SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iqf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 2iqf CATALASE
(Helicobacter
pylori) 		3 / 3 ASP A 194
GLU A 440
TYR A 175
 None
 0.82A 1wsvA-2iqfA:
undetectable		 1wsvA-2iqfA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 2iqf CATALASE
(Helicobacter
pylori) 		3 / 3 ARG A 335
VAL A 213
GLY A 323
 HEM  A 550 (-3.5A)
None
None
 0.61A 2avvE-2iqfA:
undetectable		 2avvE-2iqfA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBL_A_CAMA517_0
(CYTOCHROME P450-CAM)		 2iqf CATALASE
(Helicobacter
pylori) 		4 / 7 LEU A 174
VAL A 177
THR A 178
VAL A 479
 None
MHO  A 181 ( 4.5A)
None
None
 0.88A 2qblA-2iqfA:
undetectable		 2qblA-2iqfA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2iqf CATALASE
(Helicobacter
pylori) 		5 / 7 VAL A  68
VAL A 294
LEU A 260
SER A 261
TRP A 124
 None
MHO  A 292 ( 4.5A)
None
MHO  A 292 ( 3.9A)
None
 1.18A 3hs6B-2iqfA:
undetectable		 3hs6B-2iqfA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 2iqf CATALASE
(Helicobacter
pylori) 		4 / 8 ARG A 111
ALA A 104
ASP A 238
SER A 241
 None
 1.02A 3qj7A-2iqfA:
undetectable
3qj7D-2iqfA:
undetectable		 3qj7A-2iqfA:
20.38
3qj7D-2iqfA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2iqf CATALASE
(Helicobacter
pylori) 		4 / 7 TRP A 179
PRO A 132
LEU A 291
ILE A 283
 None
None
MHO  A 292 ( 4.1A)
None
 1.04A 3u5jA-2iqfA:
undetectable		 3u5jA-2iqfA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 2iqf CATALASE
(Helicobacter
pylori) 		3 / 3 LYS A  58
THR A  96
ILE A 186
 None
 0.82A 4e0fB-2iqfA:
undetectable		 4e0fB-2iqfA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 2iqf CATALASE
(Helicobacter
pylori) 		4 / 8 PHE A  66
GLY A 295
LEU A 260
ILE A  72
 None
 0.85A 4em2A-2iqfA:
undetectable		 4em2A-2iqfA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 2iqf CATALASE
(Helicobacter
pylori) 		3 / 3 ARG A 101
TYR A 339
ASN A 357
 None
HEM  A 550 (-3.8A)
None
 0.55A 4ffwB-2iqfA:
undetectable		 4ffwB-2iqfA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2iqf CATALASE
(Helicobacter
pylori) 		4 / 5 PRO A 110
ASP A 109
ILE A 146
VAL A 163
 None
None
None
MHO  A 162 ( 3.4A)
 1.45A 4hytA-2iqfA:
undetectable		 4hytA-2iqfA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2iqf CATALASE
(Helicobacter
pylori) 		4 / 4 SER A 338
LEU A 332
TYR A 339
PRO A 143
 HEM  A 550 (-3.3A)
None
HEM  A 550 (-3.8A)
None
 1.49A 4jksB-2iqfA:
undetectable		 4jksB-2iqfA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 2iqf CATALASE
(Helicobacter
pylori) 		4 / 9 TYR A 117
PHE A  81
PHE A 217
ILE A 296
 None
 1.17A 4jvlA-2iqfA:
undetectable		 4jvlA-2iqfA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_B_ESTB302_1
(ESTROGEN
SULFOTRANSFERASE)		 2iqf CATALASE
(Helicobacter
pylori) 		5 / 9 TYR A 117
PHE A  81
LYS A  87
PHE A 217
ILE A 296
 None
 1.34A 4jvlB-2iqfA:
0.0		 4jvlB-2iqfA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2iqf CATALASE
(Helicobacter
pylori) 		4 / 4 SER A 338
LEU A 332
TYR A 339
PRO A 143
 HEM  A 550 (-3.3A)
None
HEM  A 550 (-3.8A)
None
 1.50A 4kalB-2iqfA:
0.0		 4kalB-2iqfA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 2iqf CATALASE
(Helicobacter
pylori) 		3 / 3 TYR A 418
GLN A 333
TRP A 416
 None
 1.06A 4kn2C-2iqfA:
undetectable		 4kn2C-2iqfA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 2iqf CATALASE
(Helicobacter
pylori) 		4 / 6 GLY A 128
ASP A 125
PRO A 317
ARG A 335
 HEM  A 550 (-3.9A)
None
None
HEM  A 550 (-3.5A)
 1.07A 4lajA-2iqfA:
undetectable
4lajB-2iqfA:
undetectable		 4lajA-2iqfA:
19.81
4lajB-2iqfA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 2iqf CATALASE
(Helicobacter
pylori) 		4 / 6 GLY A 197
ASP A 125
PRO A 317
ARG A 335
 None
None
None
HEM  A 550 (-3.5A)
 0.93A 4lajA-2iqfA:
undetectable
4lajB-2iqfA:
undetectable		 4lajA-2iqfA:
19.81
4lajB-2iqfA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2iqf CATALASE
(Helicobacter
pylori) 		5 / 12 ILE A  80
LEU A 126
SER A 261
ILE A 262
LEU A 203
 None
None
MHO  A 292 ( 3.9A)
MHO  A 292 ( 4.5A)
None
 1.08A 4qi9A-2iqfA:
undetectable		 4qi9A-2iqfA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2iqf CATALASE
(Helicobacter
pylori) 		5 / 11 ILE A  80
LEU A 126
SER A 261
ILE A 262
LEU A 203
 None
None
MHO  A 292 ( 3.9A)
MHO  A 292 ( 4.5A)
None
 1.02A 4qleB-2iqfA:
undetectable		 4qleB-2iqfA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 2iqf CATALASE
(Helicobacter
pylori) 		4 / 7 MET A 193
HIS A  56
GLY A 128
ASN A 129
 None
HEM  A 550 ( 3.4A)
HEM  A 550 (-3.9A)
HEM  A 550 (-3.2A)
 1.39A 5a5zC-2iqfA:
undetectable		 5a5zC-2iqfA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2iqf CATALASE
(Helicobacter
pylori) 		5 / 12 ILE A  80
LEU A 126
SER A 261
ILE A 262
LEU A 203
 None
None
MHO  A 292 ( 3.9A)
MHO  A 292 ( 4.5A)
None
 1.08A 5hi6A-2iqfA:
undetectable		 5hi6A-2iqfA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2iqf CATALASE
(Helicobacter
pylori) 		4 / 8 TYR A 339
ASP A 329
VAL A 127
GLY A 128
 HEM  A 550 (-3.8A)
None
HEM  A 550 (-4.8A)
HEM  A 550 (-3.9A)
 0.97A 5nzyA-2iqfA:
undetectable		 5nzyA-2iqfA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2iqf CATALASE
(Helicobacter
pylori) 		3 / 3 GLN A 464
TRP A 164
VAL A 455
 None
 0.99A 6auuA-2iqfA:
undetectable		 6auuA-2iqfA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2iqf CATALASE
(Helicobacter
pylori) 		4 / 7 GLN A 263
VAL A 264
ILE A  72
THR A  76
 None
MHO  A 292 ( 4.8A)
None
None
 0.90A 6cduF-2iqfA:
undetectable
6cduG-2iqfA:
undetectable		 6cduF-2iqfA:
20.32
6cduG-2iqfA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2iqf CATALASE
(Helicobacter
pylori) 		3 / 3 GLN A 353
TYR A 376
ASN A 374
 MHO  A 372 ( 4.7A)
None
None
 1.05A 6dwdC-2iqfA:
undetectable		 6dwdC-2iqfA:
23.42