SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iqc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 2iqc FANCONI ANEMIA GROUP
F PROTEIN
(Homo
sapiens) 		3 / 3 LEU A 196
PHE A 201
ARG A 187
 None
 0.71A 1xdkB-2iqcA:
undetectable		 1xdkB-2iqcA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 2iqc FANCONI ANEMIA GROUP
F PROTEIN
(Homo
sapiens) 		3 / 3 LEU A 196
PHE A 201
ARG A 187
 None
 0.71A 1xdkF-2iqcA:
undetectable		 1xdkF-2iqcA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 2iqc FANCONI ANEMIA GROUP
F PROTEIN
(Homo
sapiens) 		5 / 10 ALA A 257
LEU A 275
SER A 313
LEU A 314
LEU A 278
 None
 1.01A 2xn7A-2iqcA:
undetectable
2xn7B-2iqcA:
undetectable		 2xn7A-2iqcA:
21.41
2xn7B-2iqcA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2iqc FANCONI ANEMIA GROUP
F PROTEIN
(Homo
sapiens) 		5 / 12 ILE A 205
GLN A 211
LEU A 210
VAL A 247
LEU A 255
 None
 1.29A 3uvvB-2iqcA:
undetectable		 3uvvB-2iqcA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 2iqc FANCONI ANEMIA GROUP
F PROTEIN
(Homo
sapiens) 		5 / 12 PHE A 201
PHE A 251
LEU A 210
LEU A 259
LEU A 170
 None
 1.07A 4j03A-2iqcA:
undetectable		 4j03A-2iqcA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 2iqc FANCONI ANEMIA GROUP
F PROTEIN
(Homo
sapiens) 		4 / 8 LEU A 260
PHE A 248
LEU A 209
ILE A 205
 None
 0.85A 5mzjA-2iqcA:
undetectable		 5mzjA-2iqcA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 2iqc FANCONI ANEMIA GROUP
F PROTEIN
(Homo
sapiens) 		4 / 6 VAL A 325
LEU A 351
LEU A 354
ARG A 355
 None
 0.91A 6e43A-2iqcA:
undetectable		 6e43A-2iqcA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 2iqc FANCONI ANEMIA GROUP
F PROTEIN
(Homo
sapiens) 		4 / 6 VAL A 325
LEU A 351
LEU A 354
ARG A 355
 None
 0.90A 6e43B-2iqcA:
undetectable		 6e43B-2iqcA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 2iqc FANCONI ANEMIA GROUP
F PROTEIN
(Homo
sapiens) 		4 / 6 VAL A 325
LEU A 351
LEU A 354
ARG A 355
 None
 0.92A 6e43C-2iqcA:
undetectable		 6e43C-2iqcA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 2iqc FANCONI ANEMIA GROUP
F PROTEIN
(Homo
sapiens) 		4 / 6 VAL A 325
LEU A 351
LEU A 354
ARG A 355
 None
 0.85A 6e43D-2iqcA:
undetectable		 6e43D-2iqcA:
19.75