325
THR A 257
 None
 0.59A 1rg7A-2iq7A:
undetectable		 1rg7A-2iq7A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1U_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 2iq7 ENDOPOLYGALACTURONAS
E
(Colletotrichum
lupini) 		5 / 10 ILE A 273
VAL A 342
GLY A 282
LEU A 223
TYR A 270
 None
 1.23A 1s1uA-2iq7A:
undetectable		 1s1uA-2iq7A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2iq7 ENDOPOLYGALACTURONAS
E
(Colletotrichum
lupini) 		3 / 3 ASP A 165
ASP A 104
ASN A 197
 None
 0.70A 2bm9D-2iq7A:
undetectable		 2bm9D-2iq7A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 2iq7 ENDOPOLYGALACTURONAS
E
(Colletotrichum
lupini) 		5 / 12 TRP A 111
GLY A 174
GLY A 173
ASN A 166
ASP A 200
 None
 0.96A 2dpmA-2iq7A:
undetectable		 2dpmA-2iq7A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 2iq7 ENDOPOLYGALACTURONAS
E
(Colletotrichum
lupini) 		5 / 9 ASN A 205
ILE A 204
ILE A 151
ASP A 181
GLY A 207
 None
 1.33A 2dtjA-2iq7A:
undetectable
2dtjB-2iq7A:
undetectable		 2dtjA-2iq7A:
17.11
2dtjB-2iq7A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2iq7 ENDOPOLYGALACTURONAS
E
(Colletotrichum
lupini) 		5 / 12 VAL A  51
ALA A  31
LEU A  46
ILE A  35
MET A  59
 None
 1.06A 2h42B-2iq7A:
undetectable		 2h42B-2iq7A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2iq7 ENDOPOLYGALACTURONAS
E
(Colletotrichum
lupini) 		4 / 8 PHE A 126
ILE A 103
PHE A 149
GLY A 138
 None
 0.92A 2qwxA-2iq7A:
undetectable
2qwxB-2iq7A:
undetectable		 2qwxA-2iq7A:
20.58
2qwxB-2iq7A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2iq7 ENDOPOLYGALACTURONAS
E
(Colletotrichum
lupini) 		4 / 8 PHE A 126
ILE A 103
PHE A 149
GLY A 138
 None
 0.90A 2qx4A-2iq7A:
undetectable
2qx4B-2iq7A:
undetectable		 2qx4A-2iq7A:
20.41
2qx4B-2iq7A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 2iq7 ENDOPOLYGALACTURONAS
E
(Colletotrichum
lupini) 		4 / 4 THR A 213
VAL A 159
GLY A 187
THR A 186
 None
 0.93A 3cflA-2iq7A:
undetectable		 3cflA-2iq7A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 2iq7 ENDOPOLYGALACTURONAS
E
(Colletotrichum
lupini) 		5 / 9 ALA A  34
LEU A  57
VAL A  68
ILE A 103
LEU A 139
 None
 1.21A 3jw3B-2iq7A:
undetectable		 3jw3B-2iq7A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 2iq7 ENDOPOLYGALACTURONAS
E
(Colletotrichum
lupini) 		5 / 12 LEU A  46
THR A  69
GLY A  48
GLY A  72
ILE A  44
 None
 1.00A 3nk7A-2iq7A:
undetectable		 3nk7A-2iq7A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 2iq7 ENDOPOLYGALACTURONAS
E
(Colletotrichum
lupini) 		4 / 8 VAL A 302
VAL A 268
ILE A 255
GLN A 287
 None
 0.96A 3remB-2iq7A:
undetectable		 3remB-2iq7A:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2iq7 ENDOPOLYGALACTURONAS
E
(Colletotrichum
lupini) 		4 / 8 PHE A 126
ILE A 103
PHE A 149
GLY A 138
 None
 0.95A 4fgjA-2iq7A:
undetectable
4fgjB-2iq7A:
undetectable		 4fgjA-2iq7A:
20.92
4fgjB-2iq7A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 2iq7 ENDOPOLYGALACTURONAS
E
(Colletotrichum
lupini) 		3 / 3 LYS A  38
LEU A  62
ALA A  39
 None
 0.82A 4iizA-2iq7A:
undetectable		 4iizA-2iq7A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)		 2iq7 ENDOPOLYGALACTURONAS
E
(Colletotrichum
lupini) 		5 / 12 GLY A 220
ASN A 197
ASP A 250
ASN A 248
SER A 319
 None
 1.39A 4pooB-2iq7A:
undetectable		 4pooB-2iq7A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2iq7 ENDOPOLYGALACTURONAS
E
(Colletotrichum
lupini) 		4 / 8 PHE A 126
ILE A 103
PHE A 149
GLY A 138
 None
 0.88A 4qogA-2iq7A:
undetectable
4qogB-2iq7A:
undetectable		 4qogA-2iq7A:
20.58
4qogB-2iq7A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		 2iq7 ENDOPOLYGALACTURONAS
E
(Colletotrichum
lupini) 		4 / 7 VAL A 188
ILE A 190
PHE A 180
VAL A 182
 None
 0.79A 5bmvC-2iq7A:
undetectable		 5bmvC-2iq7A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 2iq7 ENDOPOLYGALACTURONAS
E
(Colletotrichum
lupini) 		5 / 12 VAL A 188
ILE A 190
PHE A 180
VAL A 182
GLY A 183
 None
 0.69A 5j2tC-2iq7A:
undetectable		 5j2tC-2iq7A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2iq7 ENDOPOLYGALACTURONAS
E
(Colletotrichum
lupini) 		4 / 9 ILE A 204
VAL A 188
ASN A 152
ASP A 233
 None
 0.86A 5lg3I-2iq7A:
undetectable		 5lg3I-2iq7A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2iq7 ENDOPOLYGALACTURONAS
E
(Colletotrichum
lupini) 		4 / 6 GLY A 183
ASN A 152
SER A 232
ARG A 231
 None
 1.17A 6dwdA-2iq7A:
undetectable
6dwdC-2iq7A:
undetectable		 6dwdA-2iq7A:
21.68
6dwdC-2iq7A:
21.68